Short-term topical treatment of wlvovaginal candidiasis with the combination of 5-fluorocytosine and candicidin

Abstract

A combination of 5-fluorocytosine (1000 mg) and candicidin (5 mg) was compared with clotrimazole (100 mg) in the treatment of 112 non-pregnant volunteers with vulvovaginal candidiasis. Seventy-two (75%) of the 96 patients treated with 1 or 2 vaginal tablets of the combination product and 10 (62%) of the 16 women treated with clotrimazole for 6 days were cured. The efficacy of the treatments was assessed mycologically and clinically 1 week and 1 month after the therapy. Both treatments were well tolerated and no side-effects could be detected. It is concluded that a short-term vaginal treatment with a 5-fluorocytosine and candicidin combination is effective in vaginal moniliasis, and the brevity of the treatment is an advantage compared with others now available.

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides

“…Candicidin was used to treat vaginal candidiasis (332)(333)(334) and prostatic hyperplasia (335). A unique new 52-membered ring cyclic β-glucan, α-cyclosophorohexadecaose 300, was purified from cultures of Xanthomonas campestris (342).…”