There was an error published in Development 139, 3849-3858.
Fig. 4B incorrectly showed an image of an apGal4>UAS-hWIF1 wing disc instead of an apGal4>NTDm -WD Hs -EGF Dm wing disc. The correct figure is shown below.As both genotypes display a very similar disc phenotype, this error does not change the conclusions of the paper.The authors apologise to readers for this mistake.
CORRIGENDUMThe WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog David Sánchez-Hernández, Javier Sierra, João Ramalho Ortigão-Farias and Isabel Guerrero RESEARCH ARTICLE 3849 Development 139, 3849-3858 (2012)
INTRODUCTIONSecreted signaling proteins of the Wnt and Hedgehog (Hh) families have important and conserved roles in metazoan development. These molecules also function postembryonically in homeostatic processes, such as stem cell maintenance. Alterations in these pathways during development cause a variety of congenital disorders and their aberrant activation has been implicated in proliferative disorders leading to many types of human cancer (Logan and Nusse, 2004;Moon et al., 2004). Hh and Wnt signals have been identified as morphogens in various systems. Morphogens are produced from a localized source and spread in the epithelium to form concentration gradients that organize patterning and control growth during development (Tabata and Takei, 2004). The mechanisms of morphogen distribution and the interpretation of morphogen gradients are of fundamental interest.During evolution, organisms have developed many ways to finetune Wnt and Hh signaling. One way of controlling this process is through extracellular modulators that directly interact with Wnt or Hh. It is important to consider how these modulators contribute to the robustness of the gradients and the ability of the cells to measure different morphogen levels. Recently, increasing numbers of cell surface and extracellular modulators have been shown to bind morphogens and to regulate their distribution and signaling. In vertebrates, there are several extracellular modulators of Wnt, including the secreted Frizzled-related protein (SFRP) family (Uren et al., 2000), Cerberus (Willert et al., 2003) and the Wnt inhibitory factor 1 (Wif-1) family (Hsieh et al., 1999).Wif-1 has been described as a secreted antagonist of Wnt signaling (Hsieh et al., 1999;Hunter et al., 2004;Surmann-Schmitt et al., 2009). Hsieh and colleagues have proposed that Wif-1 might sequester Wnt ligands, preventing binding to the receptor Frizzled (Frl) (Hsieh et al., 1999). During development, Wif-1 expression is detectable at early and late stages (Hsieh et al., 1999;Hunter et al., 2004;Surmann-Schmitt et al., 2009). Wif-1 is also expressed in adults in the nervous system, lungs, heart, and cartilage-mesenchyme interfaces of various organisms (Hsieh et al., 1999;Surmann-Schmitt et al., 2009). A relationship between Wif-1 and cancer has also been reported. Thus, human Wif-1 (WIF1) is downregulated in cancers (Mazieres et al., 2004;Kansara et al., 2009) and...