Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy

Seo, Hee Seung; Wang, Chi‐Pin James; Park, Wooram; Park, Chun Gwon

doi:10.1007/s13770-021-00369-6

Cited by 16 publications

(5 citation statements)

References 148 publications

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“…However, in this review article, the goal was to contextualize the current situation and challenges for hydrogel engineering for biomedical applications, as well as to compile the current trends in this field, with the premise that novel hydrogels with stronger and more stable properties are still needed and remain an important direction for research [ 33 ]. As was previously mentioned for TE, due to their properties and their ability to mimic ECM properties, hydrogels are suitable candidates for many biomedical applications, such as controlled drug release and wound healing, which are among the most well-known possible applications where hydrogels are posed as a promising solution [ 34 , 35 , 36 , 37 ]. Therefore, the objective of this review was to update and summarize current trends in applications and advances in hydrogel science, by means of the most used materials and synthesis methods for hydrogel manufacture, as well as different strengthening strategies, such as compositional modifications, different cross-linking techniques and hybridization.…”

Section: Introductionmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Introductionmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…), and their combination (e.g., collagen/matrigel, gelatin/alginate). Due to their highly porous construction, they form an extracellular matrix (ECM)-like structure that provides a stable repository for immunotherapy agents without damaging their biological activity [ 161 ]. The first immunotherapeutic application of hydrogels was in 2008, when DCs were injected into an injectable hydrogel matrix.…”

Section: Adjuvants and Formulationmentioning

confidence: 99%

“…Peptide-based hydrogels can be successfully used for cancer immunotherapy, they can deliver cytokines, anticancer vaccines, checkpoint inhibitors, and chimeric antigen receptor (CAR)-T cells [ 161 ]. Wakabayashi et al developed a solid-in-oil nanodispersion carrier system for hydrophilic molecules.…”

Section: Adjuvants and Formulationmentioning

confidence: 99%

“…An excellent example of the combination of two kinds of delivery systems was introduced by Wang et al They combined a four-arms PEG moiety with an injectable supramolecular hydrogel to form an effective delivery system for transferring adenovirus encoding Flagrp170 (a chimeric molecule which induces inflammatory cytokines, such as TNF-α and IFN-γ). The hydrogel-mediated release of the adenovirus vector resulted in an effective delivery of tumor antigens to target antigen-presenting cells and showed increased therapeutic efficacy in murine melanoma models [ 161 , 177 ].…”

Section: Adjuvants and Formulationmentioning

confidence: 99%

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Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy

Bánóczi

Szabó

2023

Pharmaceutics

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Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths. Since the start of deeper insight into the mechanisms of melanoma tumorigenesis and their strong interaction with the immune system, the development of new therapeutical strategies has been continuously rising. The high number of melanoma cell mutations provides a diverse set of antigens that the immune system can recognize and use to distinguish tumor cells from normal cells. Peptide-based synthetic anti-tumor vaccines are based on tumor antigens that elicit an immune response due to antigen-presenting cells (APCs). Although targeting APCs with peptide antigens is the most important assumption for vaccine development, peptide antigens alone are poorly immunogenic. The immunogenicity of peptide antigens can be improved not only by synthetic modifications but also by the assistance of adjuvants and/or delivery systems. The current review summarizes the different chemical approaches for the development of effective peptide-based vaccines for the immunotherapeutic treatment of advanced melanoma.

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“…Notably, implantable drug delivery systems have been researched, with hydrogels emerging as potential biomaterials for facilitating innovative drug delivery strategies [ 20 , 21 ]. Hydrogels have consistently demonstrated advantageous properties, such as low toxicity, high loading efficacy, stimuli responsiveness, and in situ gel-forming ability [ 22 , 23 ]. These favorable characteristics indicate that hydrogels can be a potential delivery approach that significantly enhances cancer/immune cell targeting, boosts immune responses, and reduces systemic toxicity and adverse side effects associated with immunotherapy [ 24 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy

Seo,

Han,

Lim

et al. 2024

Biomater Res

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Background: Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan to address these issues. Glycol chitosan is a natural adjuvant, inducing dendritic cell activation to promote T helper 1 cell immune responses, macrophage activation, and cytokine production. Effective antigen production by dendritic cells initiates T-cell-mediated immune responses, aiding tumor growth control. Methods: In this study, we fabricated multifunctional methacrylated glycol chitosan (MGC) hydrogels with extended release of DNA/doxorubicin (DOX) complex for cancer immunotherapy. We constructed the resection model of breast cancer to verify the anticancer effects of MGC hydrogel with DNA/DOX complex. Results: This study demonstrated the potential of MGC hydrogel with extended release of DNA/DOX complex for local and efficient cancer therapy. The MGC hydrogel was implanted directly into the surgical site after tumor resection, activating tumor-related immune cells both locally and over a prolonged period of time through immune-reactive molecules. Conclusions: The MGC hydrogel effectively suppressed tumor recurrence and metastasis while enhancing immunotherapeutic efficacy and minimizing side effects. This biomaterial-based drug delivery system, combined with cancer immunotherapy, can substantial improve treatment outcomes and patient prognosis.

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Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy

Cited by 16 publications

References 148 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy

Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy

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