Short intracortical facilitation associates with motor-inhibitory control

Ding, Qi; Cai, Huiting; Wu, Manfeng; Cai, Guiyuan; Chen, Hongying; Li, Wanqi; Lin, Tuo; Jing, Yinghua; Yuan, Ti‐Fei; Xu, Gelin; Lan, Yue

doi:10.1016/j.bbr.2021.113266

Cited by 10 publications

(19 citation statements)

References 72 publications

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“…RMT was determined as the minimum intensity required to evoke 5 out of 10 MEPs greater than 50 μV at rest ( Chen et al, 1998 ). A neuronavigation system (Visor2, ANT Neuro, Hengelo, Netherlands) was used to ensure consistent coil positioning over the optimal scalp position (i.e., motor hotspot) throughout the experiment ( Ding et al, 2021a , c ). For the individuals in whom MEPs in the IH cannot be elicited even with 100% MSO ( n = 6 in the Active iTBS group and n = 5 in the Sham iTBS group), RMT in the IH was considered as 100% maximum stimulator output (MSO).…”

Section: Methodsmentioning

confidence: 99%

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Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study

Ding

Chen

et al. 2022

Front. Aging Neurosci.

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ObjectiveIntermittent theta burst stimulation (iTBS) has been widely used as a neural modulation approach in stroke rehabilitation. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS-EEG) offers a chance to directly measure cortical reactivity and oscillatory dynamics and allows for investigating neural effects induced by iTBS in all stroke survivors including individuals without recordable MEPs. Here, we used TMS-EEG to investigate aftereffects of iTBS following stroke.MethodsWe studied 22 stroke survivors (age: 65.2 ± 11.4 years; chronicity: 4.1 ± 3.5 months) with upper limb motor deficits. Upper-extremity component of Fugl-Meyer motor function assessment and action research arm test were used to measure motor function of stroke survivors. Stroke survivors were randomly divided into two groups receiving either Active or Sham iTBS applied over the ipsilesional primary motor cortex. TMS-EEG recordings were performed at baseline and immediately after Active or Sham iTBS. Time and time-frequency domain analyses were performed for quantifying TMS-evoked EEG responses.ResultsAt baseline, natural frequency was slower in the ipsilesional compared with the contralesional hemisphere (P = 0.006). Baseline natural frequency in the ipsilesional hemisphere was positively correlated with upper limb motor function following stroke (P = 0.007). After iTBS, natural frequency in the ipsilesional hemisphere was significantly increased (P < 0.001).ConclusionsThis is the first study to investigate the acute neural adaptations after iTBS in stroke survivors using TMS-EEG. Our results revealed that natural frequency is altered following stroke which is related to motor impairments. iTBS increases natural frequency in the ipsilesional motor cortex in stroke survivors. Our findings implicate that iTBS holds the potential to normalize natural frequency in stroke survivors, which can be utilized in stroke rehabilitation.

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Section: Methodsmentioning

confidence: 99%

“…TMS was performed using a NS5000 Magnetic Stimulator (YIRUIDE Medical Co., Wuhan, China) (biphasic pulses, pulse width = 350 ms). A neuronavigation system (Visor2, ANT Neuro, Hengelo, Netherlands) was used during the application of TMS ( Ding et al, 2021a ).…”

Section: Methodsmentioning

confidence: 99%

Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study

Ding

Chen

et al. 2022

Front. Aging Neurosci.

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“…RMT was determined experimentally as the lowest stimulation intensity that produced MEP greater than 50 µV in at least 50% of consecutive stimulations at rest (Chen et al, 1998). A neuronavigation system (Visor2, ANT Neuro, Hengelo, Netherlands) was used to ensure reliable and consistent coil positioning over the "hotspot" throughout the experiment (Ding et al, 2021a).…”

