Sialadenoma papilliferum: a case report and immunohistochemical study review

Abstract

Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.Key words: Sialadenoma papilliferum, Hard palate, Immunohistochemistry.[paper submitted 2010. 8. 27 / revised 2010. 11. 30 / accepted 2010. 12. 17] Abstract (J Korean Assoc Oral Maxillofac Surg 2010;36:533-7) *These two authors contributed equally to this work.

An Unusual Cause of Dyspnea

“…S ialadenoma papilliferum (SP) is generally thought of as a rare benign tumor of salivary gland origin. Clinically, it usually occurs in men older than 50, as a painless papillary growth at the junction of the hard and soft palate [1]. It was first described in 1969 by Abrams and Finck [2].…”

“…It was first described in 1969 by Abrams and Finck [2]. The histogenesis of SP remains unclear; some believe that is has an excretory duct while others propose that it originates from salivary ducts [1]. This tumor is best treated by conservative surgical excision, recurrences and malignant transformation are rare.…”

“…This tumor is best treated by conservative surgical excision, recurrences and malignant transformation are rare. Many researchers believe it to have a neoplastic origin, but its precise pathogenesis is not well understood [1].…”