Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults

Hassanvand, Mohammad Sadegh; Naddafi, Kazem; Kashani, Homa; Faridi, Sasan; Künzli, Nino; Nabizadeh, Ramin; Momeniha, Fatemeh; Gholampour, Akbar; Arhami, Mohammad; Zare, Ahad; Pourpak, Zahra; Hoseini, Mohammad; Yunesian, Masud

doi:10.1016/j.envpol.2017.02.005

Cited by 97 publications

(72 citation statements)

References 45 publications

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“…Among them, the most concerns are PM 2.5 (particulate matter with diameters less than 2.5 μm) and PM 10 (particulate matter with diameters less than 10 μm). It is suggested that PM 2.5 is more harmful to human health than PM 10 [18]. Moreover, small particle is an essential influential factor to visibility since the mass extinction efficiency of PM 2.5 is 7 times of larger particles [19,20].…”

Section: Introductionmentioning

confidence: 99%

PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

Zhao

Chen

et al. 2019

Advances in Meteorology

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China is suffering severe ambient air pollution in recent decades and particulate matter (PM) has become the major pollutant, especially for PM2.5 and PM10, which have highly raised scholars and policy-makers’ attention in last few years. The existing research has focused on the characteristics of PM2.5 and PM10, respectively, or analyzed the correlation between the two pollutants, while the ratio of PM2.5 to PM10 has been taken less consideration. In this study, daily mean PM2.5 and PM10 mass concentrations in 31 provincial capitals from 2014 to 2016 were used to present the temporal variations and spatial distribution of PM2.5/PM10 ratios among eight economic regions. And then, statistical method and correlation analysis were adopted to investigate the relationship between the ratios and AQI, the rate of change on the ratios, and the impact of meteorological parameters on the ratios. The results indicated that PM2.5/PM10 ratios showed an increasing trend from northwest to southeast due to different economic development and industrial types. The highest values were observed in winter among all regions, and the ratios on weekends were higher than that of on weekdays in most of the regions. Besides, domestic heating in northern China had a significant contribution to the ratios. Moreover, ratios had less changes, and the rate of change was stable in summer. As for air quality, the higher the ratio, the larger the possibility of high AQI so that the air pollution will be more severe. In terms of meteorological factors, the results demonstrated that relative humidity, precipitation, and pressure were the most important factors and had significantly positive impacts, while sunshine duration, temperature, and wind speed had negative effects on the ratios. The findings could identify the pollution sources among PM10 and be helpful for making regulation locally to reduce emission which considers anthropogenic sources and meteorological diffusion simultaneously.

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Section: Introductionmentioning

confidence: 99%

PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

Zhao

Chen

et al. 2019

Advances in Meteorology

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“…Although no clinical examination was planned in this analysis, data extrapolated from other cohort and large studies will explain enormous health effects of Almaty pollution in the city population, given almost 2 million people are affected. Those health effects are widely supported by molecular studies, which all conclude on the inflammation associated with the inhalation of PM [24]. Studies outcomes are more consistent in cardiovascular mortality and allcause mortality, when PM 2.5 is considered as opposed to PM 10 [25].…”

Section: Discussionmentioning

confidence: 92%

Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season

2020

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Background A large fraction of population in Almaty and other Kazakhstan cities is employed in the outdoor jobs and likely exposed to high levels of particulate matter (PM) during the cold season. The magnitude of such occupational exposure remains unknown; therefore, the aim was to quantify the levels of exposure to PM 10 in the outdoor workplaces in Almaty in order to guide future interventions of primary prevention. Methods Outdoor security non-smoking guards (N = 12) wore TSI DustTrack AM520 aerosol monitors with a 10-μm impactor for 8 hours of outdoor shift. Ten samples (k = 10) from each worker were obtained for the cold season (November-March) from various locations across Almaty. Total sampling time was 57600 minutes. We compared normalized time-weighted average (TWA) concentrations for 8-hour shifts within and between workers using analysis of variance (ANOVA) and assessed compliance with environmental exposure limit (EEL) (0.060 mg/m 3) via exceedance (γ) and probability of overexposure (θ). Results PM 10 TWA ranged from 0.050 to 2.075 mg/m 3 with the geometric mean 0.366 and median 0.352 mg/m 3. PM 10 TWA distribution was left-skewed with large variation. The fold-range of within-person variability, containing 95% of the exposure concentration (w R 0.95) was 13, whereas between-person fold-range (b R 0.95) was 3. However, between-person variance exceeded the one within with F-ratio 2.797 (p = 0.003) with statistical power 97% at α = 0.05. Only two of 120 samples had TWA below EEL, yielding γ = 0.995 and θ = 1. Conclusions Outdoor workers in polluted cities like Almaty are exposed to very high levels of PM 10 during the cold season. Urgent action should be taken to regulate such occupational exposure and to raise awareness of workers and employers on hazards associated with it.

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“…Exposure to ambient particle size fractions has become a leading environmental risk factor in global megacities in particular in developing countries. A study in Tehran revealed that short-term exposure to particle size fractions has a positive association with inflammatory biomarkers such as white blood cells, high sensitive C-reactive protein (hsCRP), tumor necrosis factor-soluble receptor-II (sTNF-RII), interleukin-6 (IL-6), and von Willebrand factor in elderly subjects [ 31 ]. Amongst mentioned biomarkers, CRP, IL-6 and sTNF-RII act as predictors of cardiovascular mortality and morbidity [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Study of particle number size distributions at Azadi terminal in Tehran, comparing high-traffic and no traffic area

2018

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Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults

Cited by 97 publications

References 45 publications

PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season

Study of particle number size distributions at Azadi terminal in Tehran, comparing high-traffic and no traffic area

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Short-term effects of particle size fractions on circulating biomarkers of inflammation in a panel of elderly subjects and healthy young adults

Cited by 97 publications

References 45 publications

PM2.5/PM10 Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

PM2.5/PM10 Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season

Study of particle number size distributions at Azadi terminal in Tehran, comparing high-traffic and no traffic area

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PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China

PM_2.5/PM₁₀ Ratios in Eight Economic Regions and Their Relationship with Meteorology in China