Short ReportGenetic variation at three VNTR loci (D1S80, APOB and D17S5) in two tribal populations of Andhra Pradesh, India

Sachdeva, M.P.; Mastana, Sarabjit S.; Saraswathy, Kallur Nava; Elizabeth, A.M.; Chaudhary, Rubina; Kalla, A.K.

doi:10.1080/03014460310001625978

Cited by 5 publications

(3 citation statements)

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“…Both minisatellites and microsatellites are highly variable, polymorphic, co-dominant and heterozygous and thus are excellent tools for genetic individualization and population genetic studies (Papiha et al 1996a;Das et al 2002;Mastana and Singh, 2002;Das and Mastana, 2003;Ranjan et al 2003;Agrawal et al 2003;Sachdeva et al 2004;Kashyap et al 2004Kashyap et al , 2006Mastana et al 2007;Khan et al 2008). Chakraborty (1990) suggested that even a single minisatellite locus could provide information concerning sub-structuring within a population with a statistical power greater than several classical genetic markers studied simultaneously.…”

Section: Repeat Length Polymorphismsmentioning

confidence: 99%

Unity in diversity: an overview of the genomic anthropology of India

Mastana

2014

Annals of Human Biology

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Context: India is considered a treasure for geneticists and evolutionary biologists due to its vast human diversity, consisting of more than 4500 anthropologically well-defined populations (castes, tribes and religious groups). Each population differs in terms of endogamy, language, culture, physical features, geographic and climatic position and genetic architecture. These factors contributed to India-specific genetic variations which may be responsible for various common diseases in India and its migratory populations.As a result, interpretations of the origins and affinities of Indian populations as well as health and disease conditions require complex and sophisticated genetic analysis.Evidence of ancient human dispersals and settlements is preserved in the genome of Indian inhabitants and this has been extensively analysed in conventional and genomic analyses.Objective and Methods: Using genomic analyses of STRs and Alu on a set of populations, we estimate the level and extent of genetic variation and its implications.Results: The results show that Indian populations have higher level of unique genetic diversity which is structured by many social processes and geographical attributes of the country.Conclusion: This overview highlights the need to study the anthropological structure and evolutionary history of Indian populations while designing genomic and epigenomic investigations.

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Section: Repeat Length Polymorphismsmentioning

confidence: 99%

Unity in diversity: an overview of the genomic anthropology of India

Mastana

2014

Annals of Human Biology

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“…We did not observe allele 23 in this study, but it was observed at a frequency of 0.007 by Akgunes et al (2002) and 0.009 by Ç akir et al (2001). Sachdeva et al (2004) showed higher frequencies of allele 31 in Thoti and Kolam populations (9-14%) than in other Indian populations.…”

Section: Discussionmentioning

confidence: 76%

Allele Frequency of VNTR Locus D1S80 Observed in Denizli Province of Turkey

Köseler

Atalay

2009

Biochem Genet

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The variable numbers of tandem repeats (VNTR) locus D1S80, located on chromosome 1 (1p35-36), has a repeat unit 16 bp in length, and different numbers of these repeat units have been observed for populations of different origins and ethnicity. We used a molecular identification method based on capillary electrophoresis separation to analyze D1S80 locus polymorphism among 74 subjects from Denizli province, Turkey, finding an amplified fragment length size of 379-635 bp. Allele repeat numbers were deduced from these sizes and sequence comparison. The most common alleles were repeat units 24 (34.3%) and 18 (22.4%), with frequencies of 0.414 and 0.207, respectively. Other alleles were 25 (7.86%), 28 (5.71%), 22 (4.25%), and 29 (2.86%). The allele with 23 repeat units was not observed. Results were in Hardy-Weinberg linkage disequilibrium. Observed heterozygosity was 0.614, and expected heterozygosity was 0.787. Theta(k) value was 4.86 (95% confidence interval limits). Capillary electrophoresis is a powerful approach for accurate identification of VNTR loci, especially for low base pair units like D1S80, for prenatal diagnosis, linkage analysis, forensic identification, paternity testing, anthropological research, and phylogenetic studies.

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“…D1S80 allele frequencies were studied in a large number of populations worldwide. In this study, 76 different population data (including the data presented in this study) (Al-Nassar et al, 1996;Alkhayat et al, 1996;Balamurugan et al, 2001;Bernal et al, 2000;Cabrero et al, 1995;Çakir et al, 2001;Cerda-Flores et al, 2002;Ciesielka et al, 1996;Das and Seshadri, 2004;Gutowski et al, 1995;Halos et al, 1999;Herrera et al, 2004;Keys et al, 1996;Lorentea et al, 1997;Mastana, 1999;Matamoros et al, 2004;Morales et al, 2001;Ruangjirachuporn et al, 2006;Sachdeva et al, 2004;Sajib et al, 2016;Soares-Vieira et al, 2000;Tenaglia et al, 2004;Trivedi et al, 2002;Vallinoto et al, 2003;Verbenko et al, 2006;Yunis et al, 2001) were fed into POPTREE2 and a phylogenetic tree was constructed following neighbor-joining (NJ) method (Figure 1). Phylogenetic analysis based on the D1S80 alleleic profiles placed the four indigenous populations along with the mainstream Bangladeshis, the north Indian Tamils and the mixed Panjabi Indians in a clade separated from the rest.…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphism study at D1S80 VNTR in four major tribal populations (Garo, Santal, Khasia and Monipuri) of Bangladesh

Sajib

Hasan

et al. 2016

Asian Australas. J. Biosci. Biotechnol.

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D1S80 is a highly informative variable number of tandem repeat (VNTR) marker located in the telomeric region of chromosome 1 at 1p36-p35. Since its discovery, the D1S80 locus has been used widely in determining the origins and genetic relations among and between various populations worldwide. Here, we studied the allele frequencies and other population genetic parameters at the D1S80 locus among individuals from four major tribal populations in Bangladesh (Santal, Garo, Monipuri and Khasia). The data was then compared with the other populations including the mainstream Bengali population. A total of 31 different alleles were detected with repeat unit numbers ranging between 14 and 50. D1S80 allele with 18 repeats was the most frequent in three populations except the Santals, in which allele with 19 repeats was the most common. Observed heterozygosity was less than the expected in all four populations. Pair-wise observed genetic distances were, in general, more between the tribal populations and the mixed mainstream Bangladeshis compared to the distances between the tribal populations. Comparison of D1S80 allelic frequency distribution among seventy-six different populations placed the tribal populations along with the mainstream mixed Bangladeshis, Tamils and mixed Panjabi Indians in a clade separated from the rest. Asian Australas. J. Biosci. Biotechnol. 2016, 1 (2), 386-393

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Short ReportGenetic variation at three VNTR loci (D1S80, APOB and D17S5) in two tribal populations of Andhra Pradesh, India

Cited by 5 publications

References 9 publications

Unity in diversity: an overview of the genomic anthropology of India

Unity in diversity: an overview of the genomic anthropology of India

Allele Frequency of VNTR Locus D1S80 Observed in Denizli Province of Turkey

Genetic polymorphism study at D1S80 VNTR in four major tribal populations (Garo, Santal, Khasia and Monipuri) of Bangladesh

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