Sialadenoma Papilliferum of the Bronchus: A Rare Tumour of Salivary Gland Origin

Abstract

Sialadenoma papilliferum is a benign salivary tumour which rarely occurs in the bronchial tree. Up to now, only four cases of pulmonary papillary sialadenoma have been reported in the literature. We discuss the case of a male patient with an accidental finding of a middle lobe nodule. The patient underwent a minimally invasive anatomical resection of the lobe to remove the lesion; the postoperative course was regular, and he was healthy at the last follow-up.

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

“…SP is a subtype of intraductal papilloma, a rare benign tumour commonly found in older adults with hard palate, accounting for approximately 80%. It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus [2,3,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [3,[32][33][34][35][36][37][38][39][40][41][42][43].…”

“…Sialadenoma papilliferum (SP) is a rare benign neoplasm [1][2][3], estimated to account for less than 1% of all minor salivary gland tumours and 3-5% of head and neck tumours [2][3][4][5][6][7]. It was described initially in 1969 by Abrams and Finck, because of its histomorphology closely resembling that of the syringocystadenoma papilliferum of cutaneous adnexal origin, and a total of 90 cases were reported by 2021 [2][3][4][5]8]. SP is characterized by coexisting papillar and glandular configurations, which occurs mainly in the palate, especially the hard palate.…”

“…It can also occur in the soft palate, buccal mucosa, nasal cavity, upper lip, parotid glands, and rarely in the bronchus and esophagus [9,10]. SP usually presents as a painless exophytic papillary mass with the peak incidence in the fifth, sixth and seventh decades of life [2,5,6,[11][12][13][14][15][16]. The prognosis of SP is mostly good; and in single cases may have recurrence [10] or malignant transformation [12,13].…”

Sialadenoma Papilliferum: With Clinicopathologic, Immunohistochemical, Molecular Analysis, and Review of the Literature

“…SP is a subtype of intraductal papilloma, a rare benign tumor commonly found in middle-aged men with hard palate, accounting for approximately 80 percent. It can also occur in the parotid gland, submandibular gland, nasopharynx and esophagus 2,4,10,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] . Clinically, there are generally no obvious clinical symptoms with mostly painless growth, but sometime papillary erythema or pedicled lumps, occasional ulcers [31][32][33][34][35][36][37][38][39][40][41] .…”

“…Sialadenoma papilliferum (SP) is a rare benign neoplasm 1 , estimated to account for less than 1% of all minor salivary gland tumours and 3-5% of head and neck tumours [2][3][4][5] . It was described initially in 1969 by Abrams and Finck, because of its histomorphology closely resembling that of the syringocystadenoma papilliferum of cutaneous adnexal origin, and a total of only 66 cases were reported by 2020 2,3,6 . SP is characterized by coexisting papillar and glandular con gurations, which occurs mainly in the palate, especially the hard palate.…”