Short-term effects of 3,5,3′–triiodothyronine on the activity of selected enzymes of intermediary metabolism in the liver of the Atlantic hagfish,Myxine glutinosa

Leary, Scot C.; Reddy, K. Rosi; Battersby, BJ; Dugan, Stephen G.; Ballantyne, James S.

doi:10.1002/(sici)1097-010x(19970801)278:5<333::aid-jez7>3.0.co;2-q

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…The exogenous supplementation of hormones at a requisite concentration to a particular stage may fulfil the minimal imbalances due to faulty maternal investment in eggs. Short term exposure of Atlantic hagfish Myxine glutinosa to T3 modulated intermediary metabolism in the liver by increasing the catabolism of lipids to supply the energy requirements of biosynthetic processes (Leary, Reddy, Battersby, Dugan & Ballantyne 1997). In the present study, it was observed that the hormone-treated larvae exhibited more active swimming compared to the control one.…”

Section: Discussionmentioning

confidence: 99%

Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth ofCatla catlalarvae during ontogenic development

2016

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Digestive enzyme profile is a good indicator of the nutritional and health status of the fish. The present investigation aims to evaluate the effect of exogenous bath treatment of hormones, cortisol and triiodothyronine, on the digestive enzyme activities and growth of carp Catla catla (Ham.) during ontogenic development. Catla larvae (4 days old) were given bath treatment with cortisol (hydrocortisone, 0.2 mg L À1 ), 3,5,3 0 -triiodothyronine (T3, 2.5 mg L À1 ) and a combination of cortisol and T3 for 30 min. Digestive enzyme profile was recorded on every third day and was continued for 30 days. Larvae were fed with live food for initial 14 days and then weaned to mix feeding of live food and prepared diet. Significantly (P < 0.05) higher amylase, total protease, trypsin, chymotrypsin, lipase, chitinase and chitinobiase activities were found in the hormone-treated groups compared to the control one during ontogenic development. Among the treated groups, amylase activity was highest in cortisol-treated larvae. Total protease, trypsin, chymotrypsin, lipase, chitinase and chitinobiase activities were significantly (P < 0.05) higher in larvae exposed at combined treatment of cortisol and T3 compared to the other two groups in most sampling days. Average length, weight and specific growth rate of treated larvae were higher compared to the control one. The combined bath treatment of cortisol and triiodothyronine influenced the digestive enzyme activities of catla larvae and thereby enhanced the growth at early developmental stage. This helps the larvae to overcome the problems associated with early developmental stage.

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Section: Discussionmentioning

confidence: 99%

Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth ofCatla catlalarvae during ontogenic development

2016

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Differential effects of thyroxine on metabolic enzymes and other macromolecules in a freshwater teleost

Tripathi

Verma

2003

J. Exp. Zool.

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The effects of thyroxine (T(4)) on citrate synthase (CS), glucose 6-phosphate dehydrogenase (G6-PDH), lactate dehydrogenase (LDH), DNA, RNA, and protein of various tissues were studied to elucidate the hormonal control of metabolism in a freshwater catfish, Clarias batrachus. T(4) did not produce any significant effect on DNA content of the fish. The CS, RNA, and protein contents of brain, liver, and skeletal muscle of the fish exposed to thiourea for 28 days decreased approximately 50-58% as compared to their levels in control individuals. Injection of T(4) to thiourea-exposed fish produced about three-fold increases in CS, RNA, and protein. These macromolecular inductions by T(4) were blocked by actinomycin D or cycloheximide. This suggests T(4)-induced de novo synthesis of macromolecules and stimulation of aerobic capacity. However, the activities of G6-PDH and LDH of brain, liver, and skeletal muscle of the fish exposed to thiourea increased two times that of the activities in control individuals. Administration of T(4) to thiourea-exposed fish reduced LDH and G6-PDH activities by about 64-74%, which reflects T(4)-dependent inhibition in anaerobic power and selective anabolic activities of the HMP pathway. These differential effects of T(4) on some metabolic enzymes and other important macromolecules may be to meet the other T(4)-induced responses in the freshwater catfish.

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Metabolic organization of the spotted ratfish,Hydrolagus colliei (Holocephali: Chimaeriformes): insight into the evolution of energy metabolism in the chondrichthyan fishes

2006

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The metabolic organization of a holocephalan, the spotted ratfish (Hydrolagus colliei), was assessed using measurements of key enzymes of several metabolic pathways in four tissues and plasma concentrations of free amino acids (FAA) and non-esterified fatty acids (NEFA) to ascertain if the Holocephali differ metabolically from the Elasmobranchii since these groups diverged ca. 400 Mya. Activities of carnitine palmitoyl transferase indicate that fatty acid oxidation occurs in liver and kidney but not in heart or white muscle. This result mirrors the well-established absence of lipid oxidation in elasmobranch muscle, and more recent studies showing that elasmobranch kidney possesses a capacity for lipid oxidation. High activities in oxidative tissues of enzymes of ketone body metabolism, including D-beta-hydroxybutyrate dehydrogenase, indicate that, like elasmobranchs, ketone bodies are of central importance in spotted ratfish. Like many carnivorous fishes, enzyme activities demonstrate that amino acids are metabolically important, although the concentration of plasma FAA was relatively low. NEFA concentrations are lower than in teleosts, but higher than in most elasmobranchs and similar to that in some "primitive" ray-finned fishes. NEFA composition is comparable to other marine temperate fishes, including high levels of n-6 and especially n-3 polyunsaturated fatty acids. The metabolic organization of the spotted ratfish is similar to that of elasmobranchs: a reduced capacity for lipid oxidation in muscle, lower plasma NEFA levels, and an emphasis on ketone bodies as oxidative fuel. This metabolic strategy was likely present in the common chondrichthyan ancestor, and may be similar to the ancestral metabolic state of fishes.

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Short-term effects of 3,5,3′–triiodothyronine on the activity of selected enzymes of intermediary metabolism in the liver of the Atlantic hagfish,Myxine glutinosa

Cited by 10 publications

References 21 publications

Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth ofCatla catlalarvae during ontogenic development

Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth ofCatla catlalarvae during ontogenic development

Differential effects of thyroxine on metabolic enzymes and other macromolecules in a freshwater teleost

Metabolic organization of the spotted ratfish,Hydrolagus colliei (Holocephali: Chimaeriformes): insight into the evolution of energy metabolism in the chondrichthyan fishes

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