Short-term variation in labeling index as a predictor of radiotherapy response in human oral cavity carcinoma

Silvestrini, Rosella; Molinari, Roberto; Costa, Aurora; Volterrani, F; Gardani, G

doi:10.1016/0360-3016(84)90164-0

Cited by 34 publications

(16 citation statements)

References 22 publications

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“…The median Ts measured in this study of 11.5 h is similar to that previously reported for oral cancers (Sakuma, 1980;Silvestrini et al, 1984). Recent in vivo studies have reported short mean Ts values of between 10-12 h and short median potential doubling times of 4-5 days which agree well with our values (Wilson et al, 1988;Begg et al, 1990).…”

Section: Discussionsupporting

confidence: 92%

“…The method developed by Begg et al (1985) (Friedlander et al, 1984;Volm et al, 1985) including some head and neck tumours (Holm, 1982;Franzen et al, 1986) 11.5 7.9 14.8 P<0.01 (2.6-30.0) (2.6-14.7) (7.6-30.0) in breast cancer where high TLI correlates with reduced survival (Meyer & Hixon, 1979;Gentili et al, 1981) and may also predict tumour radio and chemosensitivity (Silvestrini et al, 1984). The relationship between TLI and prognosis is not so well established in head and neck cancer where unlike in breast cancer the median TLI fails to divide patients into two groups with significantly different outlook (Courdi et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Much larger cohorts of patients have been studied using in vitro thymidine labelling. Three such studies (Chauvaudra et al, 1979;Silvestrini et al, 1984; reported a median value of 11% for head and neck tumours. Agreement between labelling indices determined from in vitro and in vivo labelling experiments is difficult to assess, but indirect evidence from simple comparisons of separate studies show the range of values are comparable.…”

Section: Discussionmentioning

confidence: 99%

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Tumour growth rates in squamous carcinoma of the head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry

Forster

Cooke²,

Cooke³

et al. 1992

Br J Cancer

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Summary The cell kinetics of 82 squamous cell carcinomas of the head and neck were studied by in vivo administration of the thymidine analogue, bromodeoxyuridine (BrdUrd). Ploidy, BrdUrd labelling index (LI), duration of S-phase (Ts), potential doubling time (Tpot) and S-phase (Steel, 1977;Meyer, 1982). Cell kinetic studies in man, until recently, have been limited to in vitro investigations because of the ethical constraints of administering radioactive DNA precursors to patients. Tritiated thymidine labelling of freshly excised tissue followed by autoradiography has been widely used (Gentili et al., 1981;Brandt & Olsson, 1987;Courdi et al., 1989;Meyer & Bauer, 1975). The development of flow cytometric methods for measuring DNA content, particularly in paraffin embedded archival material, has resulted in DNA ploidy and S-phase fraction analysis being performed for many tumour types (Cornelisse et al., 1987;Armitage, 1985;Feichter et al., 1987

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tumour growth rates in squamous carcinoma of the head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry

Forster

Cooke²,

Cooke³

et al. 1992

Br J Cancer

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“…Our median LI values in breast cancer as well as in head and neck cancer are close to those of others (Gentili et al, 1981;Silvestrini et al, 1984). Yet, in breast cancer, the median LI seems to be an adequate cut-off to distinguish between two groups of patients with different outcome.…”

supporting

confidence: 77%

“…The few studies which have addressed the role of the proportion of S-phase cells on prognosis in head and neck cancer have reached no clear-cut conclusions (Courdi et al, 1980;Silvestrini et al, 1984;Muller et al, 1985). This work suggests that a higher than median cut-off is more optimal for predicting outcome.…”

mentioning

confidence: 83%

Prognostic value of continuous variables in breast cancer and head and neck cancer. Dependence on the cut-off level

Courdi

Héry²,

Chauvel³

et al. 1988

Br J Cancer

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Changes in cell kinetics induced by primary chemotherapy in breast cancer

Daidone

Silvestrini

Valentinis

et al. 1991

Intl Journal of Cancer

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Changes in the 3H-thymidine labelling index (3H-TdR LI) of primary tumor induced by cytoreductive chemotherapy were evaluated in 26 patients with locally advanced breast cancer subjected to mastectomy after different systemic therapies. A significant reduction of 3H-TdR LI by primary chemotherapy was observed in 11 cases. Changes in cell kinetics were related to the pretreatment proliferative activity: significant increases were observed in 70% of tumors with a very low 3H-TdR LI (less than 25%) and significant decreases in 100% of tumors with a very high 3H-TdR LI (greater than 7.0%). There was no correlation between pretreatment 3H-TdR LI and the objective clinical response, which was conversely related to posttreatment cell kinetics. The 2-year progression rate was lower for patients whose residual tumors after treatment had remained (2/7) or become (1/8) slowly proliferating than for patients whose tumors had remained (5/7) or become (4/4) rapidly proliferating.

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Short-term variation in labeling index as a predictor of radiotherapy response in human oral cavity carcinoma

Cited by 34 publications

References 22 publications

Tumour growth rates in squamous carcinoma of the head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry

Tumour growth rates in squamous carcinoma of the head and neck measured by in vivo bromodeoxyuridine incorporation and flow cytometry

Prognostic value of continuous variables in breast cancer and head and neck cancer. Dependence on the cut-off level

Changes in cell kinetics induced by primary chemotherapy in breast cancer

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