Short columns with molecularly imprinted monolithic stationary phases for rapid separation of diastereomers and enantiomers

Huang, Xiaodong; Qin, Feng; Chen, Xiaoming; Liu, Yueqi; Zou, Hanfa

doi:10.1016/j.jchromb.2004.01.015

Cited by 68 publications

(33 citation statements)

References 33 publications

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“…Separation of the corresponding enantiomers was achieved but the separation mechanism was not mentioned. In recent years, the uses of monolithic media for superior chromatographic separation in high-performance liquid chromatography and capillary electrochromatography have attracted considerable attention [94][95][96][97][98][99][100][101][102].…”

Section: Monolithic Imprinted Polymerizationmentioning

confidence: 99%

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Yan

Row

2006

IJMS

460

231

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Abstract:Molecularly imprinted polymers (MIP) exhibiting high selectivity and affinity to the predetermined molecule (template) are now seeing a fast growing research. However, optimization of the imprinted products is difficult due to the fact that there are many variables to consider, some or all of which can potentially impact upon the chemical, morphological and molecular recognition properties of the imprinted materials. This review present a summary of the principal synthetic considerations pertaining to good practice in the polymerization aspects of molecular imprinting, and is primarily aimed at researcher familiar with molecular imprinting methods but with little or no prior experience in polymer synthesis. The synthesis, characteristic, effect of molecular recognition and different preparation methods of MIP in recent few years are discussed in this review, unsolved problems and possible developments of MIP were also been briefly discussed.

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Section: Monolithic Imprinted Polymerizationmentioning

confidence: 99%

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Yan

Row

2006

IJMS

460

231

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“…The operating conditions in these columns were chosen to maximize the RDX removal in the shortest time possible and minimize the required chemicals. Short columns also offer lower flow resistance (pressure drop) as demonstrated by Huang et al (2004): the pressure drop for a short column (38 mm) was only 3.63 MPa at the flow rate of 7.0 mL min À1 , whereas it was 6.66 MPa for a long column (150 mm) at the flow rate of 2.5 mL min À1 . When nanoparticles are involved, they tend to often block the flow more as they aggregate due to their magnetic properties.…”

Section: Rdx Chemical Degradation In Soil Using Flow-through Column Ementioning

confidence: 98%

Dynamic and equilibrium studies of the RDX removal from soil using CMC-coated zerovalent iron nanoparticles

Naja

Apiratikul

Pavasant

et al. 2009

Environmental Pollution

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RDX chemical degradation in a contaminated soil was conducted using coated zerovalent iron nanoparticles in both batchRapid chemical degradation of toxic RDX explosive in soil can be accomplished using zerovalent nanoiron suspension stabilized in dilute carboxymethyl cellulose solution (CMC-ZVINs). The effect of operating conditions (redox-potential, Fe/RDX molar ratio) was studied on batchwise removal of RDX in contaminated soil. While anaerobic conditions resulted in 98% RDX removal in 3 h, only slightly over 60% RDX removal could be attained under aerobic conditions. The molar ratio did not have any influence on the intermediate and final RDX degradation products (methylenedinitramine, nitroso derivative, N 2 ,N 2 O, NO 2 À ), however, their distribution changed. Dynamic studies were conducted using a flow-through short column packed with RDX-contaminated soil and fed with CMC-ZVINs. The column was operated at two interstitial velocities (2.2 and 1.6 cm min À1 ), resulting in the 76.6% and 95% removal of the initial RDX soil contamination load (60 mg kg À1 ), respectively. While the column operating conditions could be further optimized, 95% of the RDX initially present in the contaminated soil packed in the column was degraded when flushed with a CMC-ZVINs suspension in this work.

