Should intravenous acetaminophen be considered for post craniotomy pain management? A meta-analysis of randomized controlled trials

Ebada, Mahmoud Ahmed; Ali, Ahmed Said; Elshakankiry, Abdelrahman; Essa, Tarek Mohamed; Khater, Ahmad G. A.; Hossam, Mohamed; Al-Shami, Hieder; Bahbah, Eshak I.; Ghaith, Hazem S.; Kanmounye, Ulrick Sidney; Negida, Ahmed

doi:10.23736/s0390-5616.21.05402-3

“…Preoperative bodily pain may more strongly contribute to postoperative chronic pain than preoperative mental health; however, there was a weak relationship between bodily pain and mental health (Spearman's correlation coe cient was 0.37, p < 0.001). Some drugs, including dexmedetomidine and acetaminophen, decrease post-craniotomy pain (20,21), which was inconsistent with our results. This could be attributed to our small sample size.…”

Section: Resultscontrasting

confidence: 99%

Persistent incisional pain at 1 year after craniotomy: a retrospective observational study

Phoowanakulchai

¹

,

Ida

²

,

Naito

³

et al. 2023

Preprint

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Background There have been few reports on persistent incisional pain at 1 year after craniotomy. Hence, this study aimed to explore the distribution of pain at 1 year after elective craniotomy and its related factors. Methods This retrospective study included data prospectively collected to assess postoperative functional disability. We included patients aged > 55 years at the time of recruitment for our initial study and who had complete data regarding the pain numeric rating scale (NRS) score at 1 year post craniotomy. The primary outcome was the pain NRS score, which was assessed at the postanesthetic clinic as well as at 3 months and 1 year after craniotomy. Multivariable negative binomial regression analysis was performed to analyze the relationship between the pain NRS score at 1 postoperative year and 12 clinically meaningful covariates. These included the Short Form-8 scores for bodily pain and mental health, with higher scores indicating better health. Results We analyzed data from 102 patients. The mean (95% confidence interval) pain NRS scores at the three measurement points were 2.8 (2.3–3.3), 1.2 (0.8–1.6), and 0.6 (0.3–0.8), respectively. Multivariable analysis revealed that preoperative bodily pain (risk ratio, 0.93; 95% confidence interval, 0.88–0.98) and the pain NRS score at the postanesthetic clinic (risk ratio, 1.32; 95% confidence interval, 1.14–1.52) were associated with the risk of persistent pain at 1 postoperative year. Conclusions The pain score at 1 year after elective craniotomy was minor; however, preoperative bodily pain and postoperative pain scores were significantly related factors.

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“…Some drugs, including dexmedetomidine and acetaminophen, decrease post-craniotomy pain [ 19 , 20 ], which was inconsistent with our results. This could be attributed to our small sample size.…”

Section: Discussioncontrasting

confidence: 97%

Persistent incisional pain at 1 year after craniotomy: a retrospective observational study

Phoowanakulchai

¹

,

Ida

²

,

Naito

³

et al. 2023

BMC Anesthesiol

1

0

View full text Add to dashboard Cite

Background There have been few reports on persistent incisional pain at 1 year after craniotomy. Hence, this study aimed to explore the distribution of pain at 1 year after elective craniotomy and its related factors. Methods This retrospective study included data prospectively collected to assess postoperative functional disability. We included patients aged > 55 years at the time of recruitment for our initial study and who had complete data regarding the pain numeric rating scale (NRS) score at 1 year post craniotomy. The primary outcome was the pain NRS score, which was assessed at the postanesthetic clinic as well as at 3 months and 1 year after craniotomy. Multivariable negative binomial regression analysis was performed to analyze the relationship between the pain NRS score at 1 postoperative year and 12 clinically meaningful covariates. These included the Short Form-8 scores for bodily pain and mental health, with higher scores indicating better health. Results We analyzed data from 102 patients. The mean (95% confidence interval) pain NRS scores at the three measurement points were 2.8 (2.3–3.3), 1.2 (0.8–1.6), and 0.6 (0.3–0.8), respectively. Multivariable analysis revealed that preoperative bodily pain (risk ratio, 0.93; 95% confidence interval, 0.88–0.98) and the pain NRS score at the postanesthetic clinic (risk ratio, 1.32; 95% confidence interval, 1.14–1.52) were associated with the risk of persistent pain at 1 postoperative year. Conclusions The pain score at 1 year after elective craniotomy was minor; however, preoperative bodily pain and postoperative pain scores were significantly related factors.

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Post Awake Craniotomy Care <Postoperative Care, Pain, Seizures, Postoperative Nausea and Vomiting>

Krzyżewski

¹

,

Albuquerque

²

2023

The Principles of Successful Awake Craniotomy

0

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Should intravenous acetaminophen be considered for post craniotomy pain management? A meta-analysis of randomized controlled trials

Cited by 4 publications

References 24 publications

Persistent incisional pain at 1 year after craniotomy: a retrospective observational study

Persistent incisional pain at 1 year after craniotomy: a retrospective observational study

Persistent incisional pain at 1 year after craniotomy: a retrospective observational study

Post Awake Craniotomy Care <Postoperative Care, Pain, Seizures, Postoperative Nausea and Vomiting>

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