Short-latency effect of testosterone on copulatory behaviour and ejaculation in sexually experienced intact male rats

Malmnäs, Carl Olof

doi:10.1530/jrf.0.0510351

Cited by 46 publications

(16 citation statements)

References 12 publications

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“…Although this confound was acknowledged and discounted, the testosterone treatment nonetheless could have affected estradiol responsiveness but not vice versa. The ineffectiveness of testosterone, compared to the previous study [49], may have been due to the males' castrated status.…”

Section: Copulatory Behaviormentioning

confidence: 55%

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Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Nyby

2008

Frontiers in Neuroendocrinology

100

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Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and may serve to activate transitory motivational and physiological responses that facilitate reproduction. However, such a function requires that testosterone be working through either nongenomic, or very quick genomic, mechanisms. The first part of the review describes reflexive sex hormone release in house mice. The second part summarizes research implicating testosterone's fast actions in affecting anxiety, reward, learning, analgesia, and penile reflexes in rodents, all of which could optimize male mating success. The review concludes with a speculative model of how spontaneous and reflexive hormone release might interact to regulate reproductive behavior and why mice appear to be an ideal species for examining testosterone's quick effects.

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Section: Copulatory Behaviormentioning

confidence: 55%

“…Consistent with these shortened latencies being caused by testosterone, gonadally intact male rats injected i.p. with 100 μg of testosterone (simulating a testosterone pulse) exhibited shortened intromission and ejaculation latencies 1 hr after injection [49].…”

Section: Copulatory Behaviormentioning

confidence: 99%

Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Nyby

2008

Frontiers in Neuroendocrinology

100

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“…However, a short-latency effect of testosterone on copulatory behavior occurs when testosterone is applied to intact male rats [47] . The ineffectiveness of testosterone in the study of Cross and coauthors might have been due to the castrated status of the males.…”

Section: Discussionmentioning

confidence: 99%

Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

et al. 2015

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Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

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“…However, the underlying mechanism of the behavioral effects of such rapid hormonal changes has not been identified. It has been shown that an injection of testosterone given to a sexually experienced and intact male rat one hour before he was allowed to copulate with a female decreased the inter-intromission interval and facilitated ejaculation [157]. Similarly, testosterone also affects penile reflexes of rats in a rapid manner (within 6 to 30 min; [218]).…”

Section: Gonadal Production Of Steroidsmentioning

confidence: 99%

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

2006

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Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, mounting evidence highlights the functional significance of non-genomic effects. However, the source of the rapid changes in estrogen availability that are necessary to sustain their fast actions is rarely questioned. For example, the rise of plasma estrogens at pro-estrus that represents one of the fastest documented changes in plasma estrogen concentration appears too slow to explain these actions. Alternatively, estrogen can be synthesized in the brain by the enzyme aromatase providing a source of locally high concentrations of the steroid. Furthermore, recent studies demonstrate that brain aromatase can be rapidly modulated by afferent inputs, including glutamatergic afferents. A role for rapid changes in estrogen production in the central nervous system is supported by experiments showing that acute aromatase inhibition affects nociception as well as male sexual behavior and that preoptic aromatase activity is rapidly (within min) modulated following mating. Such mechanisms thus fulfill the gap existing between the fast actions of estrogen and their mode of production and open new avenues for the understanding of estrogenic effects on the brain.

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Short-latency effect of testosterone on copulatory behaviour and ejaculation in sexually experienced intact male rats

Cited by 46 publications

References 12 publications

Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Reflexive testosterone release: A model system for studying the nongenomic effects of testosterone upon male behavior

Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

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