Short-term repeatability of resting myocardial blood flow measurements using rubidium-82 PET imaging

Abstract

Absolute MBF can be measured with good repeatability using FlowQuant analysis of (82)Rb PET scans with a 6-minute scan time, iterative reconstruction, dual SOC, RPP-adjustment, and an image-derived input function in the left atrium cavity.

Myocardial flow reserve (MFR) with positron emission tomography (PET)/computed tomography (CT): clinical impact in diagnosis and prognosis

“…Its accuracy has been extensively validated in experimental animals and humans, and the reproducibility of this technique is well established (15)(16)(17). However, multiple factors have limited widespread clinical application including availability of scanners, increased cost, and reimbursement issues.…”

How to reconstruct dynamic cardiac PET data?

“…The improved overall repeatability of quantitative MBF measurements has been demonstrated with iterative reconstruction. 12 …”

Accurate myocardial blood flow measurements: Quality from start to finish is key to success

“…For example, 1TCM applications require the blood pool ROI be placed within the left ventricle. 7 In contrast, most SRM applications require the blood pool ROI be placed in the left atrium. 1,3 The location of these ROIs is crucial in obtaining accurate blood flow measurement, and technologists must be trained on appropriate processing techniques.…”