Short-term in vivo evaluation of zinc-containing calcium phosphate using a normalized procedure

Calasans-Maia, Mônica Diuana; Calasans-Maia, José de Albuquerque; Santos, Silvia Albuquerque; Mavropoulos, Elena; Farina, Marcos; Lima, I.; Lopes, Ricardo Tadeu; Rossi, Alexandre M.; Granjeiro, José Mauro

doi:10.1016/j.msec.2014.04.054

Cited by 26 publications

(32 citation statements)

References 27 publications

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“…The XRF spectrometer was operated at 40 kV and 50 mA with a Ge (111) crystal, a collimator of 550 μm and a flow detector for the KV lines of calcium, strontium, potassium and zinc. 4 …”

Section: X-ray Microfluorescence With Synchrotron Radiationmentioning

confidence: 99%

“…Various methods have been applied for the restoration of bone defects and preservation of bone morphology, 1,2 and several techniques for bone restoration have been developed and improved in recent years, including bone block grafts, guided bone regeneration, distraction osteogenesis, and the use of new biomaterials and growth factors. 3,4,5 Although autogenous bone…”

Section: Introductionmentioning

confidence: 99%

“…These results are consistent with those of previous studies on the repair of critical-and non-critical-sized defects, with bone formation from the periphery to the center of the defect. 4,13 Moreover, evaluation of the tissue responses to different biomaterials implanted in sheep tibias showed that they exhibited granulation reactions to the biomaterials that were confined to the implant sites, characterized by chronic inflammation. It is well known that anorganic xenografts and …”

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confidence: 99%

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Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

et al. 2016

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The aim of this study is to evaluate the biocompatibility and osteoconductivity in surgical defects of sheep tibias filled with 1% strontium-containing nanostructured hydroxyapatite microspheres (SrHA), stoichiometric hydroxyapatite without strontium microspheres (HA), or blood clots. Santa Ines sheep were subjected to three perforations on the medial side of the left tibia. The biomaterials were characterized by X-ray Diffraction (XRD) and Fourier Transform Infrared (FTIR) before implantation and by X-Ray Microfluorescence (µFRX) and Scanning Electron Microscopy (SEM) after sheep tibias implantation. Surgical defects were filled with blood clots (control), SrHA (Group 1) or HA (Group 2). After 30 days, 5-µm bone blocks were obtained for histological evaluation, and the blocks obtained from 1 animal were embedded in methylmethacrylate for undecalcified sections. Mononuclear inflammatory infiltrate remained mild in all experimental groups. Giant cells were observed surrounding biomaterials particles of both groups and areas of bone formation were detected in close contact with biomaterials. All groups showed newly formed bone from the periphery to the center of the defects, which the control, HA and SrHA presented 36.4% (± 21.8), 31.2% (± 14.7) and 26.2% (± 12.9) of newly formed bone density, respectively, not presenting statistical differences. In addition, the connective tissue density did not show any significant between groups. The SrHA showing a higher volume density of biomaterial (51.2 ± 14.1) present in the defect compared to HA (32.6 ± 8.5) after 30 days (p = 0.03). Microspheres containing 1% SrHA or HA can be considered biocompatible, have osteoconductive properties and may be useful biomaterials for clinical applications.

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“…The XRF spectrometer was operated at 40 kV and 50 mA with a Ge (111) crystal, a collimator of 550 μm and a flow detector for the KV lines of calcium, strontium, potassium and zinc. 4 …”

Section: X-ray Microfluorescence With Synchrotron Radiationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

et al. 2016

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“…Zn 2 þ doped HAs were synthesized to investigate their antimicrobial characteristics, microstructure, sintering behavior, and in-vivo responses [17][18][19][20][21]. It was shown that Zn incorporation into implants promotes bone formation around the implant and decreases the inflammatory response [16,22].…”

Section: Introductionmentioning

confidence: 99%

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Uysal

Severcan

Tezcaner

et al. 2014

Progress in Natural Science: Materials International

108

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Hydroxyapatite (HA) co-doped with Zn 2 þ and F À ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn 2 þ and F À ions incorporation into HA structure. Co-doping of Zn 2 þ and F À ions decreased unit cell volume of HA and decreased grain sizes. Zn 2 þ or 5 mol% F À addition into HA significantly improved its density. Microhardness was increased with Zn 2 þ addition and further increase was detected with F À co-doping. Zn 2 þ and F À co-doped samples had higher fracture toughness than pure HA. Zn 2 þ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F À addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.

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“…Bone defects owing to trauma, disease, or congenital defect, etc., are a worldwide problem [1]. Autografts and allografts have been widely used to repair the bone defects in clinic, but they are faced with disadvantages such as donor site morbidity, limited source, and disease transmission, etc.…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

Zhang

Yang

et al. 2015

Materials Science and Engineering: C

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Short-term in vivo evaluation of zinc-containing calcium phosphate using a normalized procedure

Cited by 26 publications

References 27 publications

Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

Histomorphometric evaluation of strontium-containing nanostructured hydroxyapatite as bone substitute in sheep

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

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