Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease

Abstract

Our results provide evidence that QoL improvement after STN-DBS depends on preoperative NMS characteristics. These findings are important in the advising and selection of individuals for DBS therapy. Future studies investigating motor and non-motor PD clusters may enable stratifying QoL outcomes and help predict patients' individual prospects of benefiting from DBS.

Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease

“…However, we were interested in a pragmatic assessment of a wide range of sleep-wake disturbances including complex symptoms, such as nocturia, nocturnal psychosis, motor state-related sleep symptoms, and sleep refreshment, which cannot be captured by polysomnography. Due to the design of our database as a prospective, observational study, motor assessments were recorded in ON states (MedON/StimON) [15]. Although the current study did not find a relationship/correlation between change in motor exam and change in sleep, this is still an important potential contributor to the improvement in sleep and the relationship may have been masked because participants were only evaluated in ON states.…”

Beneficial effects of bilateral subthalamic stimulation on alexithymia in Parkinson's disease

“…In all scales, higher scores represent more severe impairment. Other non‐motor aspects. The Parkinson's Disease Sleep Scale‐1 (PDSS), ranging from 0 to 150 (lower scores represent more severe impairment) , Non‐Motor Symptoms Questionnaire (NMSQ), ranging from 0 to 30 , and Non‐Motor Symptom Scale (NMSS), ranging from 0 to 360, which surveys nine different domains of non‐motor symptoms (higher scores represent more severe impairment for both) were used. Motor disorder. The Unified Parkinson's Disease Rating Scale (UPDRS)‐II, ‐III and ‐IV were used to assess activities of daily living, motor examination and motor complications.…”

“…Sleep Scale-1 (PDSS), ranging from 0 to 150 (lower scores represent more severe impairment) [29], Non-Motor Symptoms Questionnaire (NMSQ), ranging from 0 to 30 [30], and Non-Motor Symptom Scale (NMSS), ranging from 0 to 360, which surveys nine different domains of non-motor symptoms (higher scores represent more severe impairment for both) [31][32][33] were used. 4) Motor disorder.…”

An update on adaptive deep brain stimulation in Parkinson's disease

“…We believe that subjective experience of motor symptoms could improve the interpretation of objective motor symptom monitoring. Nonmotor symptoms are important for quality‐of‐life scores and might predict overall DBS outcomes . Electronic health (eHealth) and mobile health (mHealth) applications and telemonitoring concepts have been recently integrated into PD care and contain the aforementioned missing features .…”

“…Nonmotor symptoms are important for quality-of-life scores and might predict overall DBS outcomes. 65 Electronic health (eHealth) and mobile health (mHealth) applications and telemonitoring concepts have been recently integrated into PD care and contain the aforementioned missing features. [66][67][68][69] Most of these developments are achieved in order to improve PD care and ensure its accessibility and cost-effectiveness.…”