Short-term outcomes of laparoscopic lateral pelvic node dissection for advanced lower rectal cancer

Tokuhara, Katsuji; Hishikawa, Hidehiko; Yoshida, Terufumi; Ueyama, Yosuke; Yoshioka, Kazuhiko; Sekimoto, Mitsugu

doi:10.1007/s00464-020-07534-3

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…According to these findings, LLND is recommended for Japanese LARC patients in the Japanese Society for Cancer of the Colon and Rectum Guidelines 2019 for the Treatment of Colorectal Cancer [27]. In the present study, we performed laparoscopic LLND for all patients, except in one patient with chronic heart failure [28]. In the present study, the median follow-up period was short (40 months), and there was only one patient who developed local recurrence in the pelvic floor.…”

Section: Discussionmentioning

confidence: 68%

Feasibility and Efficacy of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer

Tokuhara

Matsui

Ueyama

et al. 2022

J Anus Rectum Colon

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Objectives: This retrospective study explored the feasibility of neoadjuvant chemotherapy (NAC) without radiotherapy in patients with locally advanced rectal cancer (LARC). Methods: Patients with clinical stage of T3-T4 and/or N-positive LARC patients were included. We retrospectively analyzed patients' NAC-related and perioperative outcomes. Results:The study enrolled 30 patients. mFOLFOX6 or SOX plus cetuximab was administered to 12 patients with the wild-type RAS gene and FOLFOXIRI or SOXIRI to 18 patients with mutant-type RAS. The NAC completion rate was 90.0%. All patients underwent total mesorectal excision, and 29 patients underwent combined bilateral lateral lymph node dissection. The R0 operation rate was 90.0%. Although the postoperative complication rate was 40%, no complications were associated with NAC. The response rate of NAC and the proportion of histological anti-tumor effect grade !2 were 56.7% and 46.7%, respectively. Conclusions: NAC was considered to be a safe, feasible treatment option for LARC.

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Section: Discussionmentioning

confidence: 68%

Feasibility and Efficacy of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer

Tokuhara

Matsui

Ueyama

et al. 2022

J Anus Rectum Colon

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“…There were no significant differences between the 2 groups regarding the residual tumor status, pathological T category, pathological N category, pathological stage, or total number of metastatic positive lateral pelvic LNs. The POHS in the NIR group was significantly shorter than that in the non-NIR group (14 days [10][11][12][13][14][15][16][17][18][19] vs. 17 days [13][14][15][16][17][18][19][20][21]; p = 0.03); however, the total postoperative complication rate (within 30 days after surgery, CD grade ≥II) and postoperative adjuvant chemotherapy rate did not differ to a statistically significant extent.…”

Section: Resultsmentioning

confidence: 76%

“…All cases involving combined resection of adjacent organs were performed laparoscopically. The total number of harvested lateral pelvic LNs in the NIR group was significantly higher than that in the non-NIR group (14 [10][11][12][13][14][15][16][17][18] vs. 9 [5][6][7][8][9][10][11]; p < 0.001). There were no significant differences between the 2 groups regarding the residual tumor status, pathological T category, pathological N category, pathological stage, or total number of metastatic positive lateral pelvic LNs.…”

Section: Resultsmentioning

confidence: 82%

“…11,12 In recent years, the number of reports on laparoscopic LPLND has been increasing, and findings have reported it to be safe and technically feasible. 11,13,14 However, laparoscopic LPLND is one of the most complicated surgical procedures from the viewpoint of anatomical complexity of the lateral region in the pelvis and autonomic nerve preservation. [15][16][17] Thus far, details on the lymphatic flow in the lateral region of the pelvis have not been completely clear and the quality of LPLND has been a problem for colorectal surgeons.…”

Section: Principales Resultados Medidasmentioning

confidence: 99%

“…11,12 In recent years, the number of reports on laparoscopic LPLND has been increasing, and findings have reported it to be safe and technically feasible. 11,13,14…”

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confidence: 99%

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Near-Infrared Imaging Using Indocyanine Green for Laparoscopic Lateral Pelvic Lymph Node Dissection for Clinical Stage II/III Middle-Lower Rectal Cancer: A Propensity Score-Matched Cohort Study

Ohya

Watanabe

Suwa

et al. 2022

Diseases of the Colon &Amp; Rectum

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BACKGROUND:The examination of the efficacy of nearinfrared imaging using indocyanine green in laparoscopic lateral pelvic lymph node dissection remains insufficient. OBJECTIVE:The aim of this study was to examine whether near-infrared imaging contributed to an increase in the total number of harvested lateral pelvic lymph nodes in laparoscopic lateral pelvic lymph node dissection.DESIGN: This was a retrospective, multi-institutional study with propensity score matching. SETTINGS:We conducted this study within the framework of the Yokohama Clinical Oncology Group in Japan. PATIENTS:The study population included consecutive patients with middle-low rectal cancer (clinical stage II to III) who underwent laparoscopic lateral pelvic lymph node dissection between January 2013 and February 2018. MAIN OUTCOME MEASURES:The total number of harvested lateral pelvic lymph nodes was compared in laparoscopic lateral pelvic lymph node dissection with and without near-infrared imaging.RESULTS: A total of 172 eligible patients were included; 84 of these patients underwent laparoscopic surgery with near-infrared imaging. After propensity score matching, 58 patients were matched in each of the near-infrared and the non-near-infrared groups. The operation time in the near-infrared group was significantly longer than that in the non-near-infrared group (426 vs 369 min), and the amount of intraoperative blood loss in the near-infrared group was significantly smaller than that in the non-near-infrared group (13 vs 110 mL). The total number of harvested lateral pelvic lymph nodes in the near-infrared group was significantly higher than that in the non-near-infrared group (14 vs 9). There were no significant differences in the postoperative complication rates of the 2 groups. LIMITATIONS:The limitations of the present study include its retrospective design. CONCLUSIONS:This study revealed that laparoscopic lateral pelvic lymph node dissection combined with near-infrared imaging could increase the total number of harvested lateral pelvic lymph nodes without impairing functional preservation. See Video Abstract at http:// links.lww.com/DCR/B800. This study was registered with the Japanese Clinical Trials Registry as UMIN000041372 (http://www.umin.ac.jp/ctr/ index.htm).

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Long-term outcomes of indocyanine green fluorescence imaging-guided laparoscopic lateral pelvic lymph node dissection for clinical stage II/III middle-lower rectal cancer: a propensity score-matched cohort study

et al. 2023

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Short-term outcomes of laparoscopic lateral pelvic node dissection for advanced lower rectal cancer

Cited by 9 publications

References 15 publications

Feasibility and Efficacy of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer

Feasibility and Efficacy of Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer

Near-Infrared Imaging Using Indocyanine Green for Laparoscopic Lateral Pelvic Lymph Node Dissection for Clinical Stage II/III Middle-Lower Rectal Cancer: A Propensity Score-Matched Cohort Study

Long-term outcomes of indocyanine green fluorescence imaging-guided laparoscopic lateral pelvic lymph node dissection for clinical stage II/III middle-lower rectal cancer: a propensity score-matched cohort study

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