Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway

Tao, Zhengang; Gao, Jingyan; Zhang, Guoliang; Xue, Mingming; Yang, Weiqiang; Tong, Caoyang; Yuan, Ying

doi:10.5582/bst.8.45

Cited by 33 publications

(26 citation statements)

References 29 publications

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“…SJC is widely used as an antipyretic and anti-inflammatory medicine [6,[28][29][30], especially for the treatment of acute upper respiratory tract infections [31], which may involve the ERK signaling pathway. Although it has shown significant effects for the treatment of sore throat, headache, nasal congestion, flow turbidity, and pulmonary embolism, most other studies on SJC have focused on single chemical composition analysis.…”

Section: Discussionmentioning

confidence: 99%

Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

Yuan

Liao

Xue

et al. 2018

Cell Physiol Biochem

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Background/Aims: Acute respiratory tract infection (ARTI) is the most common reason for outpatient physician office visits. Although powerful and significant in the treatment of infections, antibiotics used for ARTI inappropriately have been an important contributor to antibiotic resistance. We previously reported that Shufeng Jiedu Capsule (SJC) can effectively amplify anti-inflammatory signaling during infection. In this study, we aimed to systematically explore its composition and the mechanism of its effects in ARTI. Methods: Pseudomonas aeruginosa (PAK) strain was used to generate a mouse model of ARTI, which were then treated with different drugs or compounds to determine the corresponding anti-inflammatory roles. High-performance liquid chromatography-quadrupole time of flight-tandem mass spectrometry. was conducted to detect the chemical compounds in SJC. RNAs from the lung tissues of mice were prepared for microarray analysis to reveal globally altered genes and the pathways involved after SJC treatment. Results: SJC significantly inhibited the expression and secretion of inflammatory factors from PAK-induced mouse lung tissues or lipopolysaccharide-induced peritoneal macrophages. Verbenalin, one of the bioactive compounds identified in SJC, also showed notable anti-inflammatory effects. Microarray data revealed numerous differentially expressed genes among the different treatment groups; here, we focused on studying the role of GPR18. We found that the anti-inflammatory role of verbenalin was attenuated in GPR18 knockout mice compared with wild-type mice, although no statistically significant difference was observed in the untreated PAK-induced mice types. Conclusion: Our data not only showed the chemical composition of SJC, but also demonstrated that verbenalin was a significant anti-inflammatory compound, which may function through GPR18.

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Section: Discussionmentioning

confidence: 99%

Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

Yuan

Liao

Xue

et al. 2018

Cell Physiol Biochem

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“…SFJDC are far more potent than Qing-kai-ling granules but weaker than ceftriaxone sodium injection in fighting 6 different bacteria (42). SFJDC protect against ALI by suppressing the MAPK/NF-κB pathway in vivo (43). Proteomic analysis of a rat model of LPS-induced ALI revealed that the anti-inflammatory and immunomodulatory actions of SFJDC are the results of action on the core regulator protein AKT1 in five respects: 1) NF-κB/Nrf2 in the oxidative stress response; 2) the MAPK (ERK1/2 and JNK) signaling pathway; 3) p53/Bcl-2/Caspase in apoptosis; 4) AKT1/ SOCS1 in negative feedback to TLR4 signaling; 5) and AKT/mTOR signaling (38).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review

Huang

Pan

Zhou

et al. 2019

BST

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“…Shufengjiedu capsules (SFJDCs) are a TCM formulation consisting of eight medicinal herbs, Polygonum cuspidatum Sieb. et Zucc., Forsythia suspense (Thunb) Vahl, Isatis indigotica Fort., Bupleurum chinense DC., Thlaspi arvense L., Verbena officindlis (Officinalis) L., Phragmites communistrin Trin, and Glycyrrhiza uralensis Fisch., that are clinically effective at treating upper respiratory tract infections and ALI/ARDS (4). Since SFJDCs have antiviral action, the China Food and Drug Administration (CFDA) has recommended SFJDCs as a treatment for H1N1-and H5N9-induced acute lung injury (5).…”

Section: A L L E Rg I C R H I N I T I S ( a R ) I S T H E M O S T C Omentioning

confidence: 99%

“…Since SFJDCs have antiviral action, the China Food and Drug Administration (CFDA) has recommended SFJDCs as a treatment for H1N1-and H5N9-induced acute lung injury (5). In China, SFJDCs have been listed as a drug to combat avian influenza (4,(6)(7)(8). Studies have reported that active constituents of SFJDCs such as resveratrol and quercetin may alleviate inflammation by suppressing the expression of inflammatory factors via the mitogen-activated protein kinase (MAPK)/nuclear factor-κB (NF-κB) signaling pathway (9)(10)(11).…”

Section: A L L E Rg I C R H I N I T I S ( a R ) I S T H E M O S T C Omentioning

confidence: 99%

Shufengjiedu capsules protect against neuronal loss in olfactory epithelium and lung injury by enhancing autophagy in rats with allergic rhinitis

Mei

Kong

Zhao

et al. 2019

BST

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Shufengjiedu capsules (SFJDCs), a traditional Chinese medicine, have been widely used as an antiviral, antibacterial, antitumor, and anti-inflammatory drug. However, the roles of SFJDCs in allergic rhinitis remain unclear. The purpose of this study was to investigate the effects of SFJDCs in olfaction and lung injury in rats with allergic rhinitis. An animal model of allergic rhinitis was created by intraperitoneal injection and intranasal administration of ovalbumin to rats. All rats were divided into seven groups: a model group, a low-dose SFJDC group, a medium-dose SFJDC group, a high-dose SFJDC group, a cetirizine group, and a control group. Hematoxylin and eosin (HE) staining was used to observe pathological changes in rat lung and olfactory epithelium (OE) tissue, and peripheral blood was collected and subjected to an enzyme-linked immunosorbent assay (ELISA) to detect IgE, tumor necrosis factor alpha (TNF-α), and IL-1ꞵ levels. Western blotting, immunohistochemistry staining, and immunofluorescence staining were performed to detect inflammatory cytokines and levels of the autophagy biomarker beclin1 and the apoptosis biomarker cleaeved-caspased3 in lung and OE tissue. ELISA indicated that SFJDCs significantly decreased IgE, TNF-α, and IL-1ꞵ levels in peripheral blood, the lungs, and OE tissue. In addition, Western blotting and staining indicated that SFJDCs repair lung injury, protect against neuronal apoptosis in OE, and rescue impaired autophagy in the lungs and OE tissue. In conclusion, results indicated that SFJDCs might protect against neuronal loss in the OE and lung injury by enhancing autophagy and decreasing apoptosis in rats with allergic rhinitis. Therefore, SFJDCs might serve as an alternative treatment for allergic rhinitis.

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Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway

Cited by 33 publications

References 29 publications

Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review

Shufengjiedu capsules protect against neuronal loss in olfactory epithelium and lung injury by enhancing autophagy in rats with allergic rhinitis

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