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“…Enantiosseparações muito rá-pidas foram obtidas quando se utilizou eluição por gradiente a vazões elevadas. Huang et al 70 prepararam fases monolíticas com impressão molecular com cinchonina, N-(carbobenzilóxi)-Ltriptofano (Cbz-L-Trp) e Fmoc-L-triptofano (Fmoc-L-Trp) em colunas curtas para separações rápidas de enantiômeros e diastereoisômeros de alcalóides cinchonina. Todas as separações foram obtidas com boas estereosseletividades em menos de 3 min empregando vazões de até 9 mL min -1 .…”

Section: Aplicações Cromatografia Líquida De Alta Eficiênciaunclassified

Fases estacionárias monolíticas para separações cromatográficas

Faria¹,

Bottoli²,

Jardim³

2006

Quím. Nova

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Recebido em 28/2/05; aceito em 22/6/05; publicado na web em 8/12/05 MONOLITHIC STATIONARY PHASES FOR CHROMATOGRAPHIC SEPARATIONS. Monolithic stationary phases represent a new generation of chromatographic separation media. These phases consist of a continuous separation bed prepared by in situ polymerization or consolidation inside the column tubing. In recent years, their simple preparation procedure, unique properties and excellent performance have attracted quite remarkable attention in liquid chromatography and capillary electrochromatography. This review summarizes the preparation, characterization and applications of monolithic stationary phases. The analytical potential of these columns is demonstrated with separations involving various families of compounds in different separation modes.Keywords: monolithic stationary phases; high performance liquid chromatography; capillary electrochromatography. INTRODUÇÃOApesar de mais de trinta anos de intensa pesquisa e do alto padrão alcançado atualmente pela tecnologia de colunas para cromatografia líquida, alguns problemas persistem e novos desenvolvimentos impulsionam pesquisas nesta área. O bom desempenho cromatográfico das colunas atuais é resultado do desenvolvimento da tecnologia de colunas, que permitiu a produção de partí-culas bem definidas e cada vez menores, concomitante à diminuição do comprimento e do diâmetro da coluna. Porém, as colunas recheadas com materiais particulados parecem ter alcançado seu limite de desempenho nos equipamentos convencionais. Embora seja tecnicamente possível uma maior redução do tamanho das partículas (< 3,0 µm), na prática esta possibilidade se torna inviável. A diminuição da permeabilidade das colunas recheadas com partí-culas muito pequenas provoca um aumento acentuado da resistên-cia ao fluxo de fase móvel e, conseqüentemente, uma considerável queda de pressão ao longo da coluna, resultando em separações de baixa eficiência [1][2][3] . Portanto, novas estratégias vêm sendo delineadas para obtenção de colunas mais eficientes.MacNair et al. 4 propuseram um sistema de cromatografia lí-quida de ultra-alta pressão (ultra-CLAE) ("ultrahigh-pressure liquid chromatography"), que possibilita separações a pressões de até uma ordem de grandeza superior ao sistema convencional de cromatografia líquida. A utilização de eletrocromatografia capilar (ECC) ("capillary electrochromatography") também foi sugerida em substituição aos equipamentos convencionais, pois a vazão da fase móvel é controlada por um fluxo eletroosmótico (FEO) ("electroosmotic flow") -fluxo de uma solução aquosa em um tubo com paredes e partículas eletrocarregadas sob a ação de campo elétrico alto -o qual independe de pressão 5 . Eficiências de colunas superiores a duzentos mil pratos m -1 são obtidas por esta técnica 2 . Porém, a utilização de instrumentação comum de cromatografia líquida de alta eficiência (CLAE) ("high performance liquid chromatography"), obtendo eficiências de separação nestas proporções, também tornou-se possível com o desenvolvimento das colun...

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Short columns with molecularly imprinted monolithic stationary phases for rapid separation of diastereomers and enantiomers

Cited by 68 publications

References 33 publications

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Characteristic and Synthetic Approach of Molecularly Imprinted Polymer

Dynamic and equilibrium studies of the RDX removal from soil using CMC-coated zerovalent iron nanoparticles

Fases estacionárias monolíticas para separações cromatográficas

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