Short-term Administration of Water-soluble Silicon Improves Mineral Density of the Femur and Tibia in Ovariectomized Rats

Bae, Yun‐Jung; Kim, Jae‐Young; Choi, Mi‐Kyeong; Chung, Yoon‐Sok; Kim, Mi‐Hyun

doi:10.1007/s12011-008-8138-3

Cited by 31 publications

(13 citation statements)

References 22 publications

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“…Ovariectomy significantly increased the final body weights in the OVX control (389.56 ± 27.01 g) after 15 weeks ( p < 0.01), compared with the normal (331.92 ± 24.63 g) and sham groups (309.49 ± 23.99 g). The oral administrations of estradiol and fucosterol group weight gain were significantly decreased to 29.1%, 25.5% compared to OVX group (Table ), which is similar to data; both estradiol and fucosterol had preventing activity on ovariectomy‐induced increasing of body weight .…”

Section: Resultssupporting

confidence: 85%

The bone regenerative effects of fucosterol in in vitro and in vivo models of postmenopausal osteoporosis

Lee

Park

Chung

et al. 2014

Mol. Nutr. Food Res.

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Scope:The aim of this study was to investigate the bone regenerative effects of fucosterol in estrogen-deficient ovariectomized (OVX) rats. Methods and results: Bone regeneration was assessed in fucosterol-treated MG63 cells in vitro via assays for osteoblast proliferation, alkaline phosphatase, and osteoclast differentiation. Osteoblast proliferation rates, alkaline phosphatase activity, and mineralization were increased in the fucosterol-treated group. Moreover, differentiation of osteoclasts was decreased in the fucosterol-treated group. In the in vivo assay, female rats were OVX. Twelve weeks after ovariectomy, rats were divided into seven groups, each oral administrate everyday for 7 weeks. The bone mineral density of femoral bones was higher in fucosterol groups than in OVX control, and body weight was lower in fucosterol groups. Among bone-quality parameters, bone volume/total volume increased and trabecular separation decreased in fucosterol groups relative to the OVX control. Bone formation and resorption were evaluated using the serum biomarkers osteocalcin and CTx. Fucosterol tripled the level of serum osteocalcin relative to the OVX group and reduced the serum level of CTx. Conclusion: These results suggest that fucosterol has the dual potentials to activate osteoblasts to stimulate bone formation and suppress differentiation of osteoclasts so as to reduce bone resorption.

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Section: Resultssupporting

confidence: 85%

The bone regenerative effects of fucosterol in in vitro and in vivo models of postmenopausal osteoporosis

Lee

Park

Chung

et al. 2014

Mol. Nutr. Food Res.

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“…and in unfiltered drinking water [5]. In our previous research, we found that 4 weeks of oral Si administration (20 mg/kg body weight per day) in ovariectomized rats resulted in an increase in the bone densities of both the femoral neck and tibia [6]. Similar results were also observed in the study of Rico et al [7] wherein ovariectomized rats were fed a Si supplement (500 mg Si/kg of feed) for 30 days.…”

Section: Introductionsupporting

confidence: 79%

Silicon Supplementation Improves the Bone Mineral Density of Calcium-Deficient Ovariectomized Rats by Reducing Bone Resorption

Kim

Bae

Choi

et al. 2008

Biol Trace Elem Res

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The purpose of this study was to investigate the effect of silicon (Si) supplementation on bone mineral density (BMD) and bone metabolism parameters relative to calcium (Ca) intake levels in ovariectomized rats. A total of 72 female Wistar rats (6 weeks) were ovariectomized (OVX) and divided into six groups, and Si (500 mg of Si per kilogram of feed) was or was not administered with diets containing various levels of Ca (0.1%, 0.5%, and 1.5%) for 10 weeks. The groups were as follows: (1) Ca-deficient group (0.1% Ca), (2) Ca-deficient with Si supplementation group, (3) adequate Ca group (0.5% Ca), (4) adequate Ca with Si supplementation group, (5) high Ca group (1.5% Ca), and (6) high Ca with Si supplementation group. Si supplementation significantly increased the BMD of the femur and tibia in Ca-deficient OVX rats, while no change was observed with Si supplementation in the BMD of the spine, femur, and tibia in the adequate and high Ca groups. Serum alkaline phosphatase and osteocalcin levels were not affected by Si supplementation or Ca intake levels. C-telopeptide type I collagen levels were significantly decreased as a result of Si supplementation in Ca-deficient OVX rats. In summary, Si supplementation produced positive effects on bone mineral density in Ca-deficient OVX rats by reducing bone resorption. Therefore, Si supplementation may also prove to be helpful in preventing osteoporosis in postmenopausal women whose calcium intake is insufficient.

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“…[16][17][18] The trace mineral silicon is the second most abundant element on earth and it is present in all body tissues, particularly high in bone and connective tissues. 22,23 Meanwhile, magnesium plays an important role in the development of bone tissue via promoting the adhesion and growth of osteoblasts. 21 It is well known that silicon supplementation can improve bone mineral density and bone metabolism in ovariectomized rats.…”

Section: Introductionmentioning

confidence: 99%

Achieving accelerated osteogenic differentiation via novel magnesium silicate hollow spheres

Wang

Liu

et al. 2015

New J. Chem.

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Nanomaterials have been widely used as multifunctional scaffolds and carriers in bone tissue engineering resulting from their versatile functionalities. Here, a classical Stöber method that combined the merits of an organic reagent-free hydrothermal route was introduced to rationally design and synthesize novel magnesium silicate hollow spheres (denoted as MgSiO 3 hollow spheres). Due to the presence of mineral elements including silicon and magnesium, these well-prepared hollow structures exhibited positive effects in accelerated osteogenic differentiation. By using an osteoblastic cell line as example, namely MC3T3-E1, we investigated the in vitro toxicity of these hollow spheres via various classical methods including MTT assay, LDH assay, apoptosis, and morphology observation. Results indicated that these materials revealed extremely low systemic toxicity and high bio-compatibility. Moreover, cellular internalization observation demonstrated that these hollow spheres could be taken up by MC3T3-E1 cells in a time-dependent manner. This vigorous process of endocytosis could provide more raw materials for the following intracellular mineralization and bone regeneration. Results of ALP analysis and alizarin red staining indicated that these hollow spheres could clearly promote osteoblast differentiation and mineralization in a dose-dependent manner. Our study suggested that these magnesium silicate hollow spheres could act as promising candidates for enhanced bone regeneration and bone tissue engineering.

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Short-term Administration of Water-soluble Silicon Improves Mineral Density of the Femur and Tibia in Ovariectomized Rats

Cited by 31 publications

References 22 publications

The bone regenerative effects of fucosterol in in vitro and in vivo models of postmenopausal osteoporosis

The bone regenerative effects of fucosterol in in vitro and in vivo models of postmenopausal osteoporosis

Silicon Supplementation Improves the Bone Mineral Density of Calcium-Deficient Ovariectomized Rats by Reducing Bone Resorption

Achieving accelerated osteogenic differentiation via novel magnesium silicate hollow spheres

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