Sialic acid and food allergies: The link between nutrition and immunology

Liu, Guirong; Hao, Mengzhen; Zeng, Binghui; Liu, Manman; Wang, Junjuan; Sun, Shanfeng; Liu, Changqi; Che, Huilian

doi:10.1080/10408398.2022.2136620

Cited by 2 publications

(2 citation statements)

References 237 publications

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“…SA has shown great potential in the development of nutrition-based immunomodulatory therapies for food allergies, including antiallergic foods. Sialylated polysaccharides have anti-allergic effects, especially on food allergy [ 84 ]. Additionally, SA plays a pivotal role in fetal-maternal immune homeostasis during pregnancy.…”

Section: Biological Functions and Molecular Mechanisms Of Samentioning

confidence: 99%

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Li,

Lin,

Luo

et al. 2023

Foods

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Sialic acid (SA) is a kind of functional monosaccharide which exists widely in edible bird’s nest (EBN), milk, meat, mucous membrane surface, etc. SA is an important functional component in promoting brain development, anti-oxidation, anti-inflammation, anti-virus, anti-tumor and immune regulation. The intestinal mucosa covers the microbial community that has a significant impact on health. In the gut, SA can also regulate gut microbiota and metabolites, participating in different biological functions. The structure, source and physiological functions of SA were reviewed in this paper. The biological functions of SA through regulating key signaling pathways and target genes were discussed. In summary, SA can modulate gut microbiota and metabolites, which affect gene expressions and exert its biological activities. It is helpful to provide scientific reference for the further investigation of SA in the functional foods.

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Section: Biological Functions and Molecular Mechanisms Of Samentioning

confidence: 99%

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Li,

Lin,

Luo

et al. 2023

Foods

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“…3 Numerous health benefits of NeuAc have been demonstrated. It improves brain development and cognition; 4 possesses antiadhesive antibacterial and antiviral properties; 5,6 and displays immunomodulatory, 7 cardiovascular protection, 8 anticancer, 9 antioxidative, 10 and skin whitening activities. 11 It has been approved by the United States Food and Drug Administration (FDA) with notice no.…”

Section: ■ Introductionmentioning

confidence: 99%

Efficient Production of N-Acetylneuraminic Acid in Escherichia coli Based on the UDP-N-Acetylglucosamine Biosynthetic Pathway

Zhao

Zhu

Wang³

et al. 2023

J. Agric. Food Chem.

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N-Acetylneuraminic acid (NeuAc) is the predominant sialic acid found in human cells and a human-identical milk monosaccharide. Due to its numerous health benefits, it has great commercial potential in the pharmaceutical, cosmetic, and food industries. Microbial synthesis via metabolic engineering strategies is an important approach to its large-scale production. In this study, a NeuAc synthetic pathway was constructed in Escherichia coli BL21(DE3) by deleting the competitive pathway genes and introducing two genes encoding UDP-N-acetylglucosamine (GlcNAc) 2-epimerase (NeuC) and NeuAc synthase (NeuB). UDP-GlcNAc pathway genes, glmS, glmM, and glmU, were overexpressed to strengthen precursor supply for enhancement of NeuAc synthesis. The microbial source of neuC and neuB was optimized, and their expression was fine-tuned. In addition, glycerol as the carbon source showed a much better effect on NeuAc synthesis than glucose. The final engineered strain produced 7.02 g/L NeuAc by shake-flask cultivation. The titer was enhanced to 46.92 g/L by fed-batch cultivation, with the productivity of 0.82 g/L/h and 1.05 g/g DCW.

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Sialic acid and food allergies: The link between nutrition and immunology

Cited by 2 publications

References 237 publications

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Insights into the Structure, Metabolism, Biological Functions and Molecular Mechanisms of Sialic Acid: A Review

Efficient Production of N-Acetylneuraminic Acid in Escherichia coli Based on the UDP-N-Acetylglucosamine Biosynthetic Pathway

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