Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China

Wu, Shaowei; Yang, Ni; Li, Hongyu; Pan, Lü; Yang, Di; Baccarelli, Andrea A.; Deng, Furong; Chen, Yahong; Shima, Masayuki; Guo, Xinbiao

doi:10.1016/j.envint.2016.05.004

Cited by 150 publications

(84 citation statements)

References 38 publications

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“…Third, formal mediation analysis, as we have carried out for TNF-α, relies on strong and unverifiable assumptions, as we have discussed above. Fourth, correlations between ambient PM 2.5 and other air pollutants from the nearest national air-quality monitoring station, which was about 5 km away from Fudan University, are evidently high (the correlation coefficients during our fieldwork were 0.65 for nitrogen dioxide, 0.67 for carbon monoxide, −0.33 for ozone, 0.65 sulfur dioxide, and 0.87 for PM 10 ), and the causal exposure could be a pollutant that we did not measure (53)(54)(55). Finally, the study subjects were young and healthy nonsmokers, which could limit generalizability of the findings.…”

Section: Discussionmentioning

confidence: 99%

Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution

Wang

Chen

Shi

et al. 2017

American Journal of Epidemiology

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Air pollution may increase cardiovascular and respiratory risk through inflammatory pathways, but evidence for acute effects has been weak and indirect. Between December 2014 and July 2015, we enrolled 36 healthy, nonsmoking college students for a panel study in Shanghai, China, a city with highly variable levels of air pollution. We measured personal exposure to particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM 2.5 ) continuously for 72 hours preceding each of 4 clinical visits that included phlebotomy. We measured 4 inflammation proteins and DNA methylation at nearby regulatory cytosine-phosphate-guanine (CpG) loci. We applied linear mixed-effect models to examine associations over various lag times. When results suggested mediation, we evaluated methylation as mediator. Increased PM 2.5 concentration was positively associated with all 4 inflammation proteins and negatively associated with DNA methylation at regulatory loci for tumor necrosis factor alpha (TNF-α) and soluble intercellular adhesion molecule-1. A 10-μg/m 3 increase in average PM 2.5 during the 24 hours preceding blood draw corresponded to a 4.4% increase in TNF-α and a statistically significant decrease in methylation at one of the two studied candidate CpG loci for TNF-α. Epigenetics may play an important role in mediating effects of PM 2.5 on inflammatory pathways. DNA methylation; fine particulate matter; inflammation; mediation analysis; panel study; personal exposure Abbreviations: CI, confidence interval; CpG, cytosine-phosphate-guanine; CVD, cardiovascular disease; PM, particulate matter; PM 2.5 , particulate matter having an aerodynamic diameter less than or equal to 2.5 μm; RD, respiratory disease; sCD40L, soluble cluster of differentiation 40 (CD40) ligand; sICAM-1, soluble intercellular adhesion molecule-1; TNF-α, tumor necrosis factor alpha.

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Section: Discussionmentioning

confidence: 99%

Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution

Wang

Chen

Shi

et al. 2017

American Journal of Epidemiology

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“…In 2014, the annual average PM2.5 concentration in Beijing was 85.9 μg m −3 . This level is eight times higher than the annual guideline (10 μg m −3 for PM2.5) recommended by the World Health Organization (Wu et al ., ). The remarkable deterioration of air quality in China is caused by rapid industrialization, urbanization and population growth.…”

Section: Introductionmentioning

confidence: 97%

“…PM2.5 is easily inhaled into the respiratory tract and deposited in lung alveoli, where the toxic particles may result in structural damage to the lungs and functional declines. A recent epidemiologic study has shown that short-term exposure to a high ambient air pollution increased airway inflammation biomarker (exhaled hydrogen sulfide) and daily respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD) in Beijing (Wu et al, 2016). In air quality of before (high pollution), during (low pollution) and after (high pollution) the Beijing Olympic periods, the oxidative stress biomarker 8-hydroxy-2-deoxyguanosine in urine and pulmonary inflammation biomarkers (exhaled nitric oxide, H + , nitrite, nitrate) in healthy young adults were associated with changes in air pollutant concentrations (Huang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

et al. 2017

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“…Exposure to particulate matter (PM) pollutants in the atmosphere increases risks for diseases in the respiratory and nervous systems and decreases life expectancy (Allen et al, 2013(Allen et al, , 2014Hunt et al, 2003;Maher et al, 2016;Pope 3rd et al, 2009;Weuve et al, 2012). As one of the major components and pathogenic agents, airborne microorganisms, such as bacteria, are considered to be closely related to air pollution that causes human allergic responses and respiratory diseases (Kim et al, 2018;Wu et al, 2016). Many studies have been carried out on airborne bacteria in environment (Fang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Comparison of culturable antibiotic-resistant bacteria in polluted and non-polluted air in Beijing, China

Mao

Ding

Wang

et al. 2019

Environment International

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Background: Air pollution has been a serious health issue in Beijing for years. Airborne antibiotic-resistant bacteria could be a potential health crisis as reserve of antibiotic resistance transmission in environment. The composition and antibiotic resistance pattern of culturable bacterial community and how these are affected by air pollution remain unclear.Objectives: This study aimed to compare the compositions and antibiotic resistance patterns of culturable bacteria in polluted and non-polluted weather conditions in Beijing. Methods: Air samples were collected indoors and outdoors during polluted and non-polluted weather using sixstage Andersen Samplers. For each isolated bacterium, the 16S ribosomal RNA gene was amplified, sequenced, and blasted against the National Center for Biotechnology Information database Antibiotic resistance was conducted by antimicrobial susceptibility testing. Results: Bacterial concentration in polluted weather was significantly higher than in non-polluted weather, both indoors and outdoors (P < 0.05). Gram-positive bacteria (GPB) were dominant in both weathers but gramnegative bacteria (GNB) were more abundant in polluted weather than non-polluted weather both indoors and outdoors. Multidrug-resistant (MDR) bacteria occupied 23.7% of all bacterial isolates, 22.4% of isolates from polluted weather and 27.8% of isolates from non-polluted weather. Penicillins were resisted by 72.4% and 83.3% of isolates from polluted and non-polluted weather, respectively. Conclusions: The bacterial concentration was significantly higher in polluted weather, compared to non-polluted weather. Polluted weather is correlated with changes in the bacterial composition in the air, with a greater abundance of GNB. Penicillins was resisted by over 70% of bacterial isolates. The abundance of MDR bacteria suggested potential risks for human health.

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Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China

Cited by 150 publications

References 38 publications

Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution

Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution

PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

Comparison of culturable antibiotic-resistant bacteria in polluted and non-polluted air in Beijing, China

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