2001
DOI: 10.1128/iai.69.10.6148-6155.2001
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Shiga Toxin Translocation across Intestinal Epithelial Cells Is Enhanced by Neutrophil Transmigration

Abstract: Shiga toxin-producing E. coli (STEC) is a food-borne pathogen that causes serious illness, including hemolytic-uremic syndrome (HUS). STEC colonizes the lower intestine and produces Shiga toxins (Stxs

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Cited by 149 publications
(137 citation statements)
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“…To our knowledge this is the first study to report no effect of either acute acid stress or acid-adapted acid stress on Stx production. Since Stx is likely transcytosed across the intestinal epithelium at the site of bacterial attachment in the large intestine (Hurley et al, 2001), it is possible that Stx production may be more responsive to cues from the microenvironment of the large intestine rather than the acid stress of gastric passage.…”
Section: Discussionmentioning
confidence: 99%
“…To our knowledge this is the first study to report no effect of either acute acid stress or acid-adapted acid stress on Stx production. Since Stx is likely transcytosed across the intestinal epithelium at the site of bacterial attachment in the large intestine (Hurley et al, 2001), it is possible that Stx production may be more responsive to cues from the microenvironment of the large intestine rather than the acid stress of gastric passage.…”
Section: Discussionmentioning
confidence: 99%
“…Taking together all of the above data, we hypothesize that although IL-8 is produced in response to bacterial infection, IL-8 is not responsible for the specific step of transepithelial migration of PMNs to the airway lumen. Rather IL-8 is more likely required for the recruitment of PMNs from the blood stream through the interstitial space (5,8,20,22). Hence, PMN transepithelial migration must involve a distinct PMN chemoattractant.…”
Section: Map/erk Inhibitors Do Not Block Bacterial-induced Pmn Transmmentioning
confidence: 99%
“…After 1 h, all monolayers were washed and flipped back over into 24-well plates and 100 l of HBSS was added to the top (basolateral) chamber and 600 l of HBSS was added to the bottom (apical) chamber. After 2 h, supernatants in the apical and basolateral chambers were collected and filtered (0.2 M) before performing the IL-8 ELISA (Pierce/ Endogen, Rockford, IL) (22).…”
Section: Il-8 Assaymentioning
confidence: 99%
“…STEC was detected in the lung or thoracic cavity of piglets with a high-dose infection by the bacteriological method. This is distinct from human STEC, which is generally believed to be a noninvasive bacterium [10]. Therefore, the etiology of STEC diseases of human [9,10] and porcine [2,12,17] origins might be different.…”
mentioning
confidence: 99%