Short- and long-term outcomes of pneumonectomy in a tertiary center

Qadri, S.; Chaudhry, Mubarak; Cale, Alex; Cowen, Michael E.; Loubani, Mahmoud

doi:10.1177/0218492316629851

Cited by 8 publications

(11 citation statements)

References 13 publications

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“…Some studies have similar results. Qadri et al 19 reported median survival was better in left pneumonectomy (left 2.7 years vs. right 1.9 years), as well as an improved long-term survival (Log-rank P =0.006). Fernandez and associates 18 reviewed 9746 patients underwent pneumonectomy in the Surveillance, Epidemiology, and End Results (SEER) database, and found a right pneumonectomy is correlated with almost twice the perioperative mortality as a left pneumonectomy.…”

Section: Discussionmentioning

confidence: 97%

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Gu¹,

Wang²,

Pan³

et al. 2017

J. Cancer

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Introduction: To investigate postoperative complications and the prognostic risk factors of patients underwent pneumonectomy. Methods: Four hundred and six patients underwent pneumonectomy were subjected to the study. All the clinicopathologic data including age, gender, smoking history, surgical treatment, postoperative complications, tumor staging and the follow-up information were investigated. Results: The 30-day and 90-day mortality rates were 3.2% and 6.2%, respectively. Postoperative complications developed in 149 patients (36.7%), mainly included arrhythmia, transfusion, pulmonary infection, bronchopleural fistula and acute respiratory distress syndrome. During the follow-up, 189 patients experienced a relapse, consisting of 51 patients with local recurrence and 138 with distant recurrence. The median survival time was 24.4 months and the overall 1-year, 3-year and 5-year survival rates were 82.7%, 50.9% and 32.5%, respectively. Moreover, the overall 1-year, 3-year, 5-year survival rates for patients with non-small cell lung cancer (NSCLC) were 84.1%, 52.1% and 32.5%, respectively and patients with small cell lung cancer (SCLC) were 56.1%, 38.5% and 28.8%, respectively. Among NSCLCs, adenocarcinomas had a worse prognosis than squamous carcinomas. Compared to right pneumonectomy, patients with left pneumonectomy had a better prognosis. Multivariable analysis revealed ICU stay, disease stage, nodal stage and adjuvant chemotherapy were all significant predictors of overall survival (OS). Conclusions: Pneumonectomy is still a valuable and effective treatment option for patients with advanced lung cancer. Surgeons should be more cautious when patients had higher disease stage, adenocarcinoma and right-side lung cancer. Neoadjuvant chemotherapy did not affect the prognosis. Pneumonectomy could also achieve acceptable survival outcomes in well-selected SCLC patients.

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Section: Discussionmentioning

confidence: 97%

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Gu¹,

Wang²,

Pan³

et al. 2017

J. Cancer

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“…Pneumonectomy is a rare procedure in pulmonary surgery perioperative mortality to 3.3% (8). In our institute, 30-day mortality of 100 patients under pneumonectomy was 4.0%.…”

Section: Discussionmentioning

confidence: 76%

The analysis of prognosis factor in patients with non-small cell lung cancer receiving pneumonectomy

Wang¹,

Liu²,

Zhang³

et al. 2020

J Thorac Dis

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Background: Pneumonectomy is a procedure that possesses several side effects, but is sometimes necessary in the management of non-small cell lung cancer (NSCLC). The benefits of pneumonectomy have yet to be clearly outlined. Methods: Data of 100 cases were extracted from the medical records of patients that underwent a pneumonectomy for NSCLC from January 2007 to December 2016. Primary outcomes were 5-year overall survival (OS) and 30-day mortality. Statistical comparisons were performed using the Chi-Square test.Kaplan-Meier curves were utilized to evaluate the 5-year OS which were compared using the log-rank test.Multivariable analysis of survival data was done using risk proportional model. Results:The 5-year OS of NSCLC after pneumonectomy is 32.3%. Squamous cell carcinomas had a better prognosis than adenocarcinomas (P=0.039). Patients with higher N stage had a worse prognosis.Among patients undergoing pneumonectomy with N2 lymphatic metastasis, those who also underwent neoadjuvant therapy achieved a better 5-year OS (P=0.042). The 30-day mortality was 4.0%. Conclusions: Pneumonectomy sometimes is inevitable and necessary in certain subtypes of NSCLC with acceptable perioperative mortality and long-term survival. For patients with NSCLC undergoing pneumonectomy, pathological diagnosis and nodal stage were independent predictors of OS. When pneumonectomy was done in patients with NSCLC and N2 lymphatic metastasis, a better long-term OS could be achieved amongst patients receiving neoadjuvant therapy compared to those without neoadjuvant therapy.

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“…For patients undergoing pneumonectomy, some recent studies have indicated that it may overestimate mortality in high risk groups, whilst underestimating risk in low risk groups 55 . When applied to a large UK-based population it appeared to generally overestimate mortality 56,57 .…”

Section: Thoracoscorementioning

confidence: 94%

Assessment and Optimisation of Lung Cancer Patients for Treatment with Curative Intent

et al. 2016

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Over the past decade the field of lung cancer management has seen many developments. Coupled with an ageing population and increasing rates of comorbid illness, the work-up for treatments with curative intent has become more complex and detailed. As well as improvements in imaging and staging techniques, developments in both surgery and radiotherapy may now allow patients who would previously have been considered unfit or not appropriate for treatment with curative intent to undergo radical therapies. This overview will highlight published studies relating to investigation and staging techniques, together with assessments of fitness, with the aim of helping clinicians to determine the most appropriate treatments for each patient. We also highlight areas where further research may be required.

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Short- and long-term outcomes of pneumonectomy in a tertiary center

Cited by 8 publications

References 13 publications

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

Comprehensive study of prognostic risk factors of patients underwent pneumonectomy

The analysis of prognosis factor in patients with non-small cell lung cancer receiving pneumonectomy

Assessment and Optimisation of Lung Cancer Patients for Treatment with Curative Intent

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