Short-term effects of desogestrel and ethinyloestradiol on serum proteins in women

Käär, K.; Rhen, Kurt; Tarkkila, Tuukka

doi:10.1080/00365518409083621

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…On day 22, the serum concentrations of SHBG was 18% and the CBG levels 20% higher with 50/50 EE than with 40/30 EE. As 125 pg DG has been shown not to influence the elevation of CBG or SHBG induced by 7 or 14 days of treatment with 50 pg EE [ 17], the results indicate that at these doses the short-term effects of EE on serum binding proteins approach the endpoint. This is corroborated by the effects of combinations of 20 or 30 pg EE with 150 pg DG; on day 21 of one treatment cycle, the SHBG levels differed only by 16% and those of CBG by 12% [ 10], At the end of the cycle of treatment with both formula tions, LH and FSH were profoundly suppressed.…”

Section: Discussionmentioning

confidence: 77%

Serum Concentrations of Ethinylestradiol, 3-Keto-Desogestrel, SHBG, CBG and Gonadotropins during Treatment with a Biphasic Oral Contraceptive Containing Desogestrel

Jung-Hoffmann

Storch²,

Kühl³

1992

Horm Res

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During a cross-over study, the pharmacokinetics of ethinylestradiol (EE) and 3-keto-desogestrel (KDG) were investigated on days 7 and 22 of one cycle of treatment with two biphasic formulations containing 50 µg EE (7 tablets) and 50 µg EE + 125 µg desogestrel (DG) (15 tablets) (50/50 EE) or 40 µg EE + 25 µg DG (7 tablets) and 30 µg EE + 125 µg DG (15 tablets) (40/30 EE). Peak serum levels and areas under the curve of EE increased significantly by 50% between days 7 and 22 of those taking 50/50 EE, while during treatment with 40/30 EE, no difference was found between days 7 and 22. Both formulations caused identical KDG levels on day 22. There were only slight differences in the effects of both preparations on sex-hormone-binding globulin (SHBG; + 150 to +160%) and on corticosteroid-binding globulin (CBG; +130 to +150%) on day 7. On day 22, the changes were more pronounced with 50/50 EE (SHBG, +310%; CBG, +240%) than with 40/30 EE (SHBG, +250%; CBG, + 180%). On day 22 after discontinuation of treatment, the SHBG and CBG levels were still significantly above the control values. Using both formulations, LH and FSH levels were significantly suppressed on day 22, while on day 7 no significant reduction was observed. The rise in the EE levels between days 7 and 22 of 50/50 EE intake and the time course ofthe EE concentrations during treatment with 40/30 EE appear to be due to an inhibition of hepatic metabolism by the contraceptive steroids, as EE is nearly exclusively bound to albumin which does not change.

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Section: Discussionmentioning

confidence: 77%

Serum Concentrations of Ethinylestradiol, 3-Keto-Desogestrel, SHBG, CBG and Gonadotropins during Treatment with a Biphasic Oral Contraceptive Containing Desogestrel

Jung-Hoffmann

Storch²,

Kühl³

1992

Horm Res

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The effect of a biphasic desogestrel-containing oral contraceptive on carbohydrate metabolism and various hormonal parameters

et al. 1993

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Increase in Serum Ceruloplasmin with Aging is not Observed in Type 2 Diabetes.

et al. 2000

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Abstract.Changes of serum ceruloplasmin (Cp) levels have been reported in many conditions including diabetes mellitus (DM), in which the serum Cp levels were increased. In this study, we have examined the influence of aging on serum Cp levels in normal individuals and in individuals with DM. Serum Cp levels were measured in 85 outpatients with type 2 diabetes (type 2 DM group) as well as in 71 healthy individuals (control group). All patients recruited for this study were negative for the glutamic acid decarboxylase (GAD) antibody.The subjects were sub-grouped based on their ages (< 55 and 55 <_ ). The serum Cp levels in the control group increased significantly with aging (r=0.325, p<0.0055), while levels in the type 2 DM group did not (r=0.091, p0.4079).The levels in the type 2 DM group (< 55) were significantly higher than those in the control group (< 55) (p =0.0029), while the Cp levels in the type 2 DM group (55<_) were not different from those in the control group (55<_) (p=0.4187).An age-related increase of serum Cp levels was observed in normal individuals, but this change was not observed in type 2 DM patients since serum Cp levels in type 2 DM patients of all ages were similar to the levels in normal elderly individuals.

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Short-term effects of desogestrel and ethinyloestradiol on serum proteins in women

Cited by 4 publications

References 21 publications

Serum Concentrations of Ethinylestradiol, 3-Keto-Desogestrel, SHBG, CBG and Gonadotropins during Treatment with a Biphasic Oral Contraceptive Containing Desogestrel

Serum Concentrations of Ethinylestradiol, 3-Keto-Desogestrel, SHBG, CBG and Gonadotropins during Treatment with a Biphasic Oral Contraceptive Containing Desogestrel

The effect of a biphasic desogestrel-containing oral contraceptive on carbohydrate metabolism and various hormonal parameters

Increase in Serum Ceruloplasmin with Aging is not Observed in Type 2 Diabetes.

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