Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial

Cuadros-Fernández, C; Rodríguez, Antonio; Sáez-Martínez, S; García-Binimelis, J; About, Imad; Mercadé, Montse

doi:10.1007/s00784-015-1656-4

Cited by 82 publications

(81 citation statements)

References 34 publications

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“…The most studied calcium silicate based cement was Biodentine (Septodont, France), that had been recommended even for temporary restorative material. Similar outcomes as regards tertiary dentin formation and inflammatory response between Biodentine and MTA were demonstrated in an animal experiment; in an ex vivo study with human teeth; and in a recent clinical trial when used for pulpotomies of primary molars after 12 months of follow‐up . Moreover, when used for indirect pulp capping, Biodentine showed similar clinical results to those of a glass ionomer cement (Fuji IX, GC Corporation, USA) after 12 months of follow‐up …”

Section: Discussionsupporting

confidence: 64%

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Current trends and future perspectives of dental pulp capping materials: A systematic review

et al. 2017

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To systematically review the literature to analyze the current trends and future perspectives of dental pulp capping materials through an analysis of scientific and technological data. This study is reported in accordance with the PRISMA Statement. Nine databases were screened: PubMed (MedLine), Lilacs, IBECS, BBO, Web of Science, Scopus, SciELO, Google Scholar, and The Cochrane Library. Additionally, the following patent applications were searched online in Questel Orbit (Paris, France), USPTO, EPO, JPO, INPI, and Patentscope databases. A total of 716 papers and 83 patents were included. Calcium hydroxide was the main type of material studied, especially for direct pulp capping, followed by MTA. Patents related to adhesives or resins increased from 1998 e 2008, while in the last years, a major increase was observed in bioactive materials (containing bioactive proteins), materials derived from MTA (calcium silicate, calcium phosphate and calcium aluminate-based cements) and MTA. It was possible to obtain a scientific and technological overview of pulp capping materials. MTA has shown favorable results in vital pulp therapy that seem to surpass the disadvantages of calcium hydroxide. Recent advances in bioactive materials and those derived from MTA have shown promising results that could improve biomaterials used in vital pulp treatments. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1358-1368, 2018.

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Section: Discussionsupporting

confidence: 64%

“…Later, he introduced a commercial formula that consisted of 19% formaldehyde, 35% cresol and glycerin in distilled water . Although formocresol has long been considered the gold standard in pulpotomy, researchers have been questioning its use due to possible toxic effects …”

Section: Discussionmentioning

confidence: 99%

Current trends and future perspectives of dental pulp capping materials: A systematic review

et al. 2017

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“…They have improved properties compared to MTA, such as good sealing correlated to expansion, being able to set in the presence of fluids, releasing ions such as calcium and having good biological properties (Da Rosa et al 2017). Similar outcomes regarding tertiary dentine formation and inflammatory response between calcium silicate-based cement (Biodentine) and MTA (ProRoot MTA; Dentsply Sirona, Ballaigues, Switzerland) have been demonstrated (Nowicka et al 2013, De Rossi et al 2014, Cuadros-Fernandez et al 2015. iRoot BP Plus; Innovative Bioceramix, Vancouver, Canada, and Biodentine; Septodont, Saint Maur des Foss es, France) have been reported to induce odontoblastic differentiation by activating the MAPK/ERK (Jung et al 2015), NF-jb, p38 MAPK and JNK pathways (Rathinam et al 2015).…”

Section: Current Challenges and Future Directionsmentioning

confidence: 95%

Disclosing the physiology of pulp tissue for vital pulp therapy

2018

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The discovery that dentine is a reservoir of bioactive molecules that can be recruited on demand has attracted efforts to develop new protocols and materials for vital pulp therapy (VPT). The noncollagenous proteins (NCPs) present in the dentine extracellular matrix (ECM) include growth factors (TGF-β1, BMP-7, FGF-2, IGF-1 and IGF-2, NGF and GDNF), extracellular matrix molecules (DSP, DPP, BSP, DMP-1 and DSPP) and both anti-inflammatory and pro-inflammatory chemokines and cytokines (TNF-α, IL-1, IL-6 and IL-10). Molecules such as DSP and DPP are mainly expressed by odontoblasts, and they are cleaved products from dentine sialophosphoprotein (DSPP). Some molecules, such as TGF-β1, specifically interact with decorin/biglycan in dentine. Although TGF-β1 increases the expression and secretion of NGF in human pulp cells, NGF induces mineralization and increases the expression of DSPP and DMP-1. Furthermore, GDNF may act as a cell survival factor and mitogen during tooth injury and repair. Pulp capping materials, such as MTA and calcium hydroxide, can solubilize bioactive dentine molecules (TGF-β1, NGF and GDNF) that stimulate tertiary dentinogenesis. The binding of these signalling molecules leads to activation of several signalling transduction pathways involved in dentinogenesis, odontoblast differentiation and inflammatory responses, such as the p38 MAPK, NF-kβ and Wnt/β-catenin signalling pathways. Understanding the cascade of cellular and molecular events underlying the repair and regeneration processes provides a reasonable new approach to VPT through a targeted interaction between tooth tissue and bioactive molecules.

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“…2,3 Compared to the mineral trioxide aggregate (MTA) that can be used for pulpotomies, Biodentine has greater biocompatibility, bioactivity, biomineralization, and improved antibacterial properties, in addition to its low cytotoxic effect. [4][5] Fernandez et al 6 have reported a high clinical and radiographic progress using both Biodentine and MTA as pulp-dressing agents in primary molar pulpotomies. A tomographic evaluation by Nowicka et al 7 demonstrated that Biodentine provided thicker dentin bridges in human molars than MTA or other materials.…”

Section: Introductionmentioning

confidence: 99%

Shear Bond Strength of Composite and Compomer to Biodentine® Applied With Various Bonding Agents: An in-Vitro Study

KELEŞ¹,

DERELİOĞLU²

2020

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial

Abstract: This article demonstrates the effectiveness of Biodentine as a primary teeth pulpotomy material, performing similar results as MTA at 12-months evaluation.

Cited by 82 publications

References 34 publications

Current trends and future perspectives of dental pulp capping materials: A systematic review

Current trends and future perspectives of dental pulp capping materials: A systematic review

Disclosing the physiology of pulp tissue for vital pulp therapy

Shear Bond Strength of Composite and Compomer to Biodentine® Applied With Various Bonding Agents: An in-Vitro Study

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