Short-Term Tissue Response of Lapine Carotid Artery Microanastomoses to BioGlue®

Abstract

The results of this short-term study show that the rabbit is an adequate as well as a sensitive model for the study of microanastomoses by glueing. Marked inflammatory reactions developed which may lead to vascular sclerosis or stenosis, and long-term studies are necessary to elucidate this problem further.

The effect of bovine serum albumin-glutaraldehyde and polyethylene glycol polymer on neointimal hyperplasia in rabbit carotid artery anastomosis

“…48 In our study, cell necrosis was not observed in the BSA-glutaraldehyde group, but inflammation was observed. Sutureless anastomosis using BSA-glutaraldehyde in the rabbit carotid artery and sutured anastomosis were compared by Schiller et al 49 and they found no significant difference in terms of intra-luminal thrombosis. But, they showed that there was more inflammatory cell in the sutureless anastomosis group.…”

Sutureless anastomoses of rabbit carotid arteries with BioGlue

“…Wippermann and coworkers 3 found severe inflammatory reactions associated with the use of BioGlue in porcine coronary artery surgery when they compared 3 different types of adhesives. The short-term study of our group 4 identified a marked inflammatory response as early as 2 days after application of the glue to rabbit carotid arteries; stenoses, thrombi, and pseudoaneurysms were also noted. The present study investigated the morphologic and histologic changes of the rabbit carotid artery 60 days after a completely sutureless anastomosis with BioGlue.…”

Histological effects of fibrin glue and synthetic tissue glues on the spinal cord: are they safe to use?

“…However, rarely in some specimens it did show a minor foreign body reaction but neither fibrosis or multinucleated giant cells were seen. 12 However, other cardiac, thoracic and vascular studies have reported inflammatory responses, [20][21][22] fibrosis, [21][22][23] tissue necrosis 20 and foreign body reaction 24 with the use of BioGlue®. Other clinical studies have suggested an increased risk of wound infections when BioGlue® is used as dural sealant in cranial surgery, due to a pyogenic and chronic inflammatory response.…”