Shift to a Younger Age and Regional Differences in Inflammatory Bowel Disease in Korea: Using Healthcare Administrative Data

Kim, Seo-Hee; Park, Yujin; Kim, Seong Pyo; Lee, Sung Hee; Oh, Seak Hee; Yang, Suk‐Kyun; Yoon, Hyung‐Jin; Kim, Kyung-Mo

doi:10.1007/s10620-021-07328-0

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…It was reported 26 that in the past 12 years, the peak age of UC diagnosis changed from 55 to 59 years old to 20–24 years old, while the peak age of CD changed from 19 years old to 17 years old, and males accounted for the majority of both CD and UC, which was consistent with this study and both showed a gradual younger incidence. A descriptive study 27 showed that the most common gastrointestinal symptoms in adult IBD patients were abdominal pain (63.9%) and diarrhea (62.3%), which were basically consistent with this study (57.3% and 61.2%, respectively).…”

Section: Discussionsupporting

confidence: 91%

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Zhang,

Liu,

et al. 2024

UEG Journal

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AimsTo investigate the current situation of mental psychology and quality of life (QoL) in patients with inflammatory bowel disease (IBD) in China, and analyze the influencing factors.MethodsA unified questionnaire was developed to collect clinical data on IBD patients from 42 hospitals in 22 provinces from September 2021 to May 2022. Multivariate Logistic regression analysis was conducted, and independent influencing factors were screened out to construct nomogram. The consistency index (C‐index), receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), calibration curve, and decision curve analysis (DCA) were used to evaluate the discrimination, accuracy, and clinical utility of the nomogram model.ResultsA total of 2478 IBD patients were surveyed, including 1371 patients with ulcerative colitis (UC) and 1107 patients with Crohn's disease (CD). Among them, 25.5%, 29.7%, 60.2%, and 37.7% of IBD patients had anxiety, depression, sleep disturbance and poor QoL, respectively. The proportion of anxiety, depression, and poor QoL in UC patients was significantly higher than that in CD patients (all p < 0.05), but there was no difference in sleep disturbance between them (p = 0.737). Female, higher disease activity and the first visit were independent risk factors for anxiety, depression and sleep disturbance in IBD patients (all p < 0.05). The first visit, higher disease activity, abdominal pain and diarrhea symptoms, anxiety, depression and sleep disturbance were independent risk factors for the poor QoL of patients (all p < 0.05). The AUC value of the nomogram prediction model for predicting poor QoL was 0.773 (95% CI: 0.754–0.792). The calibration diagram of the model showed that the calibration curve fit well with the ideal curve, and DCA showed that the nomogram model could bring clinical benefits.ConclusionIBD patients have higher anxiety, depression, and sleep disturbance, which affect their QoL. The nomogram prediction model we constructed has high accuracy and performance when predicting QoL.

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Section: Discussionsupporting

confidence: 91%

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Zhang,

Liu,

et al. 2024

UEG Journal

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“…Compared to the CD group (15.36%), the UC group had a higher percentage of elderly patients (39.53%). This is mainly because of the more apparent bimodal age distribution of UC and the fact that the age at diagnosis is 5–10 years earlier for CD than that of UC, as confirmed by prior research in Asia and the West ( 25 , 26 ). There are substantially more male patients in the younger group of CD patients (73.85%) than in the older group (59.41%).…”

Section: Discussionmentioning

confidence: 54%

“…Male predominance is a characteristic trait of Asian CD patients ( 27 ). In Asia-Pacific regions, males have a higher risk of CD from 15 to 50 years old ( 25 ). However, Sheila ( 28 ) reported that, in Western countries, females had a greater incidence of CD after puberty.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for poor sleep quality in patients with inflammatory bowel disease in China: A multicenter study

