Shift work and chronic disease: the epidemiological evidence

Abstract

Background Shift work, including night work, has been hypothesized to increase the risk of chronic diseases, including cancer, cardiovascular disease (CVD), metabolic syndrome and diabetes. Recent reviews of evidence relating to these hypotheses have focussed on specific diseases or potential mechanisms, but no general summary of the current data on shift work and chronic disease has been published.Methods Systematic and critical reviews and recent original studies indexed in PubMed prior to 31 December 2009 were retrieved, aided by manual searches of reference lists. The main conclusions from reviews and principle results from recent studies are presented in text and tables.Results Published evidence is suggestive but not conclusive for an adverse association between night work and breast cancer but limited and inconsistent for cancers at other sites and all cancers combined. Findings on shift work, in relation to risks of CVD, metabolic syndrome and diabetes are also suggestive but not conclusive for an adverse relationship.Conclusions Heterogeneity of study exposures and outcomes and emphasis on positive but non-significant results make it difficult to draw general conclusions. Further data are needed for additional disease endpoints and study populations.

Factors associated with Regular Dental Attendance among White-collar Workers

“…Although there have been few studies on a relationship between shift work and dental diseases, a relationship between shift work and systemic diseases such as cancer, cardiovascular disease and gastrointestinal disease have been discussed [22,23]. Knutsson reported that the possibility of affecting shift work on behavioural changes and stress because of shift work could cause disturbed sociotemporal patterns [24].…”

Horloges circadiennes et métabolisme : intégration des signaux métaboliques et environnementaux

“…Plusieurs études ont identifié une association des polymorphismes dans les gènes de l'horloge (Clock, Bmal1, Cry, Rev-erba) à l'obésité, l'hyperglycémie et le diabète de type 2 [19][20][21][22]. Par ailleurs, plusieurs études attestent de l'augmentation de la survenue de l'obésité et d'un diabète de type 2 chez les travailleurs postés [23]. L'impact des désyn-chronisations plus légères, mais répétées, telles que le décalage social entre les horaires de semaine et ceux du week-end, ou le déficit chronique de sommeil n'a SYNTHÈSE REVUES leur activité, oscille de façon circadienne.…”

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“…Shift work is associated with many negative health effects, such as obesity. On the other hand, different and long shift work can endanger the physical and mental health of military personnel (1). Shift work can have various adverse effects on human productivity and quality of work life, thus affecting the physical and * mental health, social security, and family life of individuals (2,3).…”