Short-Term Effects of Ovomet®, Eggshell Membrane, in Joint Pain. A Double-Blind and Placebo Study

Gil-Quintana, Erena; Fenaux, Marisa; Nuez, Manuel La; Molero, Andrea; Aguirre, Andrés

doi:10.4172/2329-9509.1000211

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…While eggshell calcium is well-known for its ability to prevent bone loss and osteoporosis by increasing bone density, calcium up-take and bone formation ( Rovenský et al, 2003 ), ESM is more often used as supplement in osteoarthritis therapy. In case, a significant improvement of clinical symptoms has been reported in patients suffering from osteoarthritis ( Danesch, 2014 ; Quintana et al, 2018 ). Interestingly, none of these clinical studies have associated the beneficial effect of ESM with an influence of ESM on bone formation.…”

Section: Esm For Bone Density and Bone Formationmentioning

confidence: 98%

Eggshell membrane as promising supplement to maintain bone health: A systematic review

Fladerer,

Grollitsch

2024

Bone Reports

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Section: Esm For Bone Density and Bone Formationmentioning

confidence: 98%

Eggshell membrane as promising supplement to maintain bone health: A systematic review

Fladerer,

Grollitsch

2024

Bone Reports

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“…ESM suppresses the production of IL-1β and TNF-α inflammatory cytokines, subsiding inflammation (Hewlings et al, 2019). The double-blind and placebo study by Gil-Quintana et al (2018) on the effect of daily intake of ESM supplement displayed shortterm effects within the first 3 days. Joint pain was significantly reduced, as was joint dysfunction.…”

Section: Biomedical Applications Of Eggshell Membrane (Esm)mentioning

confidence: 99%

State-of-the-Art of Eggshell Waste in Materials Science: Recent Advances in Catalysis, Pharmaceutical Applications, and Mechanochemistry

Baláž

Болдырева

Rybin

et al. 2021

Front. Bioeng. Biotechnol.

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Eggshell waste is among the most abundant waste materials coming from food processing technologies. Despite the unique properties that both its components (eggshell, ES, and eggshell membrane, ESM) possess, it is very often discarded without further use. This review article aims to summarize the recent reports utilizing eggshell waste for very diverse purposes, stressing the need to use a mechanochemical approach to broaden its applications. The most studied field with regards to the potential use of eggshell waste is catalysis. Upon proper treatment, it can be used for turning waste oils into biodiesel and moreover, the catalytic effect of eggshell-based material in organic synthesis is also very beneficial. In inorganic chemistry, the eggshell membrane is very often used as a templating agent for nanoparticles production. Such composites are suitable for application in photocatalysis. These bionanocomposites are also capable of heavy metal ions reduction and can be also used for the ozonation process. The eggshell and its membrane are applicable in electrochemistry as well. Due to the high protein content and the presence of functional groups on the surface, ESM can be easily converted to a high-performance electrode material. Finally, both ES and ESM are suitable for medical applications, as the former can be used as an inexpensive Ca2+ source for the development of medications, particles for drug delivery, organic matrix/mineral nanocomposites as potential tissue scaffolds, food supplements and the latter for the treatment of joint diseases, in reparative medicine and vascular graft producing. For the majority of the above-mentioned applications, the pretreatment of the eggshell waste is necessary. Among other options, the mechanochemical pretreatment has found an inevitable place. Since the publication of the last review paper devoted to the mechanochemical treatment of eggshell waste, a few new works have appeared, which are reviewed here to underline the sustainable character of the proposed methodology. The mechanochemical treatment of eggshell is capable of producing the nanoscale material which can be further used for bioceramics synthesis, dehalogenation processes, wastewater treatment, preparation of hydrophobic filters, lithium-ion batteries, dental materials, and in the building industry as cement.

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“…Beyond its antioxidant and other health benefits, ESM shows particular promise in improving joint health. Studies have shown ESM to relieve pain associated with OA [ 31 , 32 , 33 , 34 , 35 ]. Ruff et al reported that ESM significantly reduced joint pain and stiffness in postmenopausal female [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection

Yu,

Park,

Son

et al. 2024

Nutrients

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Osteoarthritis (OA) is a chronic degenerative joint disease that causes chronic pain, swelling, stiffness, disability, and significantly reduces the quality of life. Typically, OA is treated using painkillers and non-steroidal anti-inflammatory drugs (NSAIDs). While current pharmacologic treatments are common, their potential side effects have prompted exploration into functional dietary supplements. Recently, eggshell membrane (ESM) has emerged as a potential functional ingredient for joint and connective tissue disorders due to its clinical efficacy in relieving joint pain and stiffness. Despite promising clinical evidence, the effects of ESM on OA progression and its mechanism of action remain poorly understood. This study evaluated the efficacy of Ovomet®, a powdered natural ESM, against joint pain and disease progression in a monosodium iodoacetate (MIA)-induced rodent model of OA in mice and rats. The results demonstrate that ESM significantly alleviates joint pain and attenuates articular cartilage destruction in both mice and rats that received oral supplementation for 5 days prior to OA induction and for 28 days thereafter. Interestingly, ESM significantly inhibited mRNA expression levels of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), as well as inflammatory mediators, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase in the knee joint cartilage at the early stage of OA, within 7 days after OA induction. However, this effect was not observed in the late stage at 28 days after OA induction. ESM further attenuates the induction of protein expression for cartilage-degrading enzymes like matrix metalloproteinase (MMPs) 3 and 13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), in the late-stage. In addition, MIA-induced reduction of the protein expression levels of cartilage components, cartilage oligomeric matrix protein (COMP), aggrecan (ACAN) and collagen type II α-1 chain (COL2α1), and cartilage extracellular matrix (ECM) synthesis promoting transcriptional factor SRY-Box 9 (SOX-9) were increased via ESM treatment in the cartilage tissue. Our findings suggest that Ovomet®, a natural ESM powder, is a promising dietary functional ingredient that can alleviate pain, inflammatory response, and cartilage degradation associated with the progression of OA.

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Short-Term Effects of Ovomet®, Eggshell Membrane, in Joint Pain. A Double-Blind and Placebo Study

Cited by 6 publications

References 8 publications

Eggshell membrane as promising supplement to maintain bone health: A systematic review

Eggshell membrane as promising supplement to maintain bone health: A systematic review

State-of-the-Art of Eggshell Waste in Materials Science: Recent Advances in Catalysis, Pharmaceutical Applications, and Mechanochemistry

Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection

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