Short-wavelength automated perimetry results are correlated with optical coherence tomography retinal nerve fiber layer thickness measurements in glaucomatous eyes

Sánchez-Galeana, César A; Bowd, Christopher; Zangwill, Linda M.; Sample, Pamela A.; Weinreb, Robert N.

doi:10.1016/j.ophtha.2004.04.017

Cited by 31 publications

(19 citation statements)

References 25 publications

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“…27 Sanchez-Galeana et al found a statistically significant correlation between RNFL loss and short-wavelength automated perimetry (SWAP) deficiency. 28 On the other hand, Mastropasqua et al demonstrated that SWAP showed a significant reduction in CPSD after administration of brimonidine; 6 however, there was no control group in their study. More recently, contrast sensitivity improvement was found following brimonidine 0.2% therapy, as compared to timolol gel 0.5%, after 3 months of treatment.…”

Section: Tsai and Chang 480mentioning

confidence: 85%

Comparison of the Effects of Brimonidine 0.2% and Timolol 0.5% on Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive Patients: A Prospective, Unmasked Study

Tsai

Chang

2005

Journal of Ocular Pharmacology and Therapeutics

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Section: Tsai and Chang 480mentioning

confidence: 85%

Comparison of the Effects of Brimonidine 0.2% and Timolol 0.5% on Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive Patients: A Prospective, Unmasked Study

Tsai

Chang

2005

Journal of Ocular Pharmacology and Therapeutics

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“…38,39 Numerous studies have shown the value of earlier OCT versions and Stratus-OCT in OHT and early glaucoma. 22,32,[40][41][42] Our study shows that 13 out of 21 Stratus-OCT parameters were statistically significant different between OHT eyes with normal FDT results and those with FDT abnormalities (Tables 2 and 3; Figures 1 and 2). This finding suggests that patients with FDT VF defects may have more structural damage compared to those in whom no FDT defects have developed.…”

Section: Discussionmentioning

confidence: 96%

Stratus-OCT imaging in early glaucomatous and in ocular hypertensive patients with and without frequency-doubling technology abnormalities

Brusini

Zeppieri

Tosoni

et al. 2007

Eye

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Aim To compare Stratus-OCT measurements in controls, ocular hypertensive (OHT) patients with (FDT þ ) and without (FDTÀ) frequency-doubling technology (FDT) abnormalities, and in patients affected with early primary open-angle glaucoma (POAG). Methods Thirty-two controls, 78 OHT patients (38 FDTÀ and 40 FDT þ ), and 45 early POAG patients (six FDTÀ and 39 FDT þ ) underwent the following tests within 3 months: standard automated perimetry (SAP) HFA 30-2; FDT N-30-F; and, Stratus-OCT imaging with retinal nerve fibre layer (RNFL) and optic nerve head (ONH) scans. One eye per patient was considered. Differences among groups were evaluated using the Kruskal-Wallis, analysis of variance, and Duncan's tests. Results There were no significant differences in all Stratus-OCT parameters between POAG and OHT FDT þ patients. Statistically significant differences were found between the control group and both the POAG and OHT FDT þ groups for 15 of the 21 Stratus-OCT parameters. Control eyes compared to OHT FDTÀ showed significant differences in 13 of the 21 parameters. The comparison between the OHT FDTÀ group, and both the POAG and OHT FDT þ group resulted in 13 of the 21 parameters to be significantly different.Conclusions Stratus-OCT seems to show a higher ability in detecting significant differences between healthy, OHT, and early POAG eyes when compared to SAP and FDT. This suggests that the Stratus-OCT could show structural abnormalities before SAP or FDT visual field defects appear in patients at risk of developing glaucoma, which may be beneficial in making therapeutic decisions, especially in OHT patients.

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“…In previous studies, Sanchez-Galeana et al [28] found that RNFL thickness measured with OCT was topographically correlated with glaucomatous visual field defects measured with B/YP. Zhong et al [29] reported only a mild correlation between B/YP and OCT for preperimetric glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Functional and Morphological Diagnostics in Glaucoma Patients and Healthy Subjects

Klamann

Grünert²,

Maier³

et al. 2013

Ophthalmic Res

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Purpose: To evaluate the diagnostic value of microperimetry (MP), blue-on-yellow perimetry (B/YP), confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph, HRT, III) and optical coherence tomography (OCT) in discriminating eyes with early glaucoma from healthy subjects. Material and Methods: Prospective examination of 22 eyes of subjects with early primary open-angle glaucoma and 24 eyes of healthy control subjects. After a complete ophthalmological examination, B/YP, MP, OCT and HRT III were determined. Morphological and functional parameters were analysed. Results: Mean sensitivity threshold values obtained with B/YP and MP did not show significant differences between glaucoma patients and the control group (p = 0.321 and p = 0.281). Retinal nerve fibre layer (RNFL) thickness was significantly decreased in patients with glaucoma with both HRT III and OCT (p = 0.018 and p < 0.001). Conclusions: While B/YP and MP had no ability to discriminate between subjects with early glaucoma and healthy subjects, RNFL thickness measured with HRT III and OCT showed a significant difference. In early primary open-angle glaucoma, morphological changes like RNFL thickness seem to occur prior to functional defects in the visual field.

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Short-wavelength automated perimetry results are correlated with optical coherence tomography retinal nerve fiber layer thickness measurements in glaucomatous eyes

Cited by 31 publications

References 25 publications

Comparison of the Effects of Brimonidine 0.2% and Timolol 0.5% on Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive Patients: A Prospective, Unmasked Study

Comparison of the Effects of Brimonidine 0.2% and Timolol 0.5% on Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive Patients: A Prospective, Unmasked Study

Stratus-OCT imaging in early glaucomatous and in ocular hypertensive patients with and without frequency-doubling technology abnormalities

Comparison of Functional and Morphological Diagnostics in Glaucoma Patients and Healthy Subjects

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