Sialadenoma papilliferum of the parotid gland: Case report and review of literature

Loehn, Bridget; Sutton, Collin; Jastram-Belcher, Jennifer; Harton, Anthony; Anderson, Dwayne; Walvekar, Rohan R.

doi:10.1002/hed.21879

Cited by 12 publications

(8 citation statements)

References 7 publications

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“…Although the first published report of this lesion involved the parotid gland, [4] almost all subsequent case reports and short series have described intraoral lesions. Three additional cases of SP have been reported in the parotid gland, but the photomicrographs are not convincing and likely represent two examples of papillary cystadenoma and one example of Warthin tumor [37][38][39]. Histopathologically, SP is comprised of a papillary epithelial component that resembles squamous papilloma combined with a subjacent unencapsulated salivary gland ductal proliferation that is contiguous with the overlying papillary squamous mucosa.…”

Section: Discussionmentioning

confidence: 99%

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Fowler

Damm

2017

Head and Neck Pathol

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Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location. Other locations in decreasing order were buccal mucosa, upper lip, retromolar pad, and parotid gland. Age at diagnosis ranged from 18 to 87 years with a peak in the 6th decade and an average age of 56.4 years. Microscopically, the lesions demonstrated a papillary surface morphology, and the papillary projections varied from long and pointed to short and blunted. The supporting connective tissue contained a variable number of convoluted ductal structures, which often fused with the overlying surface epithelium. The ductal structures exhibited papillary infoldings and were lined by a double layer of epithelium consisting of basal cell layer and a luminal layer of cuboidal-to-columnar ductal cells. Immunohistochemical reactivity with p63 and p40 indicated that the basal cell layer was comprised predominantly of neoplastic myoepithelial cells. The luminal cells were immunoreactive with epithelial membrane antigen characteristic of ductal cell differentiation. Conservative surgical treatment was accomplished in most cases and appears to be adequate treatment as only two recurrences were documented. Several case reports of purported malignant transformation in SP have been reported in the literature, but in our opinion, there is insufficient evidence in the publications to unequivocally determine whether any of the malignancies truly originated within a pre-existing SP.

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Section: Discussionmentioning

confidence: 99%

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Fowler

Damm

2017

Head and Neck Pathol

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“…Sialadenoma papilliferum (SP) is a rare benign neoplasm [1][2][3], estimated to account for less than 1% of all minor salivary gland tumours and 3-5% of head and neck tumours [2][3][4][5][6][7]. It was described initially in 1969 by Abrams and Finck, because of its histomorphology closely resembling that of the syringocystadenoma papilliferum of cutaneous adnexal origin, and a total of 90 cases were reported by 2021 [2][3][4][5]8]. SP is characterized by coexisting papillar and glandular configurations, which occurs mainly in the palate, especially the hard palate.…”

Section: Introductionmentioning

confidence: 99%

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

et al. 2021

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Background Sialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and five new cases. Methods The clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further performed and the related literatures were reviewed and analyzed. Results Combining 89 cases from the literature with our cases, the hard palate was the most common locations for SP. However, two of our cases were rarely located in the esophageal mucosa. Among all cases, the male gender was more affected, with the average age and median age of 61.8 and 62 years, respectively. Conventional histomorphologically, SP was characterized by complex papillary structures with a biphasic growth pattern of exophytic squamous component and endophytic glandular component. The glandular structures were lined by a double layer of epithelium composed of flattened or cuboidal basal cells and a cuboidal or columnar luminal cells formed papillary infoldings into the ductal lumina. Immunohistochemically, the luminal epithelial configurations showed strong expression of CK7 along the luminal cell membrane, while the basal myoepithelia displayed strong nuclear p63 expression. In both the glandular and squamous tumour components showed BRAF V600E-positive immunostaining and BRAF V600E mutation. Conclusion For the first time, we have comprehensively aggregated and analyzed 90 cases sialadenoma papilliferum from almost all previous publications, and further explored the clinicopathological features of SP; concordantly, this study demonstrated that SP shows a papillomatous growth pattern with exophytic and endophytic proliferation of ductal epithelium composed of double-layered cells harboring BRAF V600E mutation. Additionly, adequate treatment for SP is surgical excision, with a favorable prognosis in patients.

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“…The most common location, as reported in the literature is on the parotid gland. [1][2][3] The salivary gland tumours are usually encountered clinical problems. In the literature, there is inconstancy between the time the tumour is first noticed by the patient and when it is presented to the physician.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of fine needle aspiration biopsy in parotid gland neoplasm

Yeğin

Çelik

Olgun

et al. 2016

Int J Otorhinolaryngol Head Neck Surg

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Background: The value of fine needle aspiration biopsy (FNAB) in the diagnosis of parotid masses remains unclear, considering current literature. The surgical procedure is not planned according to the FNAB results by the majority of the otorhinolaryngologists. Objectives of the study was to compare the results of FNAB and histopathological results in diagnosing malignancy and benign lesions of parotid gland and to determine the sensitivity, specificity and accuracy of FNAB.Methods: It is a retrospective clinical chart review study. In total, 61 patients (28 females and 33 males; average age, 46.31±15.79 years; age range: 12-82 years) with parotid gland masses who underwent preoperative FNAB were included in this study. All patients underwent FNAB under ultrasound guidance following clinical examination. Histopathological results of the surgical specimens and preoperative results of FNAB were compared and, the sensitivity, specify, positive predictive value (PPV), negative predictive value (NPV), the diagnostic accuracy of FNAB was calculated. A P-value <0.05 was considered to reflect statistical significance. Results: The specificity of FNAB was 100% and its sensitivity was 57.2%. Accuracy for benign lesion was 91.4%, accuracy for a malignancy was 42.8% and overall diagnostic accuracy was 92.0%, respectively. PPV for benign lesion was 91.4% and the NPV was 100%, respectively. PPV for malignancy was 100% and the NPV was 91.4%, respectively.Conclusions: We suggest that FNAB is a valid, safe, easy-to-use method for identifying of parotid gland neoplasms. We recommend FNAB for all potential surgical patients. In our opinion, good collaboration between the Otorhinolaryngologist and the pathologist provides the best results.

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Sialadenoma papilliferum of the parotid gland: Case report and review of literature

Cited by 12 publications

References 7 publications

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Sialadenoma Papilliferum: Analysis of Seven New Cases and Review of the Literature

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Diagnostic value of fine needle aspiration biopsy in parotid gland neoplasm

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