Purpose: To evaluate the visual outcomes and satisfaction of patients with enhanced monofocal intraocular lenses (IOL) implanted during phacovitrectomy. Methods: A university hospital, retrospective, non-comparative pilot study. The main outcome measures were uncorrected near visual acuity (UNVA), uncorrected intermediate visual acuity (UIVA), uncorrected and corrected distance visual acuity (UDVA and CDVA, respectively), and the image through the IOL to assess the quality of the intraoperative view. Patient satisfaction was assessed using a 3-month follow-up questionnaire.Results: This study included 20 eyes that underwent phacovitrectomy with implantation of an enhanced monofocal IOL (TECNIS Eyhance ICB00; Johnson & Johnson Surgical Vision, Santa Ana, CA, USA). The most common cause of vitrectomy was epiretinal membrane in 15 eyes (75%), followed by mild vitreous hemorrhage in three eyes (15%) and vitreous opacity in two eyes (10%). There was no difference between the view through the enhanced monofocal IOL and that through the monofocal IOL (TECNIS ® ZCB00; Johnson & Johnson Surgical Vision, Santa Ana, CA, USA). The mean 3-month postoperative CDVA, UDVA, and UIVA were 0.10 ± 0.15, 0.15 ± 0.11, and 0.30 ± 0.14 (logarithm of the minimum angle of resolution), respectively; the improvements were statistically significant (p < 0.001). The mean 3-month postoperative UNVA was 0.50 ± 0.12, showing no significant difference (p = 0.803). The mean general and intermediate quality of vision scores were 9.13 ± 0.73 and 7.4 ± 0.25, respectively (0: very dissatisfied; 10: very satisfied). Out of 20 patients, 17 (85%) were satisfied with their intermediate vision; some reported glare (2 [10%]) and halo (1 [5%]). Conclusions: Combined vitrectomy and cataract surgery with enhanced monofocal IOL implantation led to favorable visual outcomes at far and intermediate distances and high patient satisfaction.