In this paper, an independent component analysis (ICA)-based disturbance separation scheme is proposed for statistical process monitoring. ICA is a novel statistical signal processing technique and has been widely applied in medical signal processing, audio signal processing, feature extraction and face recognition. However, there are still few applications of using ICA in process monitoring. In the proposed scheme, ICA is first applied to in-control training process data to determine the de-mixing matrix and the corresponding independent components (ICs). The IC representing the white noise information of the training data is then identified and the associated row vector of the IC in the de-mixing matrix is preserved. The preserved row vector is then used to generate the monitoring IC of the process data under monitoring. The disturbances in the monitoring process can be effectively enhanced in the monitoring IC. Finally, the traditional exponentially weighted moving average control chart is used to the monitoring IC for process control. For evaluating the effectiveness of the proposed scheme, simulated manufacturing process datasets with step-change disturbance are evaluated. Experiments reveal that the proposed monitoring scheme outperforms the traditional control charts in most instances and thus is effective for statistical process monitoring.