Section: Intermittent Theta Burst Stimulationmentioning

confidence: 99%

The Effects of Intermittent Theta Burst Stimulation on Functional Brain Network Following Stroke: An Electroencephalography Study

et al. 2021

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Objective: Intermittent theta burst stimulation (iTBS) is a special form of repetitive transcranial magnetic stimulation (rTMS), which effectively increases cortical excitability and has been widely used as a neural modulation approach in stroke rehabilitation. As effects of iTBS are typically investigated by motor evoked potentials, how iTBS influences functional brain network following stroke remains unclear. Resting-state electroencephalography (EEG) has been suggested to be a sensitive measure for evaluating effects of rTMS on brain functional activity and network. Here, we used resting-state EEG to investigate the effects of iTBS on functional brain network in stroke survivors.Methods: We studied thirty stroke survivors (age: 63.1 ± 12.1 years; chronicity: 4.0 ± 3.8 months; UE FMA: 26.6 ± 19.4/66) with upper limb motor dysfunction. Stroke survivors were randomly divided into two groups receiving either Active or Sham iTBS over the ipsilesional primary motor cortex. Resting-state EEG was recorded at baseline and immediately after iTBS to assess the effects of iTBS on functional brain network.Results: Delta and theta bands interhemispheric functional connectivity were significantly increased after Active iTBS (P = 0.038 and 0.011, respectively), but were not significantly changed after Sham iTBS (P = 0.327 and 0.342, respectively). Delta and beta bands global efficiency were also significantly increased after Active iTBS (P = 0.013 and 0.0003, respectively), but not after Sham iTBS (P = 0.586 and 0.954, respectively).Conclusion: This is the first study that used EEG to investigate the acute neuroplastic changes after iTBS following stroke. Our findings for the first time provide evidence that iTBS modulates brain network functioning in stroke survivors. Acute increase in interhemispheric functional connectivity and global efficiency after iTBS suggest that iTBS has the potential to normalize brain network functioning following stroke, which can be utilized in stroke rehabilitation.

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“…Participants were asked to stop their initial response when the "Stop" signal occurred. Participants were instructed to respond as quickly and accurately as possible to black arrows, and not to delay their response to wait in case the "Stop" signal occurred (Ding et al, 2021a).…”

Section: Stop Signal Taskmentioning

confidence: 99%

“…The experiment included 24 practice trials and 400 experimental trials, consisting of 70% "Go" trials, 10% "Nogo" trials, and 20% "Stop" trials, administered in a completely random sequence. The details of SST were described in a previous paper (Ding et al, 2021a).…”

Section: Stop Signal Taskmentioning

confidence: 99%

Individual differences in beta-band oscillations predict motor-inhibitory control

Ding

Lin²,

Cai³

et al. 2023

Front. Neurosci.

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ObjectiveThe ability of motor-inhibitory control is critical in daily life. The physiological mechanisms underlying motor inhibitory control deficits remain to be elucidated. Beta band oscillations have been suggested to be related to motor performance, but whether they relate to motor-inhibitory control remains unclear. This study is aimed at systematically investigating the relationship between beta band oscillations and motor-inhibitory control to determine whether beta band oscillations were related to the ability of motor-inhibitory control.MethodsWe studied 30 healthy young adults (age: 21.6 ± 1.5 years). Stop-signal reaction time (SSRT) was derived from stop signal task, indicating the ability of motor-inhibitory control. Resting-state electroencephalography (EEG) was recorded for 12 min. Beta band power and functional connectivity (including global efficiency) were calculated. Correlations between beta band oscillations and SSRT were performed.ResultsBeta band EEG power in left and right motor cortex (MC), right somatosensory cortex (SC), and right inferior frontal cortex (IFC) was positively correlated with SSRT (P’s = 0.031, 0.021, 0.045, and 0.015, respectively). Beta band coherence between bilateral MC, SC, and IFC was also positively correlated with SSRT (P’s < 0.05). Beta band global efficiency was positively correlated with SSRT (P = 0.01).ConclusionThis is the first study to investigate the relationship between resting-state cortical beta oscillations and response inhibition. Our findings revealed that individuals with better ability of motor inhibitory control tend to have less cortical beta band power and functional connectivity. This study has clinical significance on the underlying mechanisms of motor inhibitory control deficits.

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Short intracortical facilitation associates with motor-inhibitory control

Cited by 10 publications

References 72 publications

Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study

Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study

The Effects of Intermittent Theta Burst Stimulation on Functional Brain Network Following Stroke: An Electroencephalography Study

Individual differences in beta-band oscillations predict motor-inhibitory control

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