Sialadenoma papilliferum of the bronchus: focus on histological and genetic distinction from mixed squamous cell and glandular papilloma

Sasaki, Eiichi; Iwakoshi, Akari; Masago, Katsuhiro; Hanai, Nobuhiro; Oki, Masahide

doi:10.1016/j.pathol.2020.11.012

Cited by 7 publications

(26 citation statements)

References 10 publications

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“…8 Less common histological features include infiltration of lymphocytes and plasmacytes in the fibrovascular stroma of the papillae (four of 11). 7,8,11 Most of the cases showed no or mild cytological atypia, a few cases showed mild to moderate cytological atypia with rare mitotic figures and necrosis was not found in any case. No oncocytic features, which are characterised by abundant granular cytoplasm and prominent nucleoli in glandular cells, have been observed, while oncocytic types were reported in salivary SP.…”

Section: Histopathological Featuresmentioning

confidence: 96%

“…The first report of pulmonary SP was published in 2003 by Bobos et al and 10 more cases were reported in five papers, including one in Chinese. [6][7][8][9][10][11] Pulmonary SP occurs in the bronchial tree and usually presents as polypoid endobronchial lesions. These lesions originate from the bronchial glands and reflect the histological features of salivary gland tumours.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Together with morphological and immunophenotypical features, the location of the tumour can help to discriminate between SP and GP/MP. 7,11 BA/CMPTs tend to be peripheral and have been reported to be invariably adjacent to bronchioloarterial bundles or penetrated by unpaired medium-sized arteries. 18,24 BA/CMPTs can morphologically mimic SP, especially in cases of squamous metaplasia (Fig- ure 4A-H).…”

Section: Diagnostic Issues and Differential Diagnosismentioning

confidence: 99%

“…Pulmonary SP occurs in the bronchial tree and usually presents as polypoid endobronchial lesions. These lesions originate from the bronchial glands and reflect the histological features of salivary gland tumours 7,8 . The clinical characteristics of the SP cases are summarised in Table 1.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…TTF‐1 was positive in BA/CMPT, which is probably due to its bronchiolar epithelium origin. However, it was negative in SP that showed positive SOX10 staining, because of its bronchial gland intercalated duct origin 7,25 …”

Section: Diagnostic Issues and Differential Diagnosismentioning

confidence: 99%

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Pulmonary sialadenoma papilliferum and its mimics: what you need to know

Gao

Sun

2022

Histopathology

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Pumonary salivary gland‐type tumours (SGT) represent a small but distinct group of primary lung neoplasms. These types of tumours originate from the submucosal bronchial glands of the tracheobronchial tree. Pulmonary SGTs differ greatly in the incidence of individual tumours from salivary gland tumours of the head and neck. Additionally, the vast majority of pulmonary SGT are malignant. Recently, pathological diagnosis has significantly improved with the application of molecular diagnostic technologies. However, the current knowledge of benign SGTs is limited; moreover, tumour diversity and overlapping morphological features of SGT represent diagnostic challenges such as correct tumour categorisation and their accurate differentiation from malignant lesions. Compounding this inherent difficulty has been the recent introduction of new variants, including sialadenoma papilliferum (SP). Pulmonary SP is very rare, with limited reports available, and most of the initial diagnoses rendered so far were incorrect, resulting in inappropriate treatment. Several cases of SP have recently been reported. This review will serve to update practicing pathologists on the morphology, immunophenotype and molecular characteristics of SP and its mimics.

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Section: Histopathological Featuresmentioning

confidence: 96%