Short communication: Genetic analysis of dairy bull fertility from field data of Brown Swiss cattle

Tiezzi, Francesco; Maltecca, Christian; Penasa, M.; Cecchinato, Alessio; Bittante, Giovanni

doi:10.3168/jds.2013-6885

Cited by 10 publications

(13 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a mapping cohort of 3736 BSW bulls from which semen was collected at semen collection centers under standardized conditions, only 10 % of the phenotypic variation of bull fertility was explained by autosomal variants. This estimate suggests that the additive genetic heritability of bull fertility is low in BSW cattle, which agrees with findings in other cattle populations [19][20][21][22][23] . It is possible that we underestimated the genomic heritability of bull fertility, because the genomic relationship matrix was constructed from autosomal SNPs only.…”

Section: Discussionsupporting

confidence: 90%

Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population

Hiltpold

Kadri

Janett

et al. 2020

Preprint

View full text Add to dashboard Cite

Cattle are ideally suited to investigate the genetics of male fertility. Semen from individual bulls is used for thousands of artificial inseminations for which the fertilization success is monitored. In a cohort of 3881 bulls that had genotypes at 589,791 SNPs, we reveal four novel recessive QTL for male fertility using haplotype-based association testing. We detect either missense or nonsense variants in SPATA16, VWA3A, ENSBTAG00000006717 and ENSBTAG00000019919 that are in linkage disequilibrium with the QTL. A QTL for bull fertility on BTA1 is also associated with sperm head shape anomalies. Using whole-genome sequence and transcriptome data, we prioritise a missense variant (p.Ile193Met) in SPATA16 as candidate causal variant underlying this QTL. Our findings in a dairy cattle population provide evidence that recessive variants may contribute substantially to quantitative variation in male fertility in mammals.

show abstract

Section: Discussionsupporting

confidence: 90%

Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population

Hiltpold

Kadri

Janett

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…For FSC, the ratio of variance of service sire to total variance was 0.01 or lower for both heifers and cows (not shown). Very small variance of service sire was reported in an intensive system (Jamrozik et al, 2005;Kuhn and Hutchinson, 2008;Tiezzi et al, 2013). Repeatabilities of fertility traits for multiparous cows (not shown) ranged from 0.10 (DFLS) to 0.17 (DTFS).…”

Section: Short Communication: Genetic Analysis For Fertility Traits Omentioning

confidence: 86%

Short communication: Genetic analysis for fertility traits of heifers and cows from smallholder dairy farms in a tropical environment

Buaban¹,

Duangjinda

Suzuki

et al. 2015

Journal of Dairy Science

View full text Add to dashboard Cite

The objective of this study was to estimate genetic parameters for various fertility traits on Holstein upgraded dairy heifers and cows in a smallholder system under tropical conditions using data sets from the Thailand national recording scheme. The investigated traits were age at first service (AFS), age at first calving (AFC), days from calving to first service (DTFS), days between first and last service (DFLS), days open (DO), calving interval (CI), number of services per conception (NSPC), and conception at first service (FSC). The data consisted of 68,555, 34,401, and 54,004 records on heifers, primiparous, and multiparous cows, respectively, calving between 1996 and 2011. Gibbs sampling was employed to obtain (co)variance components using both univariate and bivariate analyses with linear and threshold animal models. Virgin heifers had better fertility performance than primiparous and multiparous cows. The reproductive performance in primiparous cows was inferior compared with multiparous cows. Cows with higher Holstein-Friesian blood showed lower reproductive efficiency. Estimated heritabilities for most of the fertility traits were 0.04 or less except for AFS (0.26) and AFC (0.25). The estimated genetic correlations among fertility traits within parity indicated that selection for cows with high conception rate could lead to shortened DO and CI, as well as DTFS. The FSC and NSPC could be used as the best indicators for heifer and cow fertility and could be complemented by other traits, which were genetically considered as different traits such as DTFS and DFLS in terms of a fertility index. This would enable efficient selection for better fertility. Genetic correlations for fertility traits in primiparous and multiparous cows were very high (>0.90), but those between heifers and cows were lower (0.03 to 0.83). The latter results indicated that fertility traits of heifers and cows should be considered as different traits.

show abstract

“…The fertility of AI bulls can be quantified using insemination success adjusted for environmental and genetic effects [4,6]. However, the heritability of bull fertility is low [6][7][8]. Semen traits that are routinely recorded at AI centers such as have higher heritability than bull fertility [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility

et al. 2020

View full text Add to dashboard Cite

Cattle are ideally suited to investigate the genetics of male reproduction, because semen quality and fertility are recorded for all ejaculates of artificial insemination bulls. We analysed 26,090 ejaculates of 794 Brown Swiss bulls to assess ejaculate volume, sperm concentration, sperm motility, sperm head and tail anomalies and insemination success. The heritability of the six semen traits was between 0 and 0.26. Genome-wide association testing on 607,511 SNPs revealed a QTL on bovine chromosome 6 that was associated with sperm motility (P = 2.5 x 10 −27), head (P = 2.0 x 10 −44) and tail anomalies (P = 7.2 x 10 −49) and insemination success (P = 9.9 x 10 −13). The QTL harbors a recessive allele that compromises semen quality and male fertility. We replicated the effect of the QTL on fertility (P = 7.1 x 10 −32) in an independent cohort of 2481 Brown Swiss bulls. The analysis of wholegenome sequencing data revealed that a synonymous variant (BTA6:58373887C>T, rs474302732) in WDR19 encoding WD repeat-containing protein 19 was in linkage disequilibrium with the fertility-associated haplotype. WD repeat-containing protein 19 is a constituent of the intraflagellar transport complex that is essential for the physiological function of motile cilia and flagella. Bioinformatic and transcription analyses revealed that the BTA6:58373887 T-allele activates a cryptic exonic splice site that eliminates three evolutionarily conserved amino acids from WDR19. Western blot analysis demonstrated that the BTA6:58373887 T-allele decreases protein expression. We make the remarkable observation that, in spite of negative effects on semen quality and bull fertility, the BTA6:58373887 T-allele has a frequency of 24% in the Brown Swiss population. Our findings are the first to uncover a variant that is associated with quantitative variation in semen quality and male fertility in cattle.

show abstract

Short communication: Genetic analysis of dairy bull fertility from field data of Brown Swiss cattle

Cited by 10 publications

References 16 publications

Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population

Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population

Short communication: Genetic analysis for fertility traits of heifers and cows from smallholder dairy farms in a tropical environment

Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility

Contact Info

Product

Resources

About