Short Contact 70% Glycolic Acid Peels as a Treatment for Photodamaged Skin A Pilot Study

Piacquadio, Daniel; Dobry, Mary M.; Hunt, Steven R.; Andree, Christoph; Grove, Gary L.; Hollenbach, Kathryn A.

doi:10.1111/j.1524-4725.1996.tb00346.x

Cited by 25 publications

(17 citation statements)

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“…The present report provides evidence that glycolic acid, a peeling agent also shown of some utilky in counteracting the effects of photoaging (13,15,17,25,26) acts synergistically with the antioxidant activity of vitamin E and melatonin m vitro, the effect evaluated with vitamin E being greater than that with melatonin.…”

Section: Discussionmentioning

confidence: 49%

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Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

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Summary. Considerable interest has been raised concerning the use of natural compounds in preventing skin aging and photoaging In the idea that the combined action of agents increasing epiderlnal turnover with antioxidants could be ach,antageous in cosmetic and therapeuthic treatments, we first investigated if ~z-glycolic acid affected or prevented the antioxidant activity of vitanffn E and of melatonin, two compounds found beneficial as topical photoprotectant. Assays were carried out m vitro either in a biomimetic liposomal system, or in human skin homogenates. Lipid peroxidation was monitored spectrophotometrically by the time course of lipid hydroperoxide production in liposomes and by formation of TBA reactive substances (TBARS) in skin homogenates. Glycolic acid. at 25 ~tM to 1 raM, showed a mild, concentration-dependent antioxidant effect in liposomes, as evalnated by a slight decrease of the peroxidation rate, while, at I mM, reduced TBARS production in skin homogenates by 14 %. Combinations of either vitamin E or melatonin with giycolic acid, in a 1:5 to 1:200 molar ratio, resulted in a clear synergistic protection of liposomes, more evident for the combination of glycolic acid with vitamin E An amount of ~'nergism up to 250% and up to 80% was evahmted with vitamin E and melatonin, respectively. Consumption rate ofvitanffn E during peroxidation of liposomes, in the absence or in the presence of glycolic acid, suggests that regeneration of vitamin E 1nay in part explain the observed synergism. Synergistic antioxidant activity between vitamin E and giycolic acid was also observed in skin homogenates, whereas the effect of glycolic acid on the antioxidunt activity of melatonin appeared additive. However, the combination of these three compounds inhibited TBARS production almost completely.Our data provide evidence that glycolic acid can strongly potentiate the antioxidant action of melatonin and vitamin E. Tiffs may suggest the advantage of combining ~-glycolic acid with these antioxidants in skin designed preparations, both to improve penetration and availability of antioxidants to epidermal layers and to enhance their protective potential.

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Section: Discussionmentioning

confidence: 49%

“…some inconsistency in the reports about effects of glycolic acid on photodamage in humans (13,15,17,25,26). Interactions of glycolic acid with endogenous vitanfin E in different subjects, could affect the individual responses to gtycolic acid treatments and may help to explain these discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

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“…Type III photodamage combines types I and II as well as precancerous actinic keratoses and non-melanoma skin (Table I). IPL, as well as many other treatments, such as topical glycolic acids, retinoids, anti-oxidants, dermabrasion, microdermabrasion, and laser skin resurfacing have been shown to improve photodamage (9)(10)(11)(12)(13)(14). All of these modalities address types I and II photodamage, However, there is now early anecdotal evidence that IPL plus ALA photodynamic photorejuvenation may address all three types of photodamage (1).…”

Section: Introductionmentioning

confidence: 98%

Ultrastructural changes seen after ALA‐IPL photorejuvenation: A pilot study

Marmur

Phelps

Goldberg

2005

Journal of Cosmetic and Laser Therapy

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“…28 Glycolic acid (HOCH 2 COOH), the monomer of PGA, is known to dermatologists as an alpha-hydroxy acid that improves conditions such as photoaging, wrinkling, dry skin, acne, and other skin conditions. 29,30 A naturally occurring compound found in sugar cane, 31 its simple chemical structure gives it the potential to interact in various pathways of cell metabolism. 32 In fibroblasts, for example, GA has been found to increase synthesis of glycosaminoglycans and collagen, 29 but decreases in pH were not found to alter fibroblast biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Effects of polyglycolic acid on porcine smooth muscle cell growth and differentiation

Higgins

Solan

Niklason

2003

J Biomedical Materials Res

125

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Polyglycolic acid (PGA) is commonly used as a scaffold for tissue engineering. Recent studies utilized PGA as a scaffold for vascular tissue engineering using bovine and porcine smooth muscle cells (SMCs). In engineered vessels, the SMCs displayed high rates of mitosis and dedifferentiation in areas where PGA fragments were present. We hypothesized that PGA breakdown products, sequestered within a SMC vessel at the conclusion of culture, led to increased proliferation and dedifferentiation of vascular SMCs. To test this hypothesis, the current study assessed possible means by which PGA breakdown products could lead to changes in SMC phenotype. SMCs grown in high concentrations of PGA breakdown products showed, by Western blotting, decreased expression of calponin, a marker for SMC differentiation. The same was true for SMCs grown in glycolic acid (GA), which also showed decreased expression of proliferating cell nuclear antigen (PCNA), a marker for SMC proliferation. In contrast, cells grown in varying amounts of NaCl or HCl showed little change in differentiation. We conclude that, independent of acidity or osmolality, plausible products of PGA degradation appear to induce dedifferentiation of porcine SMCs in vitro. Because of dedifferentiation and decreased mitosis, commercially available PGA may not represent an optimal scaffold for vascular tissue engineering.

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Short Contact 70% Glycolic Acid Peels as a Treatment for Photodamaged Skin A Pilot Study

Abstract: In this limited pilot study, no specific benefit could be assigned to the concomitant use of monthly glycolic acid refresher "peels" in the treatment of photodamaged skin.

Cited by 25 publications

References 1 publication

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Ultrastructural changes seen after ALA‐IPL photorejuvenation: A pilot study

Effects of polyglycolic acid on porcine smooth muscle cell growth and differentiation

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