Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study

Deng, Han‐Bing; Tam, Tony; Zee, Benny; Chung, Roger Yat‐Nork; Su, Xing; Jin, Lei; Chan, Ta‐Chien; Chang, Li-Yuan; Yeoh, Eng‐Kiong; Lao, Xiang Qian

doi:10.1093/sleep/zsx130

Cited by 89 publications

(88 citation statements)

References 42 publications

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“…Sleep comprises approximately one‐third of our lifetime and is an essential physiological function indispensable for survival. In our 24/7 lifestyle of modern society sleep duration has been significantly reduced and more people experience insufficient sleep (Deng et al., ). Sleep deprivation has been shown to impact metabolism and immune systems, leading to increased incidence of obesity, impaired glucose tolerance, metabolic syndrome and cardiovascular disease (Huang, Ramsey, Marcheva, & Bass, ; Johnston, ; Scheer, Hilton, Mantzoros, & Shea, ; Spiegel, Knutson, Leproult, Tasali, & Van Cauter, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females

Honma

Revell

Gunn

et al. 2019

Eur J of Neuroscience

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Disruption to sleep and circadian rhythms can impact on metabolism. The study aimed to investigate the effect of acute sleep deprivation on plasma melatonin, cortisol and metabolites, to increase understanding of the metabolic pathways involved in sleep/wake regulation processes. Twelve healthy young female participants remained in controlled laboratory conditions for ~92 hr with respect to posture, meals and environmental light (18:00–23:00 hr and 07:00‐09:00 hr <8 lux; 23:00–07:00 hr 0 lux (sleep opportunity) or <8 lux (continuous wakefulness); 09:00–18:00 hr ~90 lux). Regular blood samples were collected for 70 hr for plasma melatonin and cortisol, and targeted liquid chromatography–mass spectrometry metabolomics. Timepoints between 00:00 and 06:00 hr for day 1 (baseline sleep), day 2 (sleep deprivation) and day 3 (recovery sleep) were analysed. Cosinor analysis and MetaCycle analysis were performed for detection of rhythmicity. Night‐time melatonin levels were significantly increased during sleep deprivation and returned to baseline levels during recovery sleep. No significant differences were observed in cortisol levels. Of 130 plasma metabolites quantified, 41 metabolites were significantly altered across the study nights, with the majority decreasing during sleep deprivation, most notably phosphatidylcholines. In cosinor analysis, 58 metabolites maintained their rhythmicity across the study days, with the majority showing a phase advance during acute sleep deprivation. This observation differs to that previously reported for males. Our study is the first of metabolic profiling in females during sleep deprivation and recovery sleep, and offers a novel view of human sleep/wake regulation and sex differences.

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Section: Introductionmentioning

confidence: 99%

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females

Honma

Revell

Gunn

et al. 2019

Eur J of Neuroscience

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“…Several studies have linked sleep duration to high blood pressure [21][22]. There are many studies on adult sleep duration and hypertension, and there are few studies on children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Sleep Duration, Body Mass Index, Physical Education Classes, Age and High Blood Pressure in Children and Adolescents: A Cross-sectional Study

Cao¹,

Li²,

Zhang³

2020

Preprint

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Background In order to study the high blood pressure of children and adolescents and its influencing factors, it provides evidence-based evidence for the high blood pressure prevention of primary and secondary school students. Methods This study is a cross-sectional survey, which uses stratified cluster sampling method to select students from 7 schools to participate in questionnaire survey and physical examination. The correlation between single factor and high blood pressure was analyzed by chi-square test, and multivariate logistic regression analysis was used for multivariate analysis. Results A total of 1,814 subjects, including 512 primary school students (28.22%), 499 junior high school students (27.51%), 563 senior high school (31.04%), and 240 vocational high school (13.23%). There were 1000 males (55.13%) and 814 females (44.70%). The average age was 13.64±2.65 years. The detection rate of high blood pressure was 9.76%. Multivariate logistic regression analysis showed that the age groups were 10~ and 14~ (OR=20.870, 95%CI=2.372-183.666; OR=10.049, 95%CI=1.306-77.353) , sleep duration < 7h (OR=4.136, 95%CI=4.136), and physical education class times ≤2 times per week (OR=5.073, 95%CI=2.497-10.306), which were risk factors for high blood pressure in children and adolescents. Normal weight and overweight group were protective factors compared to the obesity group (OR=0.094, 95%CI=0.061-0.146; OR=0.225, 95%CI=0.134-0.378). Conclusion The age groups of 14~ and 16~ years old, physical education classes ≤ 2 times per week, and sleep duration <7h were risk factors for primary and secondary school students, and BMI of Normal weight and overweight group were protective factors compared to the obesity group students.

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“…In non-pregnant populations, disrupted sleep is related to various negative health consequences, such as increased risk for diabetes, elevated blood pressure and obesity [59,60]. Growing evidence suggests that also maternal prenatal sleep disturbances may indicate an increased risk for pregnancy and delivery complications.…”

Section: Discussionmentioning

confidence: 99%

Maternal tiredness and cytokine concentrations in mid-pregnancy

Kaartinen

Karlsson

Paavonen

et al. 2019

Journal of Psychosomatic Research

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Sleep disturbances relate to altered levels of inflammatory mediators in general population, but not much is known about the associations between sleep disturbances and inflammatory mediators during pregnancy. The present exploratory study investigated whether insomnia, tiredness, general sleep quality, and insufficient sleep duration during pregnancy relate to the concentrations of maternal peripheral circulating cytokines. As sleep disturbances are frequently observed in mood disorders, the results were controlled for symptoms of depression and anxiety. Methods: 137 participants were randomly drawn from a representative FinnBrain Birth Cohort. Serum concentrations of selected cytokines were analyzed using Multiplex bead arrays from blood samples drawn at the gestational week 24. The sleep disturbances were evaluated using the Basic Nordic Sleep Questionnaire. Depressive and anxiety symptoms were measured with the Edinburgh Postnatal Depression Scale and the anxiety subscale of the self-rated Symptom Checklist 90, respectively. Results: Enhanced tiredness was associated with cytokine concentrations of IL-2, IL-10, IL-12, IL-13, and TNF-α. The observed associations resembled a reversed U-shaped curve rather than being linear. Having a good general sleep quality was associated with higher logarithmic cytokine concentrations of IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, and IFN-γ. There was no evidence for associations between insomnia or sleep loss and cytokines. Conclusions: Maternal subjective tiredness and good general sleep quality were associated with altered levels of immunological markers during pregnancy. The association was independent from symptoms of depression and anxiety. wake hours [5,6]. Increased rates of fatigue and sleepiness are frequently observed throughout normally progressing pregnancies [4,6,7]. Reportedly, women also take more naps during pregnancy compared to non-pregnant women [3,4]. Cytokines are signaling proteins of the immune system that are stimulated by infections and other types of inflammation, psychological stress, as well as sleep disturbances [8-14]. Cytokines may be further divided into proinflammatory T-helper 1 lymphocyte produced cytokines (Th1 cytokines, such as IFN-γ, IL-6, and IL-12) and anti

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Short Sleep Duration Increases Metabolic Impact in Healthy Adults: A Population-Based Cohort Study

Abstract: Sleep duration may be a significant determinant of metabolic health.

Cited by 89 publications

References 42 publications

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females

Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females

The Relationship between Sleep Duration, Body Mass Index, Physical Education Classes, Age and High Blood Pressure in Children and Adolescents: A Cross-sectional Study

Maternal tiredness and cytokine concentrations in mid-pregnancy

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