SHP-1 sensitizes MCF-7 cells to trichostatin A-induced apoptosis by modulating PI3K-dependent events

Xu, Yiming; Dd, Mousseau; Banville, Denis; Zhao, Xin; Sh, Shen

doi:10.1038/sj.cdd.4401292

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…On the other hand, in the human breast cancer cell line MCF-7, a role for SHP-1 as a positive regulator of cell death has been suggested. Indeed, the resistance of MCF-7 cells to trichostatin A-induced apoptosis is decreased by stable overexpression of SHP-1, likely by a mechanism that involves the phosphatidylinositol 3-kinase pathway [15]. A function of SHP-1 as a positive regulator of cell death is further supported by the finding that it may act as a TrkA phosphatase, balancing the level of TrkA-induced cell survival in cultured neurons and PC12 cells [16].…”

Section: Introductionmentioning

confidence: 65%

Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors

Insabato

Amelio²,

Quarto³

et al. 2009

Oncology

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Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.

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Section: Introductionmentioning

confidence: 65%