Background: Pre-hospital anaesthesia is a core competency of helicopter emergency medical services (HEMS). Whether physician pre-hospital anaesthesia case volume affects outcomes is unknown in this setting. We aimed to investigate whether physician case volume was associated with differences in mortality or medical management. Methods: We conducted a registry-based cohort study of patients undergoing drug-facilitated intubation by HEMS physician from January 1, 2013 to August 31, 2019. The primary outcome was 30-day mortality, analysed using multivariate logistic regression controlling for patient-dependent variables. Case volume for each patient was determined by the number of pre-hospital anaesthetics the attending physician had managed in the previous 12 months. The explanatory variable was physician case volume grouped by low (0e12), intermediate (13e36), and high (!37) case volume. Secondary outcomes were characteristics of medical management, including the incidence of hypoxaemia and hypotension. Results: In 4818 patients, the physician case volume was 511, 2033, and 2274 patients in low-, intermediate-, and highcase-volume groups, respectively. Higher physician case volume was associated with lower 30-day mortality (odds ratio 0.79 per logarithmic number of cases [95% confidence interval: 0.64e0.98]). High-volume physician providers had shorter on-scene times (median 28 [25the75th percentile: 22e38], compared with intermediate 32 [23e42] and lowest 32 [23e43] case-volume groups; P<0.001) and a higher first-pass success rate for tracheal intubation (98%, compared with 93% and 90%, respectively; P<0.001). The incidence of hypoxaemia and hypotension was similar between groups. Conclusions: Mortality appears to be lower after pre-hospital anaesthesia when delivered by physician providers with higher case volumes.