Short-term regulation of glycolysis by vasoactive intestinal peptide in epithelial cells isolated from rat small intestine

Rossi, Irma; Monge, Luis; Feliu, Jaume Cruz i

doi:10.1042/bj2620397

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…However, although the SCN is the major production site of VIP within the hypothalamus, the results of the VIP‐null mice provide no evidence for the involvement of SCN VIP in glucose metabolism because VIP has been shown to have clear effects on glucose metabolism both at central and peripheral levels. In the periphery, VIP may affect glucose metabolism at the level of the pancreas , the gastrointestinal tract and the liver . After central administration, VIP has been shown to decrease plasma glucose levels in 6‐day‐old chickens but to increase it in adult male Wistar rats .…”

Section: Discussionmentioning

confidence: 99%

Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production

Foppen

Tan

Ackermans

et al. 2016

J Neuroendocrinology

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Defective control of endogenous glucose production is an important factor responsible for hyperglycaemia in the diabetic individual. During the past decade, progressively more evidence has appeared indicating a strong and potentially causal relationship between disturbances of the circadian system and defects of metabolic regulation, including glucose metabolism. The detrimental effects of disturbed circadian rhythms may have their origin in disturbances of the molecular clock mechanisms in peripheral organs, such as the pancreas and liver, or in the central brain clock in the hypothalamic suprachiasmatic nuclei (SCN). To assess the role of SCN output per se on glucose metabolism, we investigated (i) the effect of several SCN neurotransmitters on endogenous glucose production and (ii) the effect of SCN neuronal activity on hepatic and systemic insulin sensitivity. We show that silencing of SCN neuronal activity results in decreased hepatic insulin sensitivity and increased peripheral insulin sensitivity. Furthermore, both oxytocin neurones in the paraventricular nucleus of the hypothalamus (PVN) and orexin neurones in the lateral hypothalamus may be important targets for the SCN control of glucose metabolism. These data further highlight the role of the central clock in the pathophysiology of insulin resistance.

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