Short- and medium-chain chlorinated paraffins in human blood serum of Czech population

Tomasko, Jakub; Stupák, Michal; Parizkova, Denisa; Polachova, Andrea; Šrám, Radìm J.; Topinka, Jan; Pulkrabová, Jana

doi:10.1016/j.scitotenv.2021.149126

Cited by 19 publications

(7 citation statements)

References 33 publications

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“…In terms of human monitoring efforts, existing studies report either metabolites of PAEs and non-PAE alternatives in urine [87][88][89][90] , or CPs in blood [91][92][93][94] and breast milk [95,96] . Unfortunately, to our knowledge, both groups of plasticizers have yet to be monitored together within the same set of subjects.…”

Section: Discussionmentioning

confidence: 99%

Ecological and health risks of polycyclic aromatic hydrocarbons in the sediment core of Phayao Lake, Thailand

Deelaman¹,

Choochuay²,

Pongpiachan³

et al. 2023

J Environ Expo Assess

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Polycyclic aromatic hydrocarbons (PAHs) in sediment cores from Phayao Lake were investigated in terms of their concentration, distribution, and potential effects on the environment and human health. The concentration of Σ16PAHs ranged from 77.6 to 1251.1 ng g-1. Additionally, low molecular weight PAHs (two or three fused aromatic rings) were dominant, indicating that the main source of PAHs is the incomplete combustion of organic sources. The toxic equivalent quantities (TEQs) of 16 PAHs varied from 2.67 to 155.09 ng g-1, with an average of 38.29 ± 46.69 ng g-1. Furthermore, the TEQs of 9 known carcinogenic PAHs averaged 20.77 ± 30.63 ng g-1. B[a]P had the highest TEQ, followed by D[a,h]A and B[k]F, with values of 16.93 ± 25.49, 13.89 ± 15.37 and 2.12 ± 3.64, respectively. The RQ(NCs) of ∑PAHs (RQ∑PAHs(NCs)) ranged from 1.65 × 10-4 to 6.27 × 10-1 with an average value of 1.18 × 100 ± 1.52 × 100. Moreover, RQ(NCs) was less than 1 for individual PAHs, indicating a minor risk. However, RQ(MPCs) was less than 1 for individual PAHs, indicating a moderate risk. The results showed a significant incremental lifetime cancer risk (ILCR) from sediment-bound PAHs with dermal absorption, followed by ingestion and inhalation, as the prevalent route of exposure. The measured ILCR values of all PAHs were less than 10-6 for both adults and children, which were lower than the baseline value, indicating that each PAH poses a low risk of cancer to humans. This study provides information for control and preventive actions to limit future PAH pollution in Phayao Lake.

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Section: Discussionmentioning

confidence: 99%

Ecological and health risks of polycyclic aromatic hydrocarbons in the sediment core of Phayao Lake, Thailand

Deelaman¹,

Choochuay²,

Pongpiachan³

et al. 2023

J Environ Expo Assess

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“…37 Although increased ∑SCCP and ∑MCCP levels were also reported in samples obtained in 2019 compared with samples from 2007 to 2009, the pooled serum concentrations of ∑CPs in Northern Norway (ranging from 0.03 to 0.26 μg L −1 ) on a wet weight basis, were three to four orders of magnitude lower than those in other reports, especially from China. 42,44 Moderate ∑SCCP and ∑MCCP contamination was reported in serum samples from Czech police officers (370 ng per g lw and 360 ng per g lw, respectively) 41 and Australian pooled male serum samples (97 ng per g lw and 190 ng per g lw, respectively) when calculated as the lipid-adjusted concentration. 43 The contamination levels are also varied within China.…”

Section: Biomonitoring Of Cps In Human Samplesmentioning

confidence: 99%

“…According to the length of the carbon chain in the SCCPs, a regional difference was observed. ΣC 10 was dominant in the Czech Republic, 41 Korea, Japan 51 and multiple cities/provinces in China, including Hangzhou, 48 Dalian, 40 Beijing, 37 Wuhan, 36 Mianyang, 50 and Henan. 59 ΣC 11 wwas found to be dominant in the serum samples collected in Northern Norway 42 and Australia, 43 while ΣC 13 accounted for more than 40% in Jinan; 44,46,47 and Shenzhen, 49 China.…”

Section: Biomonitoring Of Cps In Human Samplesmentioning

confidence: 99%

“…36 Liquid-liquid extraction was typically performed and followed with a cleanup procedure before instrument analysis using gas chromatography (GC) or high-performance liquid chromatography (HPLC). 35,41 CPs have been detected in serum in Northern Norway, 42 Australia, 43 Czech Republic 41 and China. 44 The detection of CPs in placenta, cord blood and breast milk indicated potential risk to the fetus and breast-feeding infants.…”

Section: Biomonitoring Of Cps In Human Samplesmentioning

confidence: 99%

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Biomonitoring, exposure routes and risk assessment of chlorinated paraffins in humans: a mini-review

Liao¹,

Xue²,

Zhou³

et al. 2023

Environ. Sci.: Processes Impacts

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“…SCCPs and MCCPs have been detected in human tissues including fingernails, hair, blood, cord serum, the placenta, and breast milk from different countries [55][56][57][58][59][60][61][62][63][64][65]79,80]. Human foodstuffs, including aquatic food, meat, baby food, noodles, green tea, cereals and beans, milk, rice seeds, and oil food, from China and Europe were also found to contain SCCPs and MCCPs [46,[66][67][68][69][70][71][72][73][74][75][76][77][78].…”

Section: Occurrence Of Cps In Organismsmentioning

confidence: 99%

Bioaccumulation and Biotransformation of Chlorinated Paraffins

Chen

Mai

Luo

2022

Toxics

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Chlorinated paraffins (CPs), a class of persistent, toxic, and bioaccumulated compounds, have received increasing attention for their environmental occurrence and ecological and human health risks worldwide in the past decades. Understanding the environmental behavior and fate of CPs faces a huge challenge owing to the extremely complex CP congeners. Consequently, the aims of the present study are to summarize and integrate the bioaccumulation and biotransformation of CPs, including the occurrence of CPs in biota, tissue distribution, biomagnification, and trophic transfer, and biotransformation of CPs in plants, invertebrates, and vertebrates in detail. Biota samples collected in China showed higher CP concentrations than other regions, which is consistent with their huge production and usage. The lipid content is the major factor that determines the physical burden of CPs in tissues or organs. Regarding the bioaccumulation of CPs and their influence factors, inconsistent results were obtained. Biotransformation is an important reason for this variable. Some CP congeners are readily biodegradable in plants, animals, and microorganisms. Hydroxylation, dechlorination, chlorine rearrangement, and carbon chain decomposition are potential biotransformation pathways for the CP congeners. Knowledge of the influence of chain length, chlorination degree, constitution, and stereochemistry on the tissue distribution, bioaccumulation, and biotransformation is still scarce.

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Short- and medium-chain chlorinated paraffins in human blood serum of Czech population

Cited by 19 publications

References 33 publications

Ecological and health risks of polycyclic aromatic hydrocarbons in the sediment core of Phayao Lake, Thailand

Ecological and health risks of polycyclic aromatic hydrocarbons in the sediment core of Phayao Lake, Thailand

Biomonitoring, exposure routes and risk assessment of chlorinated paraffins in humans: a mini-review

Bioaccumulation and Biotransformation of Chlorinated Paraffins

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