Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

Rousset, F; Robert, Jacques; Andary, M; Bonnin, J P; Souillet, G; Chrétien, Isabelle; Brière, Francine; Pène, Jérôme; Vries, J E de

doi:10.1016/0091-6749(91)90213-8

Cited by 215 publications

(163 citation statements)

References 36 publications

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“…IL-2 production has also been reported to be low in atopic patients after either anti-CD2 or anti-CD3 stimulation, but could be restored by anti-CD28 [32]. In 20 patients with elevated serum IgE levels, lowered IFN--y and enhanced IL-4 production but normal IL-2 production were found after stimulation of PBMC with phytohaemagglutinin (PHA) or Ca'' -ionophore with PMA [33]. The differences between the reported cytokine profiles and our results on cytokine production by atopic patients could be due lo the mode of stimulation, the patient selection or the cell types used.…”

Section: Discussionmentioning

confidence: 99%

IgE production in atopic patients is not related to IL-4 production

Kraan¹,

Aalberse²,

Aarden³

1994

Clinical and Experimental Immunology

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SUMMARYTo analy.se whether there is a general defect in T or B cell function in atopic individuals we have measured cytokine and IgE production by peripheral blood lymphocytes, isolated from 19 atopic donors (17 asthma/rhinitis and two dermatitis patients) in comparison with 19 non-atopic controls. After stimulation oflymphocytes with aiiti-CD2 and anti-CD28. we found no significant difference in IL-2, IL-4 and interferon-gamma (IEN--)) production. To examine the correlation between the production of IgE and IL-4, we stimulated lymphocytes with anti-CD2 and rIL-2. Under this condition both T eell iL-4 and B cell IgE production ean be measured. No significant diflerence was found for the amount of IgE and IL-4 produced between the two groups ( P > 005). The non-atopie donors showed a good correlation between IL-4 and IgE production (r = 0'70). Surprisingly, within the atopic group there was no correlation between IgE and IL-4 production at all (r = -0-04). The ratio of IgE to IL-4 was higher (although not signifieatitly) in the atopic group. Our data suggest that in atopic donors IgE production is less dependent on IL-4, and that other cytokines are involved.

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Section: Discussionmentioning

confidence: 99%

IgE production in atopic patients is not related to IL-4 production

Kraan¹,

Aalberse²,

Aarden³

1994

Clinical and Experimental Immunology

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“…Thus, class-specific regulation of lg production, the inhibition of lgE production and the stimulation of lgA production may alleviate allergic reactions. Such class-specific regulation of lg production is induced by lymphokines, such as IL-4, IL-5, IFN-c!, and IFN-y (Pene et al, 1988;Gauchat et al, 1991;Ochel et al, 1991;Rousset et al, 1991;Elson & Beagley, 1994). In addition, several biomaterials, such as bile acids, Iectins, and unsaturated fatty acids, exert a class-specific regulation of lg production of rat mesenteric lymph node (MLN) Iymphocytes (Yamada et al, 1993Lim et al, 1994a, b).…”

mentioning

confidence: 99%

Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

Yamada

Watanabe

Kaku

et al. 1997

FSTI

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We examined the effect of tea extracts on immunoglobulin (Ig) production of mesenteric lymph node lymphocytes of Sprague-Dawley rats and found that various extracts suppressed the production of lgA, IgG, and lgM. In addition, the original extracts of green and black teas strongly enhanced lgE production, and their 10' or 103 times diluted samples exerted an inhibitory effect. Similarly, tea polyphenols having a triphenol group enhanced lgE production at I mM and inhibited it at concentrations below 100 pM. On the contrary, diphenolic epicatechin did not affect lgE production. Though all tea polyphenols exerted inhibitory effect on the production of lgA and lgG at concentrations above 10 pM, triphenolic compounds, such as epigallocatechin gallate, gallic acid and pyrogallol, exerted an enhancing tendency on lgA production at 0.1 pM. These results suggest that the lg production-regulating activity of tea extract is partly due to tea polyphenols, especially those having a triphenol group.

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“…An abnor mal cytokine profile with enhanced IL-4 and reduced IFN-7 production has been described in the HyperIgE ('Job's') syndrome [9]. However, the absence in our patient of the typical physiognomy, the lack of serious infections with Staphylococcus aureus and the profound disturbance of cellular immunity, as well as the extreme eosinophilia, render this diagnosis very unlikely.…”

Section: Discussionmentioning

confidence: 52%

An unusual case of severe combined immunodeficiency with hypereosinophilia

Dams

Mascart‐Lemone

Schandené

et al. 1997

Journal of Internal Medicine

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Abstract. Dams ETHM, Mascart-Lemone F, Schandené L, van der Meer JWM (University Hospital Nijmegen, Nijmegen, The Netherlands, and Hôpital Erasme, Brussels, Belgium). An unusual case of severe com bined immunodeficiency with hypereosinophilia (Case Report). J Intern Med 1997; 242: 2 6 7 -9 .Investigation of the cytokine profile in a 26-year-old m an, suffering from combined immunodeficiency with hypereosinophilia, revealed high levels of interleukin-4 and interleukin-5 and relatively low levels of interleukin-2 and interferon gam m a, consistent with a T-helper type 2 pattern, as has been reported in O m enn's syndrome. However, some distinct clinical and immunological features suggest that this case may represent a unique disease with specific patho genesis.

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Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

Cited by 215 publications

References 36 publications

IgE production in atopic patients is not related to IL-4 production

IgE production in atopic patients is not related to IL-4 production

Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

An unusual case of severe combined immunodeficiency with hypereosinophilia

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