Short-term effects of marathon running: no evidence of cardiac dysfunction

Lucı́a, Alejandro; Serratosa, Luis; Saborido, Ana; Pardo, Javier; Boraita, Araceli; Morán, María; Bandrés, Fernando; Megías, Alicia; Chicharro, José López

doi:10.1097/00005768-199910000-00009

Cited by 65 publications

(69 citation statements)

References 21 publications

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“…Goodman et al (2001) reported that 150 min of cycling at $70% _ V O 2max resulted in a 12% increase in HR and a small decline in SV with no decrease in systolic performance. Likewise, Lucia et al (1999) found no change in left ventricular systolic function after 2.5-4 h exercise. It may be that in the current study the exercise duration was not long enough to induce any changes in LV contractile function.…”

Section: Discussionmentioning

confidence: 84%

Cardiac drift during prolonged exercise with echocardiographic evidence of reduced diastolic function of the heart

et al. 2005

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This study examined whether, in 16 male subjects, a continuous increase in heart rate (HR) during 4 h of ergometry cycling relates to cardiac fatigue or cardiomyocyte damage. Serum cardiac troponin T (cTnT) was determined and echocardiographic assessment was carried out prior to and after 2 h of exercise, within 15 min of completing exercise and after 24 h. Left ventricular contractile function (end-systolic blood pressure-volume relationship [SBP/ESV]) and diastolic filling (ratio of early to late peak left ventricular filling velocities [E:A]) were calculated. During exercise HR was 132+/-5 beats min(-1) after 2 h and increased to 141+/-5 beats min(-1) (mean +/- SD; P<0.05), but there was no evidence of altered LV contractile function (SBP/ESV 39.0+/-5.1 mmHg cm(-1) to 36.5+/-5.2 mmHg cm(-1) and SBP/ESV was not correlated to maximal oxygen uptake (r(2)=0.363). In contrast, E:A decreased (1.82+/-0.32 to 1.48+/-0.30; P<0.05) and returned towards baseline after 24 h (1.78+/-0.28), and individual changes were correlated to maximal oxygen uptake (r(2)=0.61; P<0.05). Low levels of cTnT were detected in two subjects after 4 h of exercise that had normalised by 24 h of recovery. During prolonged exercise cardiovascular drift occurred with echocardiographic signs of a reduced diastolic function of the heart, especially in those subjects with a high maximal oxygen uptake.

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Section: Discussionmentioning

confidence: 84%

Cardiac drift during prolonged exercise with echocardiographic evidence of reduced diastolic function of the heart

et al. 2005

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“…The assessment of CPK and CKMB fails to differentiate myocardial injury from the one that occurs in skeletal muscle. Several studies, such as ours, showed no elevation in TnT, even with significant increases in CKMB [24][25][26][27][28] . Others showed an increase of this marker in a heterogeneous group of athletes [29][30][31][32][33] , although it is not known whether this increase really reflects myocardial damage and what the determinants of alteration are in just some athletes.…”

Section: Passaglia Et Al Effects Of Prolonged Physical Exercisementioning

confidence: 82%

“…2013;100(1): [21][22][23][24][25][26][27][28] exercise at high temperatures 18 . It is noteworthy in our study the close inverse association observed between CPK levels and the covered distance.…”

Section: Passaglia Et Al Effects Of Prolonged Physical Exercisementioning

confidence: 99%

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Passaglia¹,

Emed²,

Barberato³

et al. 2013

Arq. Bras. Cardiol.

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“…We were also unable to document the reversibility of the current changes with recovery post-marathon. Although such data exists for transmittal flow (Lucia et al 1999) future research should evaluate this issue with TDI data.…”

Section: Discussionmentioning

confidence: 99%

Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans

George

Oxborough

Forster

et al. 2005

The Journal of Physiology

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We assessed segmental and global left ventricular (LV) diastolic function via tissue-Doppler imaging (TDI) as well as Doppler flow variables before and after a marathon race to extend our knowledge of exercise-induced changes in cardiac function. Twenty-nine subjects (age 18-62 year) volunteered to participate and were assessed pre-and post-race. Measurements of longitudinal plane TDI myocardial diastolic velocities at five sites on the mitral annulus included peak early myocardial tissue velocity (E ), peak late (or atrial) myocardial tissue velocity (A ) and the ratio E /A . Standard pulsed-wave Doppler transmitral and pulmonary vein flow indices were also recorded along with measurements of body mass, heart rate, blood pressures and cardiac troponin T (cTnT), a biomarker of myocyte damage. Pre-to post-race changes in LV diastolic function were analysed by repeated measures ANOVA. Delta scores for LV diastolic function were correlated with each other and alterations in indices of LV loading. Diastolic longitudinal segmental and mean TDI data were altered post-race such that the mean E /A ratio was significantly depressed (1.51 ± 0.34 to 1.16 ± 0.35, P < 0.05). Changes in segmental and global TDI data were not related to an elevated post-race HR, a decreased post-race pre-load or an elevated cTnT. The pulsed wave Doppler ratio of peak early transmitral flow velocity (E)/peak late (or atrial) flow velocity (A) was also significantly reduced post-race (1.75 ± 0.46 to 1.05 ± 0.30, P < 0.05); however, it was significantly correlated with post-race changes in heart rate. The lack of change in E/E from pre-to post-race (3.4 ± 0.8 and 3.3 ± 0.7, respectively) suggests that the depression in diastolic function is likely to be due to altered relaxation of the left ventricle; however, the exact aetiology of this change remains to be determined.

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Short-term effects of marathon running: no evidence of cardiac dysfunction

Abstract: Our findings suggest that marathon running does not adversely affect the hearts of healthy individuals independently from their training status.

Cited by 65 publications

References 21 publications

Cardiac drift during prolonged exercise with echocardiographic evidence of reduced diastolic function of the heart

Cardiac drift during prolonged exercise with echocardiographic evidence of reduced diastolic function of the heart

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in humans

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