Short-Wavelength Automated Perimetry and Standard Perimetry in the Detection of Progressive Optic Disc Cupping

Abstract

Objective: To compare progression in shortwavelength automated perimetry (SWAP) and white-onwhite (standard) perimetry in eyes with progressive glaucomatous changes of the optic disc detected by serial stereophotographs. Methods: Forty-seven glaucoma patients with at least 2 disc stereophotographs more than 2 years apart, along with standard perimetry and SWAP examinations within 6 months of each disc photo of the same eye, were included in the study. The mean follow-up time was 4.1 years (range, 2.0-8.9 years). Baseline and follow-up stereophotographs were then graded and compared for the presence of progression. Progression in standard perimetry and SWAP, using the Advanced Glaucoma Intervention Study scoring system and a clinical scoring system, was compared between eyes with progressive change on stereophotographs and those without. Results: Twenty-two of 47 eyes showed progressive change by stereophotographs. There was a statistically significant difference in the mean change in Advanced Glaucoma Intervention Study scores for both standard perimetry (PϽ.004) and SWAP (PϽ.001) between the progressed and nonprogressed groups. The sensitivity, specificity, and area under the receiver operator characteristic curve were higher using SWAP than standard perimetry when evaluated by either algorithm. This was statistically significant only in the area under the receiver operator characteristic curve for the Advanced Glaucoma Intervention Study scoring system (P=.04). Conclusions: Short-wavelength automated perimetry identified more patients than standard perimetry as having progressive glaucomatous changes of the optic disc. Compared with standard perimetry, SWAP may improve the detection of progressive glaucoma.

Correlation between blue-on-yellow perimetry and scanning laser polarimetry with variable corneal compensation measurements in primary open-angle glaucoma

“…11,12,32,33 Previous studies have shown that B/YP is highly sensitive to early glaucoma visual fi eld defects and can predict the development of glaucomatous visual fi eld loss. [8][9][10]12,32 Johnson et al 12 reported that in patients with ocular hypertension, B/YP can reveal early fi eld losses before defi cits can be detected by conventional W/WP. Ferreras et al 34 found that in cases of suspected glaucoma, B/YP detected functional losses before glaucomatous losses were detected by W/WP.…”

“…[1][2][3][4][5][6][7] Other studies have shown that unconventional perimetry such as blue-on-yellow perimetry (B/YP) can detect visual fi eld damage earlier than standard white-onwhite perimetry (W/WP). [8][9][10] Both unconventional perimetry and the RNFL can thus be used to detect early glaucomatous damage by different approaches.…”

“…11 Many studies confi rm that B/YP is a highly sensitive method for detecting visual fi eld defects and predicting the development of visual fi eld loss in glaucoma. [8][9][10]12 RNFL defects can be identifi ed earlier morphologically than with white-on-white visual fi eld testing because detection of defects by standard threshold perimetry at any location in the visual fi eld may not be possible before 30% of retinal ganglion cells at the corresponding retinal location have been lost. 1 The RNFL exhibits substantial linear birefringence with the slow axis parallel to the direction of nerve fi ber bundles.…”

Recent developments in perimetry: test stimuli and procedures

“…29 SWAP has some clinical advantages over white-on-white perimetry. SWAP is more sensitive than white-on-white perimetry for the detection of early glaucomatous visual field loss, 21,29,30 is superior to white-on-white perimetry in identifying patients with progressive optic disc cupping 31 and detects visual field loss earlier in patients with ocular hypertension. 30 SWAP is effective in identifying visual field abnormalities in a range of conditions other than glaucoma, such as diabetic retinopathy.…”

Comparison of Functional and Morphological Diagnostics in Glaucoma Patients and Healthy Subjects

“…Blue-on-yellow perimetry (B/YP) is a type of visual field examination technique, which is a combined method of visual field test and colour vision test. Previous studies have shown that the B/YP is a high-sensitivity method for detecting early visual field defects and predicting the development of visual field loss in glaucoma [23,24,25,26]. …”