1990
DOI: 10.1677/joe.0.1240247
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Short- and long-term effects of an LHRH antagonist given during the prepubertal period on follicle dynamics in the rat

Abstract: The effects of the suppression of the high gonadotrophin concentrations normally present by the end of the second week of life on ovarian follicle dynamics were studied in immature rats. Gonadotrophins were suppressed by treatment with an LHRH antagonist (LHRH-A; Org. 30276) on days 6, 9, 12 and 15, and the total population of ovarian follicles was studied at 15 and 28 days, on the day of first oestrus and on the day of oestrus at or following 90 and 300 days of age. Primordial follicles were counted and growi… Show more

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Cited by 17 publications
(13 citation statements)
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“…Furthermore, GnRH antagonist treatment from Day 11 to Day 19 of life decreases ovarian weight by 35%, with apparent increases in follicular atresia and decreases in follicle growth. These findings demonstrate the critical role of endogenous gonadotropins in ovarian development and are consistent with earlier studies showing that prolonged GnRH antagonist treatment decreases ovarian weight, as well as the number of antral follicles, in infantile and juvenile rats [8]. The inhibitory action of GnRH antagonist on ovarian weight is likely a central pituitary effect and not a peripheral ovarian action as demonstrated by our observations that both hypophysectomy and GnRH antagonist treatment attenuate ovarian development.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Furthermore, GnRH antagonist treatment from Day 11 to Day 19 of life decreases ovarian weight by 35%, with apparent increases in follicular atresia and decreases in follicle growth. These findings demonstrate the critical role of endogenous gonadotropins in ovarian development and are consistent with earlier studies showing that prolonged GnRH antagonist treatment decreases ovarian weight, as well as the number of antral follicles, in infantile and juvenile rats [8]. The inhibitory action of GnRH antagonist on ovarian weight is likely a central pituitary effect and not a peripheral ovarian action as demonstrated by our observations that both hypophysectomy and GnRH antagonist treatment attenuate ovarian development.…”
Section: Discussionsupporting
confidence: 93%
“…Treatment with dihydrotestosterone propionate during the first week of life decreased serum gonadotropins and led to a delay in ovarian FSH receptor acquisition [6]. Furthermore, treatment of infantile rats with eCG increased ovarian weight [7], whereas treatment of neonatal rats with a GnRH antagonist reduced the number of growing ovarian follicles found at puberty [8]. Although several in vitro studies have suggested an important role of FSH in preantral follicle growth [9][10][11][12], other studies indicated that treatment with FSH does not enhance preantral follicle growth [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…In contrast to the normal primordial numbers found in hpg ovaries, hypophysectomized (Meredith et al 1986) or GnRH-antagonist treated (Meijs-Roelofs et al 1990) rats exhibit a decreased rate of loss of primordial follicles, resulting in higher than normal primordial follicle numbers. The different primordial numbers found in these gonadotrophin-deficient mouse and rat models remains an enigma.…”
Section: Discussionmentioning
confidence: 77%
“…The term recruitment has been used frequently by different investigators to describe two important but distinct decision points during follicle development (7)(8)(9)(10). The dormant primordial follicles are recruited into the growing follicle pool in a continuous manner, whereas increases in circulating FSH during each reproductive cycle recruit a cohort of antral follicles.…”
Section: B Initial Vs Cyclic Recruitmentmentioning
confidence: 99%
“…Treatment with dihydrotestosterone propionate during the first week of life decreases serum gonadotropins and leads to a delay in ovarian FSH receptor acquisition (131). Conversely, treatment of infantile rats with PMSG increases ovarian weight (132), whereas treatment of neonatal rats with a GnRH antagonist reduces the number of growing ovarian follicles found at puberty (7).…”
Section: Preantral Follicles Are Gonadotropin Responsivementioning
confidence: 99%