Should the indications for the use of myeloid growth factors for the prevention of febrile neutropenia in cancer patients be extended?

Klastersky, Jean; Awada, Ahmad; Aoun, Michel; Paesmans, Marianne

doi:10.1097/cco.0b013e32832c9651

Cited by 16 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human guidelines do not routinely recommend adjunctive administration of G‐CSF in febrile neutropenic patients, save for those patients deemed at high risk for complications or poor clinical outcome based on predictive models, as treatment with G‐CSF post‐admission has not consistently shown benefit in hospitalized patients with FN . Haematopoietic growth factors have a well‐defined prophylactic role in the human arena, however, and are currently recommended in cancer patients receiving chemotherapy if the risk of developing FN is deemed equal to or greater than 20%, due to significant reduction in the incidence of chemotherapy‐induced FN, the severity and duration of neutropenia and infection‐related mortality in patients with both solid and haematological malignancies . In veterinary medicine, the administration of myeloid growth factors has hitherto been limited due to issues of cost, availability and concern regarding side effects, as well as a relative lack of prospective evidence informing their ideal usage …”

Section: Discussionmentioning

confidence: 99%

Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997–2010)

Britton

Kelleher

Gregor

et al. 2012

Vet Comparative Oncology

View full text Add to dashboard Cite

Febrile neutropenia (FN) is an important sequela in veterinary patients receiving chemotherapy. The purpose of this study was to identify factors associated with prolonged hospital stay and outcome in canine patients developing FN secondary to chemotherapy administration. Medical records of 70 dogs treated for FN at the University of Pennsylvania from 1997 to 2010 were retrospectively evaluated. The mean interval between chemotherapy and hospitalization was 7 days. Two-thirds of treated patients had lymphoma. The majority of patients (70%) received vincristine or doxorubicin prior to the development of FN. Tachycardia at admission, complicating medical issues, G-CSF use and decreasing neutrophil count after admission were associated with prolonged hospital stay. Hypotension and G-CSF use were significantly associated with death in-hospital. Mortality was 8.5%. Identification of factors associated with prolonged hospital stay and mortality in patients with FN may enable the development of risk-adapted treatment guidelines to minimize chemotherapy-associated morbidity and mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997–2010)

Britton

Kelleher

Gregor

et al. 2012

Vet Comparative Oncology

View full text Add to dashboard Cite

show abstract

“…Currently, international guidelines recommend the use of G-CSF as primary prophylaxis when there is an increased risk of febrile neutropenia of greater than or equal to 20%, although the broader use of prophylactic CSF has been suggested 118,124 . How extensively a non-toxic agent is used is based in part on economic criteria and, when the costs of CSFs are reduced with the introduction of generic CSFs, the occasions on which CSFs may usefully be employed should increase.…”

Section: Clinical Trials Of Csfs and Therapeutic Applicationsmentioning

confidence: 99%

The colony-stimulating factors and cancer

Metcalf¹

2010

Nat Rev Cancer

138

View full text Add to dashboard Cite

The four colony stimulating factors (CSFs) are glycoproteins regulating the generation and some functions of infection-protective granulocytes and macrophages. Recombinant G-CSF and GM-CSF have now been used to elevate dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood (PBSC) and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients with treatment-induced bone marrow damage.

show abstract

“…Declines in WBC subsets can result in delays in chemotherapy and reductions in dosage (Khan et al 2008) and increased risk of infection, mortality and hospital admissions (Klastersky et al 2009). Similarly, declines in RBC indices can exacerbate fatigue, reduce quality of life, result in delays in treatment, and have a negative impact on survival (Hauser et al 2006; Pirker et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of an exercise training intervention with resistance bands on blood cell counts during chemotherapy for lung cancer: a pilot randomized controlled trial

et al. 2014

View full text Add to dashboard Cite

PurposeChemotherapy for lung cancer can have a detrimental effect on white blood cell (WBC) and red blood cell (RBC) counts. Physical exercise may have a role in improving WBCs and RBCs, although few studies have examined cancer patients receiving adjuvant therapies. The purpose of this pilot trial was to examine the effects of an exercise intervention utilizing resistance bands on WBCs and RBCs in lung cancer patients receiving curative intent chemotherapy.MethodsA sample of lung cancer patients scheduled for curative intent chemotherapy was randomly assigned to the exercise intervention (EX) condition or usual care (UC) condition. The EX condition participated in a three times weekly exercise program using resistance bands for the duration of chemotherapy.ResultsA total of 14 lung cancer patients completed the trial. EX condition participants completed 79% of planned exercise sessions. The EX condition was able to maintain WBCs over the course of the intervention compared to declines in the UC condition (p = .008; d = 1.68). There were no significant differences in change scores in RBCs.ConclusionsExercise with resistance bands may help attenuate declines in WBCs in lung cancer patients receiving curative intent chemotherapy. Larger trials are warranted to validate these findings. Ultimately these findings could be informative for the development of supportive care strategies for lung cancer patients receiving chemotherapy.Trial registrationClinical Trials Registration #: NCT01130714.

show abstract

Should the indications for the use of myeloid growth factors for the prevention of febrile neutropenia in cancer patients be extended?

Cited by 16 publications

References 23 publications

Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997–2010)

Evaluation of factors associated with prolonged hospital stay and outcome of febrile neutropenic patients receiving chemotherapy: 70 cases (1997–2010)

The colony-stimulating factors and cancer

Effect of an exercise training intervention with resistance bands on blood cell counts during chemotherapy for lung cancer: a pilot randomized controlled trial

Contact Info

Product

Resources

About