Short contact with nickel causes allergic contact dermatitis: an experimental study

Ahlström, Malin G.; Thyssen, Jacob P.; Menné, Torkil; Midander, Klara; Julander, Anneli; Lidén, Carola; Johnsen, Carsten; Johansen, Jeanne Duus

doi:10.1111/bjd.16935

Cited by 35 publications

(41 citation statements)

References 22 publications

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“…Furthermore, the case shows that brief and repeated nickel skin contact at work can lead to nickel skin deposition and chronic hand eczema. The importance of this has recently been highlighted experimentally …”

Section: Discussionmentioning

confidence: 99%

Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

et al. 2019

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“…Although the current main causes of nickel allergy and dermatitis are presumed to be well‐known risk items such as earrings and jewellery, the widespread use of nickel may be of importance for the continuing high prevalence of nickel allergy . Recent reports have shown that various metallic items intended for short but repeated skin contact can lead to accumulation of nickel on the skin over time . These exposures may not be as obvious and may therefore not be studied to the same extent, which is why little is known about their clinical implications.…”

Section: Sources Of Nickel Exposurementioning

confidence: 99%

“…Nielsen et al showed a worsening of existing hand eczema in nickel‐allergic individuals after finger exposure for 10 minutes daily to 10 ppm and then 100 ppm nickel over a 2‐week period . In a recent study, it was shown that three 10‐minute exposures to metallic nickel discs led to elicitation of allergic nickel dermatitis in pre‐irritated skin in 10 of 16 nickel‐allergic individuals . Also, it has been shown that relatively short and repeated occupational skin contact with nickel can lead to hand eczema in nickel‐allergic individuals Nickel probably builds up on or in the skin after repeated contact at the same skin site.…”

Section: Thresholds For Nickel Allergymentioning

confidence: 99%

Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

et al. 2019

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Nickel is the most frequent cause of contact allergy worldwide and has been studied extensively. This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment. The implementation of a nickel regulation in Europe led to a decrease in the prevalence of nickel allergy, and changes in the clinical picture and disease severity. Nevertheless, the prevalences of nickel allergy in the European general population are approximately 8% to 19% in adults and 8% to 10% in children and adolescents, with a strong female predominance. Well‐known consumer items such as jewellery and metal in clothing are still the main causes of nickel allergy and dermatitis, although a wide range of items for both private and occupational use may cause dermatitis. Allergic nickel dermatitis may be localized to the nickel exposure site, be more widespread, or present as hand eczema. Today, efficient methods for exposure quantification exist, and new insights regarding associated risk factors and immunological mechanisms underlying the disease have been obtained. Nevertheless, questions remain in relation to the pathogenesis, the persistent high prevalence, and the treatment of severe cases.

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“…Nickel is toxic to humans. It frequently elicits contact allergy acting via skin exposure to materials releasing this metal . Unfortunately, many objects of daily use, such as tools, coins, jewelry, or cases of mobile phones and laptops release nickel in amounts high enough to trigger a reaction of the human immune system .…”

Section: Introductionmentioning

confidence: 99%

Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence

Frączyk

Bonna

Stefaniak

et al. 2020

Chemistry & Biodiversity

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Nickel is harmful to humans, being both carcinogenic and allergenic. However, the mechanisms of this toxicity are still unresolved. We propose that Ni(II) ions disintegrate proteins by hydrolysis of peptide bonds preceding the Ser/Thr‐Xaa‐His sequences. Such sequences occur in nuclear localization signals (NLSs) of human phospholipid scramblase 1, Sam68‐like mammalian protein 2, and CLK3 kinase. We performed spectroscopic experiments showing that model nonapeptides derived from these NLSs bind Ni(II) at physiological pH. We also proved that these sequences are prone to Ni(II) hydrolysis. Thus, the aforementioned NLSs may be targets for nickel toxicity. This implies that Ni(II) ions disrupt the transport of some proteins from cytoplasm to cell nucleus.

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Short contact with nickel causes allergic contact dermatitis: an experimental study

Abstract: This experimental study showed that relatively short repeated skin contact (3 × 10 min) with metallic nickel elicits allergic nickel dermatitis in irritated skin and at sites with previous dermatitis. The results support the restrictions in current nickel regulation.

Cited by 35 publications

References 22 publications

Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence

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