Short-term effect of pollen exposure on drug consumption for allergic rhinitis and conjunctivitis

Motreff, Yvon; Golliot, Franck; Calleja, Michel; Pape, Annick Le; Fuhrman, C.; Farrera, Isabelle; I, Plaisant

doi:10.1007/s10453-013-9307-1

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…Less dramatic symptoms attracted less attention, although they have a considerable effect on quality of life, production loss and societal costs. They can be measured using proxies such as over-the-counter (OTC) sales of antihistamines (e.g., Fuhrman et al 2007 ; Motreff et al 2014 ; Caillaud et al 2015 ; Sheffield et al 2011 ). These drugs are commonly used for a range of allergic manifestations.…”

Section: Introductionmentioning

confidence: 99%

The relationship between birch pollen, air pollution and weather types and their effect on antihistamine purchase in two Swedish cities

Grundström

Dahl

et al. 2017

Aerobiologia

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Exposure to elevated air pollution levels can aggravate pollen allergy symptoms. The aim of this study was to investigate the relationships between airborne birch (Betula) pollen, urban air pollutants NO2, O3 and PM10 and their effects on antihistamine demand in Gothenburg and Malmö, Sweden, 2006–2012. Further, the influence of large-scale weather pattern on pollen-/pollution-related risk, using Lamb weather types (LWTs), was analysed. Daily LWTs were obtained by comparing the atmospheric pressure over a 16-point grid system over southern Sweden (scale ~3000 km). They include two non-directional types, cyclonic (C) and anticyclonic (A) and eight directional types depending on the wind direction (N, NE, E…). Birch pollen levels were exceptionally high under LWTs E and SE in both cities. Furthermore, LWTs with dry and moderately calm meteorological character (A, NE, E, SE) were associated with strongly elevated air pollution (NO2 and PM10) in Gothenburg. For most weather situations in both cities, simultaneously high birch pollen together with high air pollution had larger over-the-counter (OTC) sales of antihistamines than situations with high birch pollen alone. LWTs NE, E, SE and S had the highest OTC sales in both cities. In Gothenburg, the city with a higher load of both birch pollen and air pollution, the higher OTC sales were especially obvious and indicate an increased effect on allergic symptoms from air pollution. Furthermore, Gothenburg LWTs A, NE, E and SE were associated with high pollen and air pollution levels and thus classified as high-risk weather types. In Malmö, corresponding high-risk LWTs were NE, E, SE and S. Furthermore, occurrence of high pollen and air pollutants as well as OTC sales correlated strongly with vapour pressure deficit and temperature in Gothenburg (much less so in Malmö). This provides evidence that the combination of meteorological properties associated with LWTs can explain high levels of birch pollen and air pollution. Our study shows that LWTs represent a useful tool for integrated daily air quality forecasting/warning.

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Section: Introductionmentioning

confidence: 99%

The relationship between birch pollen, air pollution and weather types and their effect on antihistamine purchase in two Swedish cities

Grundström

Dahl

et al. 2017

Aerobiologia

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“…In general, studies emphasize the effects of pollen on drug sales. () Motreff et al investigated the short‐term relationship between pollen exposure and allergic rhinitis and conjunctivitis in urban areas in the south of France. This research was performed by studying drug deliveries, which showed a statistically significant increase of an interquartile with a relative risk of 1.09 (95% CI, 1.06‐1.13) for Cupressaceae pollen concentrations in Montpellier.…”

Section: Discussionmentioning

confidence: 99%

“…The consumption of medication, especially over‐the‐counter (OTC) drugs, may reflect a lesser degree of severity in morbidity. However, relatively few studies have used this response variable as the main variable, and most of those which have done so() used daily medical prescriptions or refundable drugs supplied to patients affiliated to the social security system/medical insurance, thereby limiting the results to severe or chronic cases within the framework of drug consumption.…”

Section: Introductionmentioning

confidence: 99%

Short‐term effects of heat and cold on respiratory drug use. A time‐series epidemiological study in A Coruña, Spain

Royé

Figueiras

Taracido

2018

Pharmacoepidemiology and Drug

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The consumption of medication, especially over-the-counter drugs, can reflect environmental exposure with a lesser degree of severity in terms of morbidity. The non-linear effects of maximum and minimum apparent temperature on respiratory drug sales in A Coruña from 2006 to 2010 were examined using a distributed lag nonlinear model. In particular, low apparent temperatures proved to be associated with increased sales of respiratory drugs. The strongest consistent risk estimates were found for minimum apparent temperatures in respiratory drug sales with an increase of 33.4% (95% CI, 12.5%-58.0%) when the temperature changed from 2.8°C to -1.4 °C. These findings may serve to guide the planning of public health interventions to predict and manage the health effects of exposure to the thermal environment for lower degrees of morbidity. More precisely, significant increases in the use of measured over-the-counter medication could be used to identify and anticipate influenza outbreaks due to a more sensitive degree of the data source.

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“…Systematic recent reviews and meta‐analyses of the relationships between indoor mould exposure and rhinitis provide sufficient evidence of an association, with an odds ratio generally greater than 1.35. In contrast, information about rhinitis and outdoor moulds is still scarce, although many studies have reported a relationship between allergic rhinitis and pollens . Part of the problem of attributing allergy morbidity to outdoor environmental spore counts is the difficulty in defining a clear‐cut window of spore exposure independent of outdoor pollen allergies.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, information about rhinitis and outdoor moulds is still scarce, [8][9][10] although many studies have reported a relationship between allergic rhinitis and pollens. [11][12][13][14] Part of the problem of attributing allergy morbidity to outdoor environmental spore counts is the difficulty in defining a clear-cut window of spore exposure independent of outdoor pollen allergies. Epidemiological studies have failed to demonstrate a direct relationship between allergy morbidity and outdoor fungal exposure.…”

mentioning

confidence: 99%

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Caillaud

Cheriaux

Martin³

et al. 2018

Clin Experimental Allergy

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Short-term effect of pollen exposure on drug consumption for allergic rhinitis and conjunctivitis

Cited by 15 publications

References 20 publications

The relationship between birch pollen, air pollution and weather types and their effect on antihistamine purchase in two Swedish cities

The relationship between birch pollen, air pollution and weather types and their effect on antihistamine purchase in two Swedish cities

Short‐term effects of heat and cold on respiratory drug use. A time‐series epidemiological study in A Coruña, Spain

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

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