et al. 2023

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ObjectivesThis study aimed to determine the prevalence and risk factors for poor sleep quality in inflammatory bowel disease (IBD) patients.Methods2,478 IBD patients were enrolled to investigate their sleep quality using the Pittsburgh sleep quality index (PSQI). Clinical and psychological characteristics were collected to explore the risk factors for poor sleep quality. A hurdle model was conducted to predict poor sleep quality based on the risk factors. Among this hurdle model, the logistic regression model was used to determine risk factors of the presence of poor sleep quality, and the zero-inflated negative binomial model was employed to identify risk factors of the severity of poor sleep quality.ResultsIn this study, 1,491 (60.17%) IBD patients had poor sleep quality, and the proportion in the older group was higher than younger group (64.89% vs. 58.27%, p = 0.003). According to multivariable logistic regression, age (OR, 1.011; 95% CI [1.002,1.020]; p = 0.014), Patient Health Questionnaire-9 (PHQ-9) score (OR, 1.263; 95% CI [1.228,1.300]; p < 0.001), systemic (OR, 0.906; 95% CI [0.867,0.946]; p < 0.001) and emotional performance (OR, 1.023; 95% CI [1.005,1.043]; p = 0.015) were risk factors of the presence of poor sleep quality. The area under the curve (AUC) of the prediction model was 0.808. According to zero-truncated negative binomial regression, age (RR, 1.004; 95% CI [1.002,1.005]; p < 0.001) and PHQ-9 score (RR, 1.027; 95% CI [1.021,1.032]; p < 0.001) were risk factors of the severity of poor sleep quality.ConclusionThe prevalence of poor sleep quality among the older group in IBD patients was relatively high. Old age and depressive mood are risk factors for both the presence and severity of poor sleep quality.

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“…The average annual incidence rates of IBD in this study from 2010 to 2018 were 3.1 per 10 5 for CD and 6.7 per 10 5 for UC, comparable to the findings of previous studies conducted in Korea using the nationwide HIRA database. In such studies, the incidence of CD and UC ranged from 2.6 to 3.2 per 10 5 people and from 4.3 to 5.3 per 10 5 people, respectively, during 2005-2016[ 3 , 5 , 6 , 8 ]. The incidence of IBD in the present study was lower than that in North America (Olmsted County, Minnesota; the incidence of CD was 10.7 per 10 5 people and that of UC was 12.2 per 10 5 people) and Europe (Denmark; incidence of CD was 9.1 per 10 5 people and that of UC was 18.6 per 10 5 people)[ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018

Kim,

Lee,

Lee

et al. 2024

World J Gastroenterol

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BACKGROUND Inflammatory bowel disease (IBD) was previously regarded as a Western disease; however, its incidence is increasing in the East. The epidemiology of IBD in Asia differs significantly from the patterns in the West. AIM To comprehensively investigate the epidemiology of IBD in South Korea, including its incidence, prevalence, medication trends, and outcomes. METHODS We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases (RIDs), operated by the National Health Insurance Service of South Korea. Patients with IBD were identified based on the International Classification of Diseases, Tenth Revision, and RID diagnostic codes for Crohn’s disease (CD) and ulcerative colitis (UC) from 2010 to 2018. RESULTS In total, 14498 and 31409 patients were newly diagnosed with CD and UC, respectively, between 2010 and 2018. The annual average incidence of CD was 3.11 cases per 105 person-years, and that of UC was 6.74 cases per 105 person-years. Since 2014, the incidence rate of CD has been stable, while that of UC has steadily increased, shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in 2018. The CD and UC prevalence increased consistently over the study period; the use of 5-aminosalicylates and corticosteroids gradually decreased, while that of immunomodulators and biologics steadily increased in both CD and UC. The clinical outcomes of IBD, such as hospitalization and surgery, decreased during the study period. CONCLUSION The CD incidence has been stable since 2014, but that of UC has increased with a shift to a younger age at peak incidence between 2010 and 2018. IBD clinical outcomes improved over time, with increased use of immunomodulators and biologics.

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Shift to a Younger Age and Regional Differences in Inflammatory Bowel Disease in Korea: Using Healthcare Administrative Data

Cited by 12 publications

References 31 publications

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: A multicenter study

Risk factors for poor sleep quality in patients with inflammatory bowel disease in China: A multicenter study

Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018

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