Short‐term outcome after total elbow arthroplasty in dogs with severe, naturally occurring osteoarthritis

Conzemius, Michael G.; Aper, Rhonda L.; L, Corti

doi:10.1111/j.1532-950x.2003.00545.x

Cited by 48 publications

(46 citation statements)

References 8 publications

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“…The adult canine animal model was selected based on the availability of vast amounts of historical data; its clinical relevance with respect to anatomy, function, and clinical disorders in veterinary patients; and the ability to readily perform surgical treatments such as arthroplasty, autologous chondrocyte transplantation, and osteochondral grafting, as well as postoperative management protocols, including bandaging, braces, and physical rehabilitation modalities. [25][26][27][28][29] These aspects of the canine model are important for future validation and comparison of tissue engineering to the accepted clinical treatments. In addition, whether from allograft or from autograft sources, the cells that will likely be used for human treatment will probably be derived from older adults.…”

Section: Introductionmentioning

confidence: 99%

Passaged Adult Chondrocytes Can Form Engineered Cartilage with Functional Mechanical Properties: A Canine Model

Lima

Bian

et al. 2010

Tissue Engineering Part A

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It was hypothesized that previously optimized serum-free culture conditions for juvenile bovine chondrocytes could be adapted to generate engineered cartilage with physiologic mechanical properties in a preclinical, adult canine model. Primary or passaged (using growth factors) adult chondrocytes from three adult dogs were encapsulated in agarose, and cultured in serum-free media with transforming growth factor-beta3. After 28 days in culture, engineered cartilage formed by primary chondrocytes exhibited only small increases in glycosaminoglycan content. However, all passaged chondrocytes on day 28 elaborated a cartilage matrix with compressive properties and glycosaminoglycan content in the range of native adult canine cartilage values. A preliminary biocompatibility study utilizing chondral and osteochondral constructs showed no gross or histological signs of rejection, with all implanted constructs showing excellent integration with surrounding cartilage and subchondral bone. This study demonstrates that adult canine chondrocytes can form a mechanically functional, biocompatible engineered cartilage tissue under optimized culture conditions. The encouraging findings of this work highlight the potential for tissue engineering strategies using adult chondrocytes in the clinical treatment of cartilage defects.

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Section: Introductionmentioning

confidence: 99%

Passaged Adult Chondrocytes Can Form Engineered Cartilage with Functional Mechanical Properties: A Canine Model

Lima

Bian

et al. 2010

Tissue Engineering Part A

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“…A force platform can provide an objective measure of ground reaction force on limbs of dogs (Jevens and others 1993, Budsberg and others 1995) and has been proposed as an external standard measure in canine lameness (Hudson and others 2004) for the evaluation of criterion validity. The peak vertical force (PVF) on an index limb has often been the primary outcome measure used in laboratory and clinical studies in dogs to provide efficacy data on medical (Vasseur and others 1995, Budsberg and others 1999, Innes and others 2003), nutritional and surgical (Conzemius and others 2003, Conzemius and others 2005) interventions. However, while the force platform certainly provides reliable and objective data, such equipment is often confined to clinical research institutions.…”

Section: Introductionmentioning

confidence: 99%

Validation of a client‐based clinical metrology instrument for the evaluation of canine elbow osteoarthritis

Hercock

Pinchbeck

Giejda

et al. 2009

J of Small Animal Practice

118

145

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“…Although an owner's detailed assessment of chronic pain is routinely relied on in clinical decision making for the management of osteoarthritis pain, it is not used routinely as an outcome measure in clinical trials designed to evaluate interventions for osteoarthritis pain. [1][2][3][4][5][6][7][8][9] This apparently is attributable to the subjective nature of an owner's assessment; however, sound methods exist for the development and application of tools to assess and quantify peoples' perception of subjective states. [10][11][12] Although pain behaviors are the result of a complex set of inputs and qualities unique to each animal, appropriate, established principles of questionnaire development [10][11][12][13][14][15][16][17][18] can be used to develop valid and reliable behavior-based assessment instruments for owner appraisal of chronic pain in dogs.…”

mentioning

confidence: 99%

Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis

Brown¹,

Boston²,

Coyne³

et al. 2007

ajvr

194

207

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Objective-To develop and psychometrically test an owner self-administered questionnaire designed to assess severity and impact of chronic pain in dogs with osteoarthritis.Sample Population-70 owners of dogs with osteoarthritis and 50 owners of clinically normal dogs.Procedures-Standard methods for the stepwise development and testing of instruments designed to assess subjective states were used. Items were generated through focus groups and an expert panel. Items were tested for readability and ambiguity, and poorly performing items were removed. The reduced set of items was subjected to factor analysis, reliability testing, and validity testing.Results-Severity of pain and interference with function were 2 factors identified and named on the basis of the items contained in them. Cronbach's α was 0.93 and 0.89, respectively, suggesting that the items in each factor could be assessed as a group to compute factor scores (ie, severity score and interference score). The test-retest analysis revealed κ values of 0.75 for the severity score and 0.81 for the interference score. Scores correlated moderately well (r = 0.51 and 0.50, respectively) with the overall quality-of-life (QOL) question, such that as severity and interference scores increased, QOL decreased. Clinically normal dogs had significantly lower severity and interference scores than dogs with osteoarthritis. Conclusions and Clinical Relevance-A psychometrically sound instrument was developed.Responsiveness testing must be conducted to determine whether the questionnaire will be useful in reliably obtaining quantifiable assessments from owners regarding the severity and impact of chronic pain and its treatment on dogs with osteoarthritis.It is crucial to have quantitative measures of chronic pain that are valid and reliable in clinical patients to enable development and testing of interventions (such as drugs or surgical procedures) designed to reduce such pain. In the past, studies designed to test the efficacy of interventions intended to decrease chronic pain in dogs with osteoarthritis have relied heavily on a veterinarian's assessment of lameness supported by values generated through gait analysis by use of a force plate. When collected properly, data on gait analysis offer an objective measure that can be reliably monitored over time; however, it can be extremely time consuming, requires specialized equipment, and relies on relatively strict inclusion criteria. In addition, these measures only evaluate an animal at 1 specific point in NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript time, and weight bearing on an affected limb is only 1 part of the much larger picture of chronic pain in dogs with osteoarthritis. [1][2][3][4][5] When an owner brings a dog to a veterinarian with a concern that the dog has signs of a chronic painful condition, they report a number of behaviors that they attribute to the painful condition (eg, no longer climbs stairs or jumps onto the bed). In monitoring the progression of the dog's cond...

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Short‐term outcome after total elbow arthroplasty in dogs with severe, naturally occurring osteoarthritis

Abstract: Based on 1-year data, TEA can be successfully performed in dogs and should be considered as a treatment alternative for adult dogs with lameness from severe OA of the elbow joint.

Cited by 48 publications

References 8 publications

Passaged Adult Chondrocytes Can Form Engineered Cartilage with Functional Mechanical Properties: A Canine Model

Passaged Adult Chondrocytes Can Form Engineered Cartilage with Functional Mechanical Properties: A Canine Model

Validation of a client‐based clinical metrology instrument for the evaluation of canine elbow osteoarthritis

Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis

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