Short-term oral administration of several manganese compounds in mice: Physiological and behavioral alterations caused by different forms of manganese

Komura, Junko; Sakamoto, Michiko

doi:10.1007/bf01689739

Cited by 22 publications

(8 citation statements)

References 11 publications

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“…Numerous studies conducted in rodents provide at least partial support for this hypothesis. Rodent studies have demonstrated that depletion of striatal dopamine and loss of nigro-striatal dopaminergic neurons occur following highdose manganese exposure [Chandra et al, 1978;Gianutsos and Murray, 1982;Komura and Sakamoto, 1991;Bonilla et al, 1994;Pappas et al, 1997]. Studies conducted in nonhuman primates result in similar findings.…”

supporting

confidence: 51%

Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation

Struve

McManus

Wong

et al. 2007

American J Industrial Med

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supporting

confidence: 51%

Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation

Struve

McManus

Wong

et al. 2007

American J Industrial Med

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“…The supernatant following centrifugation at 13,000 ×g for 20 minutes was processed; the supernatant contained AChE that was used for enzyme assay [18]. AChE (EC 3.1.1.7) activity was determined by the method of Komura [19], which is based on the formation of the yellow 5-thio-2-nitrobenzoate anion produced in the reaction between 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) and thiocholine, after the AChE-mediated hydrolysis of ATCh. Samples were weighed (100 mg of the brain homogenate) and 1.8 mL of 28 mM buffer sodium phosphate dibasic anhydrous/sodium phosphate monobasic pH 7.8 and 0.2 mL of 5% Triton X100 were added to each tube.…”

Section: Methodsmentioning

confidence: 99%

The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains

Babadi

Sadeghi

Shirani

et al. 2014

Journal of Toxicology

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Manganese (Mn) is a naturally occurring element and an essential nutrient for humans and animals. However, exposure to high levels of Mn may cause neurotoxic effects. Accumulation of manganese damages central nervous system and causes Parkinson's disease-like syndrome called manganism. Mn neurotoxicity has been suggested to involve an imbalance between the DAergic and cholinergic systems. The pathological mechanisms associated with Mn neurotoxicity are poorly understood, but several reports have established it is mediated by changing of AChE activity that resulted in oxidative stress. Therefore we focused the effect of Mn in AChE activity in the rat's brain by MnCl2 injection intraperitoneally and analyzed their brains after time intervals. This study used different acute doses in short time course and different chronic doses at different exposing time to investigate which of them (exposing dose or time) is more important in Mn toxic effect. Results showed toxic effect of Mn is highly dose dependent and AChE activity in presence of chronic dose in 8 weeks reaches acute dose in only 2 days.

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“…In principle, oral applications are also possible, but less well controlled as absorption from the gastrointestinal tract can be influenced by many factors. These include the chemical form (79), the presence of other minerals and dietary constituents (33,80,81), and the age of the animal (82)(83)(84). Furthermore, adaptive changes to high dietary manganese intake lead to reduced absorption and enhanced hepatic (biliary) or pancreatic excretion of manganese (19,(85)(86)(87)(88).…”

Section: Routes Of Manganese Administrationmentioning

confidence: 97%

Manganese-Enhanced Magnetic Resonance Imaging

Boretius

Frahm

2011

Methods in Molecular Biology

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Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T (1) relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by MRI with the biological information gathered by tissue-specific or functionally induced accumulations of manganese. After in vivo administration, manganese ions may enter cells via voltage-gated calcium channels. In the nervous system, manganese ions are actively transported along the axon. Based on these properties, MEMRI is increasingly used to delineate neuroanatomical structures, assess differences in functional brain activity, and unravel neuronal connectivities in both healthy animals and models of neurological disorders. Because of the cellular toxicity of manganese, a major challenge for a successful MEMRI study is to achieve the lowest possible dose for a particular biological question. Moreover, the interpretation of MEMRI findings requires a profound knowledge of the behavior of manganese in complex organ systems under physiological and pathological conditions. Starting with an overview of manganese pharmacokinetics and mechanisms of toxicity, this chapter covers experimental methods and protocols for applications in neuroscience.

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Short-term oral administration of several manganese compounds in mice: Physiological and behavioral alterations caused by different forms of manganese

Cited by 22 publications

References 11 publications

Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation

Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation

The Toxic Effect of Manganese on the Acetylcholinesterase Activity in Rat Brains

Manganese-Enhanced Magnetic Resonance Imaging

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